Výsledky vyhledávání - "Daniel Latour"

TBX2 driven switch from Androgen Receptor to Glucocorticoid Receptor signaling confers therapeutic resistance in Prostate Cancer

Autor: Sayanika Dutta, Girijesh Kumar Patel, Hamed Khedmatgozar, Daniel Latour, Manisha Tripathi, Srinivas Nandana

Recent studies have highlighted that androgen receptor (AR) signaling can be bypassed via activation of the glucocorticoid receptor (GR), and that this bypass drives enzalutamide resistance in advanced prostate cancer (PCa). However, the molecular me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f19b791eb10d94cd2c21f78c39833a29
https://doi.org/10.1101/2023.05.07.539754

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Abstract 1445: TBX2 acts as a molecular switch to downregulate androgen receptor and upregulate glucocorticoid receptor signaling in castrate resistant prostate cancer

Autor: Sayanika Dutta, Girijesh Patel, Hamed Khedmatgozar, Daniel Latour, Manisha Tripathi, Srinivas Nandana

Publikováno v: Cancer Research. 83:1445-1445

Background: A major obstacle in the treatment of metastatic castrate resistant prostate cancer (mCRPC) is acquired resistance to androgen deprivation therapy (ADT). It is now recognized that ADT, particularly the 2nd generation androgen receptor (AR)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b03e250ee25807998d23bfde3c97197b
https://doi.org/10.1158/1538-7445.am2023-1445

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