Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Daniel L. Rice"'
Autor:
Gustavo A Salazar, Aurelien Luciani, Xavier Watkins, Swaathi Kandasaamy, Daniel L Rice, Matthias Blum, Alex Bateman, Maria Martin
Motivation: The visualization of biological data is a fundamental technique that enables researchers to understand and explain biology. Some of these visualizations have become iconic, for instance: tree views for taxonomy, cartoon rendering of 3D pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b73367a86ac69a4938cecd6da1e8462b
https://doi.org/10.20944/preprints202305.1797.v1
https://doi.org/10.20944/preprints202305.1797.v1
Autor:
Gustavo A Salazar, Aurelien Luciani, Xavier Watkins, Swaathi Kandasaamy, Daniel L Rice, Matthias Blum, Alex Bateman, Maria Martin
Publikováno v:
Bioinformatics Advances.
Motivation The visualization of biological data is a fundamental technique that enables researchers to understand and explain biology. Some of these visualizations have become iconic, for instance: tree views for taxonomy, cartoon rendering of 3D pro
Autor:
Schuum P, Daniel B. Graham, Sun D, Seksik P, David T. Okou, Daniel L. Rice, David J. Cutler, Martti Färkkilä, Liefferinckx C, Segal Aw, Andrew T. Chan, Denis Franchimont, Beecham A, Subra Kugathasan, Stacey Gabriel, Stefan Schreiber, Baras A, Kirschner Bs, Goerg S, Juozas Kupcinskas, Jukka Koskela, John C. Mansfield, Kyle Gettler, Devoto M, Dobes A, Debby Laukens, Richard H. Duerr, Myriam Mni, Loescher B, Cosnes J, Mengesha E, William A. Faubion, Joshua Lewis, Graham A. Heap, Voskuil, Christine Stevens, Pekow J, Lisa W. Datta, Adam P. Levine, Khalili H, O’Charoen S, Dan Turner, Nikolas Pontikos, Natalie J. Prescott, Inga Peter, Marc P. Hoeppner, Chung D, Mark S. Silverberg, Dodge S, Talin Haritunians, Moayyedi P, Winter Hs, John D. Rioux, Andre Franke, Holm H. Uhlig, Ferreira M, Matthew Solomonson, Sokol H, Damas Om, Ramnik J. Xavier, Horowitz Je, Iyer, Eija Hämäläinen, Avila B, Dawany N, Newberry R, Bernstein C, Shawky R, Benjamin Glaser, Alison Simmons, Mamta Giri, Bruce E. Sands, Ann E. Pulver, Yuan K, Abreu Mt, Gil Atzmon, Allez M, Young J, Verstockt S, Aarno Palotie, Hongyan Huang, Kimmo Kontula, Ellinghaus E, van der Meulen Ae, Ahmad T, Oldenburg B, Cyriel Y. Ponsioen, Daly A, Dermot P.B. McGovern, Jeffrey C. Barrett, Peter M. Irving, Miles Parkes, Jacob L. McCauley, Päivi Saavalainen, Pierik Mj, Alain Bitton, Guhan Venkataraman, Rinse K. Weersma, Schiff Er, Manuel A. Rivas, Harry Ostrer, Bokemeyer B, Judy H. Cho, Sandra May, Michel Georges, Isabelle Cleynen, Moran Cj, Laudes M, Beaugerie L, Laura Fachal, Nir Barzilai, Mikko Hiltunen, Somineni H, Stephan R. Targan, Skeiceviciene J, Kelsen J, Sartor Br, Christopher A. Lamb, Philippe Goyette, Steven R. Brant, Souad Rahmouni, Mark J. Daly, Sheikh Sz, Edouard Louis, Jalas C, Carl A. Anderson, Severine Vermeire, Aleksejs Sazonovs
Genome-wide association studies (GWAS) have identified hundreds of loci associated with Crohns disease (CD), however, as with all complex diseases, deriving pathogenic mechanisms from these non-coding GWAS discoveries has been challenging. To complem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cb230603fc89c4e9c9583e329f9ebeb
https://doi.org/10.1101/2021.06.15.21258641
https://doi.org/10.1101/2021.06.15.21258641
Autor:
Timothy R. Orchard, Rosemary H Phillips, Stephen M. Evans, Arvind Ramadas, Paul R. Banim, Guy Chung-Faye, Subramaniam Ramakrishnan, Simon Panter, Leonie Grellier, Hasnain Jafferbhoy, Nigel Trudgill, Thankam Paul, Sian Kirkham, Anna J Pigott, M J Carter, Juan De La Revella Negro, Lisa Gervais, Zia Mazhar, Suranga Dharmisari, Richard A. Miller, Cathryn Preston, Alison Simmons, Rachel Cooney, Natalie C. Direkze, Deb Ghosh, Christian P. Selinger, Andrew A. Fagbemi, Rakesh Chaudhary, J R Fraser Cummings, Stephen Gore, James O. Lindsay, Tony C.K. Tham, David Hobday, Charles Murray, David Watts, Anne Willmott, Gill Watts, Sandip Sen, Mark Reppell, Amer Azaz, Shaji Sebastian, Neil Chanchlani, R B Johnston, Ben Hope, Salil Singh, Stephen Foley, Sunil Sonwalkar, Jonathon Snook, Lawrence Armstrong, Amanda Beale, Andy Li, Tariq Mahmood, Stephen Lewis, Kevin J. Monahan, Timothy J. McDonald, Gareth T. Jones, John N. Gordon, Nicholas A Kennedy, Sheldon C. Cooper, Gareth J. Walker, James W Hart, Sarah Langlands, Carl A. Anderson, Marcus Harbord, Alistair McNair, Achuth Shenoy, Graham A. Heap, Radhakrishnan Hariraj, Mandy H Perry, Charlie Lees, Shanika de Silva, Christopher J. Hawkey, Loukas Moutsianas, Matthew J Brookes, Christos Tzivinikos, Veena Zamvar, Cathryn Edwards, Claire Bell, Rebecca Saich, Peter M. Irving, Mark S. Smith, Phillip Mayhead, Christopher Macdonald, Dharamveer Basude, Andrew T. Cole, Ailsa Hart, Daniel R. Gaya, Kasamu Dawa Kabiru, Assad Butt, John C Mansfield, John Beckly, Anton V J Gunasekera, Simon Lal, Charles Pj Charlton, Astor Rodrigues, Craig Mowat, Joel Mawdsley, Palani Sathish Babu, John C. Mansfield, Mary-Anne Morris, Senthil V. Murugesan, Dermot P.B. McGovern, Richard Pollok, Franco Torrente, Jeffrey C. Barrett, Aleksejs Sazonovs, Aminda De Silva, George MacFaul, Paul Dunckley, Neeraj Prasad, Zahid Mahmood, Neil P. Shah, Richard Shenderey, Tariq Iqbal, Anjan Dhar, Bruce McLain, James R Goodhand, Anita Modi, Daniel L. Rice, Patrick Goggin, Alka Thakur, Vinod B. Patel, Vishal Kaushik, Scott Levison, Sonia Bouri, Fraser Cummings, Emma Wesley, Anurag Agrawal, Deven Vani, Jimmy K. Limdi, Miles Parkes, David A Elphick, Mark Tighe, Nicholas M. Croft, Charlie W. Lees, Helen Matthews, B K Baburajan, Andrew Bell, Melissa A. Smith, Tariq Ahmad, Stephen Bridger, Mark Tremelling, Matthew W. Johnson, John Fell, Claire Bewshea, Bim Bhaduri, Julie Doherty, Sean Weaver, Ben Colleypriest, Chuka U. Nwokolo, John de Caestecker, Richard K. Russell, Stuart Bloom
Publikováno v:
2020, ' HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease ', Gastroenterology, vol. 158, no. 1, pp. 189-199 . https://doi.org/10.1053/j.gastro.2019.09.041
