Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Daniel L. Jasinski"'
Autor:
Aaron E. Foster, J. Henri Bayle, Xiaomei Wang, Jan L. Medina, Daniel L. Jasinski, David M. Spencer
Publikováno v:
Blood Adv
Natural killer (NK) cells expressing chimeric antigen receptors (CARs) are a promising anticancer immunotherapy, leveraging both innate NK cell antitumor activity and target-specific cytotoxicity. Inducible MyD88/CD40 (iMC) is a potent, rimiducid-reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bad121de5ce3516833aefe12d8f768
https://doi.org/10.1182/bloodadvances.2020001510
https://doi.org/10.1182/bloodadvances.2020001510
Publikováno v:
ACS Nano. 13:4603-4612
From the original sequencing of the human genome, it was found that about 98.5% of the genome did not code for proteins. Subsequent studies have now revealed that a much larger portion of the genome is related to short or long noncoding RNAs that reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0ab4c9cb8810e12fc3d49b2fee92e5
https://doi.org/10.1021/acsnano.9b00649
https://doi.org/10.1021/acsnano.9b00649
Publikováno v:
Cancer Letters. 414:57-70
The past decades have witnessed the successful transition of several nanotechnology platforms into the clinical trials. However, specific delivery of therapeutics to tumors is hindered by several barriers including cancer recognition and tissue penet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a066e9a9d993e545489b63996d63f27f
https://doi.org/10.1016/j.canlet.2017.09.043
https://doi.org/10.1016/j.canlet.2017.09.043
Publikováno v:
Human Gene Therapy. 29:77-86
Liver or other organ accumulation of drugs is one of the major problems that leads to toxicity and side effects in therapy using chemicals or other macromolecules. It has been shown that specially designed RNA nanoparticles can specifically target ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6634120a654350caad0f3f685814f594
https://doi.org/10.1089/hum.2017.054
https://doi.org/10.1089/hum.2017.054
Autor:
Daniel L. Jasinski, Chia-Yang Liu, Peixuan Guo, S. Kevin Li, Ponwanit Charoenputtakun, Zhanquan Shi
Publikováno v:
Journal of Controlled Release. 270:14-22
Thermodynamically and chemically stable RNA nanoparticles derived from the three-way junction (3WJ) of the pRNA from bacteriophage phi29 DNA packaging motor were examined previously for ocular delivery. It was reported that, after subconjunctival inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c031fae22941296c1e02fbca77d7f90
https://doi.org/10.1016/j.jconrel.2017.11.028
https://doi.org/10.1016/j.jconrel.2017.11.028
Publikováno v:
Advanced Materials. 28:10079-10087
Constructing containers with defined shape and size to load and protect therapeutics such as native RNA, DNA, or peptides, for controlled release in the human body has long been a dream. Here we report the fabrication of 3D RNA prisms for loading and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55457c80aa27eb03728671f39f28555c
https://doi.org/10.1002/adma.201603180
https://doi.org/10.1002/adma.201603180
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 26(3)
Drugs with ideal pharmacokinetic profile require long half-life but little organ accumulation. Generally, PK and organ accumulation are contradictory factors: smaller size leads to faster excretion and shorter half-lives and thus a lower tendency to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fee201505430bb1748cfe7f36f20df3
https://pubmed.ncbi.nlm.nih.gov/29402549
https://pubmed.ncbi.nlm.nih.gov/29402549
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1632
RNA is rapidly emerging as a versatile building block for nanoparticle assembly due to its simplicity in base pairing, while exhibiting diversity in function such as enzymatic activity similar to some proteins. Recent advances in RNA nanotechnology h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::398c36102747c51f09dbdd867264f765
https://pubmed.ncbi.nlm.nih.gov/28730451
https://pubmed.ncbi.nlm.nih.gov/28730451
Autor:
Kheiria, Benkato, Benjamin, O'Brien, My N, Bui, Daniel L, Jasinski, Peixuan, Guo, Emil F, Khisamutdinov
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1632
Temperature gradient gel electrophoresis (TGGE) is a powerful tool used to analyze the thermal stabilities of nucleic acids. While TGGE is a decades-old technique, it has recently gained favor in the field of RNA nanotechnology, notably in assessing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::283ff1afec6a0c87b4aba2d7adb82aa4
https://pubmed.ncbi.nlm.nih.gov/28730436
https://pubmed.ncbi.nlm.nih.gov/28730436
Publikováno v:
ACS Nano
The field of RNA nanotechnology has advanced rapidly during the past decade. A variety of programmable RNA nanoparticles with defined shape, size, and stoichiometry have been developed for diverse applications in nanobiotechnology. The rising popular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c82d66ce7bdee0efaac434b7957637a
https://pubmed.ncbi.nlm.nih.gov/28045501
https://pubmed.ncbi.nlm.nih.gov/28045501