Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Daniel L. Comins"'
Autor:
Daniel L. Comins
Publikováno v:
Molecules, Vol 27, Iss 6, p 1833 (2022)
A short and economical synthesis of various 2-methylaminopyidine amides (MAPA) from 2-bromopyridine has been developed using the catalytic Goldberg reaction. The effective catalyst was formed in situ by the reaction of CuI and 1,10-phenanthroline in
Externí odkaz:
https://doaj.org/article/f0902edabf514695a538b20157866b65
Autor:
Daniel L. Comins, Kazuhiro Higuchi
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 3, Iss 1, p 42 (2007)
A general synthesis of various benzo-fused indolizidine alkaloid mimics has been developed. The indolizidine derivatives 8 were prepared via heteroaryl Grignard addition to N-acylpyridinium salts followed by an intramolecular Heck cyclization. Furthe
Externí odkaz:
https://doaj.org/article/a51b729edadc43499baf0012d9ae2f99
Autor:
Ibrahim D. Bori, Daniel L. Comins
Publikováno v:
Arkivoc. 2021:57-72
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e0002309eebf4781412a234695bcbcd
https://doi.org/10.24820/ark.5550190.p011.464
https://doi.org/10.24820/ark.5550190.p011.464
Publikováno v:
The Journal of Organic Chemistry. 81:11529-11534
The syntheses of seven novel amido nicotine derivatives 12-18 from (S)-nicotine are presented. (S)-Nicotine and (S)-6-chloronicotine derivatives were cross-coupled with the corresponding amides 6-10 at the C-4 position of the pyridine ring via copper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3bbaecacb2342a87c0ec9939b1f6c51
https://doi.org/10.1021/acs.joc.6b02319
https://doi.org/10.1021/acs.joc.6b02319
Autor:
Anne-Cécile Hiebel, Daniel L. Comins
Publikováno v:
Tetrahedron. 71:7354-7360
A dihydropyridone-mediated approach to the morphine skeleton was investigated. The hexahydroisoquinoline 2 was synthesized in nine steps using N-acylpyridinium chemistry and dihydropyridone functionalization methods. This new approach should be usefu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d67671a711a2e2da97f02caeddc9ae81
https://doi.org/10.1016/j.tet.2015.04.086
https://doi.org/10.1016/j.tet.2015.04.086
Publikováno v:
The Journal of organic chemistry, vol 79, iss 23
The Journal of Organic Chemistry
The Journal of Organic Chemistry
The role of twist-boat conformers of cyclohexanones in hydride reductions was explored. The hydride reductions of a cis-2,6-disubstituted N-acylpiperidone, an N-acyltropinone, and tert-butylcyclohexanone by lithium aluminum hydride and by a bulky bor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1c5cd6086a8deb6bd71ef8846a8eb8
https://doi.org/10.1021/jo5022635
https://doi.org/10.1021/jo5022635
Autor:
Daniel L. Comins, Sergey V. Tsukanov
Publikováno v:
The Journal of Organic Chemistry
Concise and highly stereocontrolled total syntheses of racemic and enantiopure frog alkaloid 205B (1) were accomplished in 11 steps from 4-methoxypyridines 6 and 7 in overall yields of 8 and 8%, respectively. The assembly of the core of the natural p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ecbccc98990b5f51c05e4d01ec50ce
https://doi.org/10.1021/jo501415r
https://doi.org/10.1021/jo501415r
Publikováno v:
The Journal of Organic Chemistry
A strategy for the synthesis of the lycopodium alkaloid dihydrolycolucine (1) has been investigated. Synthetic routes were developed based on N-acylpyridinium salt chemistry to prepare target fragments 3 and 4 that could ultimately converge to the na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b8fdb74d96e77aef0885be94a250ae
http://europepmc.org/articles/PMC4066915
http://europepmc.org/articles/PMC4066915
Publikováno v:
Tetrahedron Letters. 56:3683-3685
A racemic and asymmetric synthesis of cermizine D (1) was accomplished in six steps from 4-methoxypyridine or 4-methoxy-3-TIPS-pyridine in 12% and 13% overall yield, respectively. A key step is a stereoselective 1,4-addition of a 2-((trimethylsilyl)m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccf509e5fa07c51c777386f0807c37bd
https://doi.org/10.1016/j.tetlet.2015.04.013
https://doi.org/10.1016/j.tetlet.2015.04.013
Publikováno v:
The Journal of organic chemistry. 81(21)
Herein is described an original approach to access a tricyclic framework of the lepadiformine-type alkaloids. A Grignard/N-acylpyridinium salt reaction of a 4-methoxytetrahydroquinoline is the key carbon–carbon bond-forming step that was used to es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d009dbe34c3bc4d13a626d22cd206f3
https://pubmed.ncbi.nlm.nih.gov/27626463
https://pubmed.ncbi.nlm.nih.gov/27626463