BACKGROUND & AIMS: Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce the formation of anti-drug antibodies. The ability to identify pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24124ba5a4463940336ceef1408fceec
https://hdl.handle.net/20.500.11820/48abbae6-a739-4da4-9ca4-88c2ccd14323
https://hdl.handle.net/20.500.11820/48abbae6-a739-4da4-9ca4-88c2ccd14323
Autor:
Daniel L. Rice, Graham A. Heap, Tariq Ahmad, Gareth J. Walker, Miles Parkes, Charlie W. Lees, Carl A. Anderson, Dermot P.B. McGovern, John C. Mansfield, Nicholas A Kennedy, Jeffrey C. Barrett, Mandy H Perry, Timothy J. McDonald, James R Goodhand, Loukas Moutsianas, Aleksejs Sazonovs, Mark Reppell, Fraser Cummings, Claire Bewshea
SummaryBackgroundAnti-tumour necrosis factor (anti-TNF) therapies are the most widely used biologic therapies for treating immune-mediated diseases. Their efficacy is significantly reduced by the development of anti-drug antibodies which can lead to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fa0b90ae34998c993eebd5060946c5
Autor:
Jozef Gecz, Martin Kelemen, Nicholas G. Martin, Kerrie McAloney, Mari Niemi, Hilary C. Martin, Matthew E. Hurles, Sui Yu, Daniel L. Rice, Giuseppe Gallone, Scott Gordon, Jeffrey C. Barrett, Elizabeth J. Radford, Caroline F. Wright, Helen V. Firth, David R. FitzPatrick, Jeremy F. McRae
Publikováno v:
Niemi, M E K, Martin, H C, Rice, D L, Gallon, G, Gordon, S, Kelemen, M, McAloney, K, McRae, J, Radford, E J, Yu, S, Gecz, J, Martin, N G, Wright, C F, Fitzpatrick, D R, Firth, H, Hurles, M E & Barrett, J C 2018, ' Common genetic variants contribute to risk of rare severe neurodevelopmental disorders ', Nature, vol. 562, no. 7726, pp. 268-+ . https://doi.org/10.1038/s41586-018-0566-4
There are thousands of rare human disorders that are caused by single deleterious, protein-coding genetic variants(1). However, patients with the same genetic defect can have different clinical presentations(2-4), and some individuals who carry known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df417c889f9d2bf060ea2386742fe76d
https://doi.org/10.1101/309070
https://doi.org/10.1101/309070
Autor:
Natalie J. Prescott, Holm H. Uhlig, Alison Simmons, William G. Newman, Loukas Moutsianas, David C. Wilson, Sun-Gou Ji, John C. Mansfield, Christopher J. Hawkey, Graham A. Heap, Cathryn Edwards, Charlie W. Lees, Javier Gutierrez-Achury, James Lee, Nicholas A. Kennedy, Christopher A. Lamb, Jeffrey C. Barrett, Craig Mowat, Christopher G. Mathew, Jack Satsangi, Yang Luo, Daniel L. Rice, Carl A. Anderson, Paul Henderson, Ailsa Hart, Jeremy D. Sanderson, Tariq Ahmad, Elaine R. Nimmo, Mark Tremelling, Luke Jostins, Miles Parkes, Katrina M. de Lange
Publikováno v:
de Lange, K M, Moutsianas, L, James C. Lee, Lamb, C A, Luo, Y, Kennedy, N A, Jostins, L, Rice, D L, Gutierrez-Achury, J, Ji, S-G, Heap, G, Nimmo, E R, Edwards, C, Henderson, P, Mowat, C, Sanderson, J, Satsangi, J, Simmons, A, Wilson, D C, Tremelling, M, Hart, A, Mathew, C G, Newman, W, Parkes, M, Lees, C W, Uhlig, H, Hawkey, C, Prescott, N J, Ahmad, T, Mansfield, J C, Anderson, C A & Barrett, J C 2017, ' Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. ', Nature Genetics, vol. 49, pp. 256–261 . https://doi.org/10.1038/ng.3760
de Lange, K M, Moutsianas, L, Lee, J C, Lamb, C A, Luo, Y, Kennedy, N A, Jostins, L, Rice, D L, Gutierrez-Achury, J, Ji, S-G, Heap, G, Nimmo, E R, Edwards, C, Henderson, P, Mowatt, C, Sanderson, J, Satsangi, J, Simmons, A, Wilson, D C, Tremelling, M, Hart, A, Matthew, C G, Newman, W G, Parkes, M, Lees, C W, Uhlig, H, Hawkey, C, Prescott, N J, Ahmad, T, Mansfield, J C, Anderson, C A & Barrett, J C 2017, ' Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease ', Nature Genetics, vol. 49, no. 2, pp. 256–261 . https://doi.org/10.1038/ng.3760
Nature genetics
de Lange, K M, Moutsianas, L, Lee, J C, Lamb, C A, Luo, Y, Kennedy, N A, Jostins, L, Rice, D L, Gutierrez-Achury, J, Ji, S-G, Heap, G, Nimmo, E R, Edwards, C, Henderson, P, Mowat, C, Sanderson, J, Satsangi, J, Simmons, A, Wilson, D C, Tremelling, M, Hart, A, Mathew, C G, Newman, W G, Parkes, M, Lees, C W, Uhlig, H, Hawkey, C, Prescott, N J, Ahmad, T, Mansfield, J C, Anderson, C A & Barrett, J C 2017, ' Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease ', Nature Genetics, vol. 49, no. 2, pp. 256-261 . https://doi.org/10.1038/ng.3760
de Lange, K M, Moutsianas, L, Lee, J C, Lamb, C A, Luo, Y, Kennedy, N A, Jostins, L, Rice, D L, Gutierrez-Achury, J, Ji, S-G, Heap, G, Nimmo, E R, Edwards, C, Henderson, P, Mowatt, C, Sanderson, J, Satsangi, J, Simmons, A, Wilson, D C, Tremelling, M, Hart, A, Matthew, C G, Newman, W G, Parkes, M, Lees, C W, Uhlig, H, Hawkey, C, Prescott, N J, Ahmad, T, Mansfield, J C, Anderson, C A & Barrett, J C 2017, ' Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease ', Nature Genetics, vol. 49, no. 2, pp. 256–261 . https://doi.org/10.1038/ng.3760
Nature genetics
de Lange, K M, Moutsianas, L, Lee, J C, Lamb, C A, Luo, Y, Kennedy, N A, Jostins, L, Rice, D L, Gutierrez-Achury, J, Ji, S-G, Heap, G, Nimmo, E R, Edwards, C, Henderson, P, Mowat, C, Sanderson, J, Satsangi, J, Simmons, A, Wilson, D C, Tremelling, M, Hart, A, Mathew, C G, Newman, W G, Parkes, M, Lees, C W, Uhlig, H, Hawkey, C, Prescott, N J, Ahmad, T, Mansfield, J C, Anderson, C A & Barrett, J C 2017, ' Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease ', Nature Genetics, vol. 49, no. 2, pp. 256-261 . https://doi.org/10.1038/ng.3760
Genetic association studies have identified 215 risk loci for inflammatory bowel disease, thereby uncovering fundamental aspects of its molecular biology. We performed a genome-wide association study of 25,305 individuals and conducted a meta-analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9aa2a61e5e4729a3800e31b8cb129e0
https://doi.org/10.1038/ng.3760
https://doi.org/10.1038/ng.3760
Autor:
