Výsledky vyhledávání - "Daniel L. Cherry"

Data from CHK1 Inhibition Is Synthetically Lethal with Loss of B-Family DNA Polymerase Function in Human Lung and Colorectal Cancer Cells

Autor: Paul Workman, Michelle D. Garrett, Paul A. Clarke, Ian Collins, Daniel L. Cherry, Michael I. Walton, Rebecca F. Rogers

Checkpoint kinase 1 (CHK1) is a key mediator of the DNA damage response that regulates cell-cycle progression, DNA damage repair, and DNA replication. Small-molecule CHK1 inhibitors sensitize cancer cells to genotoxic agents and have shown single-age

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4dcea0f52b51238a6de6ffd30f91afbf
https://doi.org/10.1158/0008-5472.c.6511765.v1

Zobrazit plný text záznamu

Supplementary Figures 1-12 from CHK1 Inhibition Is Synthetically Lethal with Loss of B-Family DNA Polymerase Function in Human Lung and Colorectal Cancer Cells

Autor: Paul Workman, Michelle D. Garrett, Paul A. Clarke, Ian Collins, Daniel L. Cherry, Michael I. Walton, Rebecca F. Rogers

Supplementary Figures - SF1: GI50 determinations for CHK1 inhibitor SRA737 in A549 and SW620 cells. SF2: Knockdown of POLA1, POLE or POLE2 sensitises A549 and SW620 cells to the CHK1 inhibitor MK-8776. SF3: Knockdown of CHK1 sensitises A549 cells to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d79c50e198ed327844b70f5cfb38389
https://doi.org/10.1158/0008-5472.22424413.v1

Zobrazit plný text záznamu

Supplementary Tables 1-5 from CHK1 Inhibition Is Synthetically Lethal with Loss of B-Family DNA Polymerase Function in Human Lung and Colorectal Cancer Cells

Autor: Paul Workman, Michelle D. Garrett, Paul A. Clarke, Ian Collins, Daniel L. Cherry, Michael I. Walton, Rebecca F. Rogers

Supplementary Tables - ST1: Significant siRNA hits identified from the large-scale synthetic lethal siRNA screen combined with SRA737 in A549 cells. ST2: Significant siRNA hits identified from the large-scale synthetic lethal siRNA screen combined wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a04c1b488ade94296676f4e30acfbc1
https://doi.org/10.1158/0008-5472.22424410.v1

Zobrazit plný text záznamu

CHK1 inhibition is synthetically lethal with loss of B-family DNA polymerase function in human lung and colorectal cancer cells

Autor: Paul Workman, Ian Collins, Rebecca Rogers, Daniel L. Cherry, Michelle D. Garrett, Paul A. Clarke, Michael I. Walton

Publikováno v: Cancer Res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01742821eafbec244354ea0af46d7959

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání