Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Daniel L. Karl"'
Autor:
Steven W. Criscione, Matthew J. Martin, Derek B. Oien, Aparna Gorthi, Ricardo J. Miragaia, Jingwen Zhang, Huawei Chen, Daniel L. Karl, Kerrin Mendler, Aleksandra Markovets, Sladjana Gagrica, Oona Delpuech, Jonathan R. Dry, Michael Grondine, Maureen M. Hattersley, Jelena Urosevic, Nicolas Floc’h, Lisa Drew, Yi Yao, Paul D. Smith
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-13 (2022)
Abstract Third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs), including osimertinib, an irreversible EGFR-TKI, are important treatments for non-small cell lung cancer with EGFR-TKI sensitizing or EGFR T790M resistance mutations. While patien
Externí odkaz:
https://doaj.org/article/d7852854a3ba43459578c3fb424140e2
Autor:
Na Man, Gloria Mas, Daniel L. Karl, Jun Sun, Fan Liu, Qin Yang, Miguel Torres-Martin, Hidehiro Itonaga, Concepcion Martinez, Shi Chen, Ye Xu, Stephanie Duffort, Pierre-Jacques Hamard, Chuan Chen, Beth E. Zucconi, Luisa Cimmino, Feng-Chun Yang, Mingjiang Xu, Philip A. Cole, Maria E. Figueroa, Stephen D. Nimer
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
Myelodysplastic syndromes (MDS) are hematopoietic stem and progenitor cell (HSPC) malignancies characterized by ineffective hematopoiesis and an increased risk of leukemia transformation. Epigenetic regulators are recurrently mutated in MDS, directly
Externí odkaz:
https://doaj.org/article/da3ffac6658646129e6aad70db2c0b9e
Autor:
Pierre-Jacques Hamard, Gabriel E. Santiago, Fan Liu, Daniel L. Karl, Concepcion Martinez, Na Man, Adnan K. Mookhtiar, Stephanie Duffort, Sarah Greenblatt, Ramiro E. Verdun, Stephen D. Nimer
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2643-2657 (2018)
Summary: Protein arginine methyltransferase 5 (PRMT5) is overexpressed in many cancer types and is a promising therapeutic target for several of them, including leukemia and lymphoma. However, we and others have reported that PRMT5 is essential for n
Externí odkaz:
https://doaj.org/article/3f53d8256d1a4982a660f6bf4d6b6001
Autor:
Gloria Mas, Na Man, Yuichiro Nakata, Concepcion Martinez-Caja, Daniel L. Karl, Felipe Beckedorff, Francesco Tamiro, Chuan Chen, Stephanie Duffort, Hidehiro Itonaga, Adnan K. Mookhtiar, Kranthi Kunkalla, Alfredo M. Valencia, Clayton K. Collings, Cigall Kadoch, Francisco Vega, Scott C. Kogan, Lluis Morey, Daniel Bilbao, Stephen D. Nimer
Publikováno v:
Journal of Clinical Investigation.
Autor:
Sam S. Yoon, Patricia A. D'Amore, Sandra Ryeom, Courtney Rothrock, Ugwuji N. Maduekwe, Daniel L. Karl, Yoon-Jin Lee
Supplementary Figures 1-6 from Differential Effects of VEGFR-1 and VEGFR-2 Inhibition on Tumor Metastases Based on Host Organ Environment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144dff14f152ffe6d81a2562465e9453
https://doi.org/10.1158/0008-5472.22385580.v1
https://doi.org/10.1158/0008-5472.22385580.v1
Autor:
Sam S. Yoon, Patricia A. D'Amore, Sandra Ryeom, Courtney Rothrock, Ugwuji N. Maduekwe, Daniel L. Karl, Yoon-Jin Lee
Supplementary Figure Legends 1-6 from Differential Effects of VEGFR-1 and VEGFR-2 Inhibition on Tumor Metastases Based on Host Organ Environment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82da19ed4c22136fb619fc183c73b2d1
https://doi.org/10.1158/0008-5472.22385583.v1
https://doi.org/10.1158/0008-5472.22385583.v1
Autor:
Stephen D. Nimer, Adnan K. Mookhtiar, Fan Liu, Concepción Martínez, Ye Xu, Izidore S. Lossos, Pierre-Jacques Hamard, Xiaoqing Lu, Na Man, Daniel L. Karl, Jun Sun
Publikováno v:
Nucleic Acids Research
Protein arginine methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of arginine residues in histones H3 and H4, marks that are generally associated with transcriptional repression. However, we found that PRMT5 inhibition or depletion
Autor:
Feng Chun Yang, Philip A. Cole, Qin Yang, Chuan Chen, Beth E. Zucconi, Fan Liu, Stephen D. Nimer, Concepción Martínez, Shi Chen, Stephanie Duffort, Ye Xu, Pierre-Jacques Hamard, Luisa Cimmino, Na Man, Jun Sun, Daniel L. Karl, Maria E. Figueroa, Miguel Torres-Martin, Hidehiro Itonaga, Gloria Mas, Mingjiang Xu
Publikováno v:
JCI Insight
Myelodysplastic syndromes (MDS) are hematopoietic stem and progenitor cell (HSPC) malignancies characterized by ineffective hematopoiesis and an increased risk of leukemia transformation. Epigenetic regulators are recurrently mutated in MDS, directly
Autor:
Stephanie Duffort, Stephen D. Nimer, Ramiro E. Verdun, Adnan K. Mookhtiar, Fan Liu, Concepción Martínez, Sarah Greenblatt, Gabriel E. Santiago, Pierre-Jacques Hamard, Na Man, Daniel L. Karl
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2643-2657 (2018)
Summary: Protein arginine methyltransferase 5 (PRMT5) is overexpressed in many cancer types and is a promising therapeutic target for several of them, including leukemia and lymphoma. However, we and others have reported that PRMT5 is essential for n
Autor:
Sergey Naumenko, Andrew Bloecher, Andrew A. Mortlock, Kathleen A. Burke, Pablo E. Cingolani, Veerendra Munugalavadla, Jennifer R. Brown, Maurizio Scaltriti, Megan Callahan, John C. Byrd, Elena Bibikova, Barrett Nuttall, Brian Dougherty, Daniel L. Karl, J. Carl Barrett, Kerrin Mendler, Richard R. Furman, James Hadfield, Steven Criscione
Publikováno v:
Blood. 138:4361-4361
Background: Bruton's tyrosine kinase (BTK) inhibition is a key component in B-cell receptor signaling and is one of the most prominent therapeutic targets in hematologic malignancies. Acalabrutinib is a highly selective, covalent, potent next-generat