Richard H. Duerr, Dalin Li, Ming-Hsi Wang, Tariq Ahmad, John D. Rioux, Patrick Sulem, Daniel B. Graham, Steven R. Brant, Severine Vermeire, Mark Tremelling, James Lee, Leena Halme, K. de Lane, Miguel Regueiro, M Parkes, David C. Wilson, Alain Bitton, R. Milgrom, Daniel G. MacArthur, Marijn C. Visschedijk, Sören Mucha, Kenneth Croitoru, Alison Simmons, Mark S. Silverberg, Rinse K. Weersma, Jonas Halfvarson, Daniel L. Rice, J. M. Stempak, Christopher J. Hawkey, Mauro D'Amato, Christopher G. Mathew, Philippe Goyette, Frauke Degenhardt, Daniel F. Gudbjartsson, Mark J. Daly, Kari Stefansson, Beryl B. Cummings, Maarit Lappalainen, Päivi Saavalainen, Paulina Paavola-Sakki, P. Fleshner, Talin Haritunians, Joshua C. Randall, Elaine R. Nimmo, Taru Tukiainen, Christine Stevens, Subra Kugathasan, Monkol Lek, Andre Franke, Kimmo Kontula, Unnur Thorsteinsdottir, Andrew Hart, Martin O. Pollard, Gabrielle Boucher, Natalie J. Prescott, Benjamin M. Neale, Holm H. Uhlig, Carl A. Anderson, Ashwin N. Ananthakrishnan, Luke Jostins, C. Mowatt, Judy H. Cho, B. Newman, A. Nicole Desch, Yang Luo, Dermot P.B. McGovern, Clara Abraham, Ingileif Jonsdottir, Jeffrey C. Barrett, John C. Mansfield, Jean-Paul Achkar, Charlie W. Lees, Martti Färkkilä, Ramnik J. Xavier, S. R. Targan, Manuel A. Rivas, Deborah D. Proctor, Johan Van Limbergen, Nicholas A. Kennedy, Christopher A. Lamb, Jürgen Glas, Vito Annese, Yashoda Sharma, Phil Schumm, Graham A. Heap, Cathryn Edwards, Lotta L. E. Koskinen, Jack Satsangi, Mitja I. Kurki, Aarno Palotie
Publikováno v:
Rivas, M A, Graham, D, Sulem, P, Stevens, C, Desch, A N, Goyette, P, Gudbjartsson, D, Jonsdottir, I, Thorsteinsdottir, U, Degenhardt, F, Mucha, S, Kurki, M I, Li, D, D'Amato, M, Annese, V, Vermeire, S, Weersma, R K, Halfvarson, J, Paavola-Sakki, P, Lappalainen, M, Lek, M, Cummings, B, Tukiainen, T, Haritunians, T, Halme, L, Koskinen, L L E, Ananthakrishnan, A N, Luo, Y, Heap, G A, Visschedijk, M C, MacArthur, D G, Neale, B M, Ahmad, T, Anderson, C A, Brant, S R, Duerr, R H, Silverberg, M S, Cho, J H, Palotie, A, Saavalainen, P, Kontula, K, Färkkilä, M, McGovern, D P B, Franke, A, Stefansson, K, Rioux, J D, Xavier, R J, Daly, M J, Barrett, J, De Lane, K, Edwards, C, Hart, A, Hawkey, C, Jostins, L, Kennedy, N, Lamb, C, Lee, J, Lees, C, Mansfield, J, Mathew, C, Mowatt, C, Newman, B, Nimmo, E, Parkes, M, Pollard, M, Prescott, N, Randall, J, Rice, D, Satsangi, J, Simmons, A, Tremelling, M, Uhlig, H, Wilson, D, Abraham, C, Achkar, J P, Bitton, A, Boucher, G, Croitoru, K, Fleshner, P, Glas, J, Kugathasan, S, Limbergen, J V, Milgrom, R, Proctor, D, Regueiro, M, Schumm, P L, Sharma, Y, Stempak, J M, Targan, S R & Wang, M H 2016, ' A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis ', Nature Communications, vol. 7, 12342 . https://doi.org/10.1038/ncomms12342
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Rivas, M A, Graham, D, Sulem, P, Stevens, C, Desch, A N, Goyette, P, Gudbjartsson, D, Jonsdottir, I, Thorsteinsdottir, U, Degenhardt, F, Mucha, S, Kurki, M I, Li, D, D'Amato, M, Annese, V, Vermeire, S, Weersma, R K, Halfvarson, J, Paavola-Sakki, P, Lappalainen, M, Lek, M, Cummings, B, Tukiainen, T, Haritunians, T, Halme, L, Koskinen, L L E, Ananthakrishnan, A N, Luo, Y, Heap, G A, Visschedijk, M C, MacArthur, D G, Ahmad, T, Anderson, C A, Brant, S R, Duerr, R H, Silverberg, M S, Cho, J H, Palotie, A, Saavalainen, P, Kontula, K, Färkkilä, M, McGovern, D P B, Franke, A, Stefansson, K, Rioux, J D, Xavier, R J, Daly, M J, Hawkey, C, Mathew, C, Prescott, N 2016, ' A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis ', Nature Communications, vol. 7, 12342 . https://doi.org/10.1038/ncomms12342
UK IBD Genetics Consortium & Newman, W 2016, ' A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis ', Nature Communications, vol. 7, 12342 . https://doi.org/10.1038/ncomms12342
Nature Communications, 7:12342. Nature Publishing Group
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Rivas, M A, Graham, D, Sulem, P, Stevens, C, Desch, A N, Goyette, P, Gudbjartsson, D, Jonsdottir, I, Thorsteinsdottir, U, Degenhardt, F, Mucha, S, Kurki, M I, Li, D, D'Amato, M, Annese, V, Vermeire, S, Weersma, R K, Halfvarson, J, Paavola-Sakki, P, Lappalainen, M, Lek, M, Cummings, B, Tukiainen, T, Haritunians, T, Halme, L, Koskinen, L L E, Ananthakrishnan, A N, Luo, Y, Heap, G A, Visschedijk, M C, MacArthur, D G, Ahmad, T, Anderson, C A, Brant, S R, Duerr, R H, Silverberg, M S, Cho, J H, Palotie, A, Saavalainen, P, Kontula, K, Färkkilä, M, McGovern, D P B, Franke, A, Stefansson, K, Rioux, J D, Xavier, R J, Daly, M J, Hawkey, C, Mathew, C, Prescott, N 2016, ' A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis ', Nature Communications, vol. 7, 12342 . https://doi.org/10.1038/ncomms12342
UK IBD Genetics Consortium & Newman, W 2016, ' A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis ', Nature Communications, vol. 7, 12342 . https://doi.org/10.1038/ncomms12342
Nature Communications, 7:12342. Nature Publishing Group
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. Protein-truncating variants protective agains
Autor:
Graham A. Heap, James Lee, Nicholas A. Kennedy, Cathryn Edwards, Ailsa Hart, Daniel L. Rice, Javier Gutierrez-Achury, Christopher J. Hawkey, Jeremy D. Sanderson, Luke Jostins, Miles Parkes, Katrina M. de Lange, Mark Tremelling, David C. Wilson, Jeffrey C. Barrett, Carl A. Anderson, William G. Newman, Sun-Gou Ji, Elaine R. Nimmo, Paul Henderson, Natalie J. Prescott, Jack Satsangi, Christopher G. Mathew, Loukas Moutsianas, Yang Luo, Charlie W. Lees, Alison Simmons, Tariq Ahmad, Holm H. Uhlig, John C. Mansfield, Craig Mowat, Christopher A. Lamb
Genetic association studies have identified 210 risk loci for inflammatory bowel disease1–7, which have revealed fundamental aspects of the molecular biology of the disease, including the roles of autophagy and Th17 cell signaling and development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700dc483893cae56ee720e56c1510179
https://doi.org/10.1101/058255
https://doi.org/10.1101/058255