Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Daniel L. Abravanel"'
Autor:
Jorge Gómez Tejeda Zañudo, Romualdo Barroso-Sousa, Esha Jain, Qingchun Jin, Tianyu Li, Jorge E. Buendia-Buendia, Alyssa Pereslete, Daniel L. Abravanel, Arlindo R. Ferreira, Eileen Wrabel, Karla Helvie, Melissa E. Hughes, Ann H. Partridge, Beth Overmoyer, Nancy U. Lin, Nabihah Tayob, Sara M. Tolaney, Nikhil Wagle
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The landscape of cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) resistance is still being elucidated and the optimal subsequent therapy to overcome resistance remains uncertain. Here we present the final results of a phase Ib/IIa, open-labe
Externí odkaz:
https://doaj.org/article/fbf0b09b34034b3ca24835f1877b47b7
Autor:
Jorge Gómez Tejeda Zañudo, Romualdo Barroso-Sousa, Esha Jain, Qingchun Jin, Tianyu Li, Jorge E. Buendia-Buendia, Alyssa Pereslete, Daniel L. Abravanel, Arlindo R. Ferreira, Eileen Wrabel, Karla Helvie, Melissa E. Hughes, Ann H. Partridge, Beth Overmoyer, Nancy U. Lin, Nabihah Tayob, Sara M. Tolaney, Nikhil Wagle
Even though multiple resistance mechanisms and pathways for cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) have been discovered, the complete landscape of resistance is still being elucidated. Moreover, the optimal subsequent therapy to overcome re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::872c3b9e448db023cc089db73482a5cb
https://doi.org/10.1101/2022.07.11.22277416
https://doi.org/10.1101/2022.07.11.22277416
Autor:
Eswar Prasad Ramachandran Iyer, Adam H. Marblestone, Chih-Chieh Yu, Aviv Regev, Nikhil Wagle, Nicole Cullen, Atsushi Kajita, Nikita Pak, Johanna Klughammer, Sukanya Punthambaker, Andrew C. Payne, Anubhav Sinha, Bruce E. Johnson, Ho-Jun Suk, Fei Chen, Andrew G Xue, Yi Cui, Orit Rozenblatt-Rosen, Ru Wang, Jeremy A. Miller, Daniel L Abravanel, Ana Lako, Karla Helvie, Yosuke Bando, Michal Slyper, Paul Reginato, Paul W. Tillberg, Chun-Chen Yao, Ed S. Lein, Shahar Alon, Judit Jané-Valbuena, Asmamaw T Wassie, Daniel Goodwin, Evan R. Daugharthy, Richie E. Kohman, Edward S. Boyden, George M. Church, Songlei Liu, Karl Marrett, Robert Prior, Julia Waldman, Scott J. Rodig
Methods for highly multiplexed RNA imaging are limited in spatial resolution, and thus in their ability to localize transcripts to nanoscale and subcellular compartments. We adapt expansion microscopy, which physically expands biological specimens, f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd7f985d5dd30287e6f6e3f0aa6afed8
https://doi.org/10.1101/2020.05.13.094268
https://doi.org/10.1101/2020.05.13.094268
Autor:
Daniel L Abravanel, Johanna Klughammer, Timothy Blosser, Yury Goltsev, Sizun Jiang, Yunjao Bai, Evan Murray, Shahar Alon, Yi Cui, Daniel R Goodwin, Anubhav Sinha, Ofir Cohen, Michal Slyper, Orr Ashenberg, Danielle Dionne, Judit Jané-Valbuena, Caroline BM Porter, Asa Segerstolpe, Julia Waldman, Sébastien Vigneau, Karla Helvie, Allison Frangieh, Laura DelloStritto, Miraj Patel, Jingyi We, Kathleen Pfaff, Nicole Cullen, Ana Lako, Madison Turner, Isaac Wakiro, Sara Napolitano, Abhay Kanodia, Rebecca Ortiz, Colin MacKichan, Stephanie Inga, Judy Chen, Aaron R Thorner, Asaf Rotem, Scott Rodig, Fei Chen, Edward S Boyden, Garry P Nolan, Xiaowei Zhuang, Orit Rozenblatt-Rosen, Bruce E Johnson, Aviv Regev, Nikhil Wagle
Publikováno v:
Cancer Research. 82:PD6-03
Metastatic breast cancer (MBC) remains incurable due to inevitable development of therapeutic resistance. Although tumor cell intrinsic mechanisms of resistance in MBC are beginning to be elucidated by bulk sequencing studies, the roles of the tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74bea1c3ab5b2c003c8f6cfa59ff103f
https://doi.org/10.1158/1538-7445.sabcs21-pd6-03
https://doi.org/10.1158/1538-7445.sabcs21-pd6-03
Autor:
Jorge Gomez Tejeda Zanudo, Romualdo Barroso-Sousa, Esha Jain, Jorge Buendia-Buendia, Tianyu Li, Nabihah Tayob, Rebecca Rees, Alyssa Pereslete, Arlindo R. Ferreira, Daniel L. Abravanel, Karla Helvie, Ann H. Partridge, Beth Overmoyer, Eric P. Winer, Nikhil Wagle, Sara M. Tolaney
Publikováno v:
Cancer Research. 82:P4-01
Background: Multiple studies in HR+/HER2- MBC have identified a variety of genomic resistance mechanisms to CDK4/6 inhibitors, but the complete landscape of resistance mechanisms is still being elucidated. A clinical trial evaluating the benefit of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beae2ef26c3b754342e87954ac77000a
https://doi.org/10.1158/1538-7445.sabcs21-p4-01-06
https://doi.org/10.1158/1538-7445.sabcs21-p4-01-06
Autor:
Esha Jain, Dewey Kim, Jorge Gomez Tejeda Zanudo, Sara Balch, Mary McGillicuddy, Brett N. Tomson, Tania G. Hernandez, Beena S. Thomas, Daniel L. Abravanel, Shahrayz Shah, Rafael Ramos, Delia Sosa, Ilan Small, Lauren Sterlin, Sarah Winnicki, Colleen Nguyen, Micheal Dunphy, Elana Anastasio, Todd R. Golub, Corrie A. Painter, Nikhil Wagle
Publikováno v:
Cancer Research. 82:PD6-02
Background: The Metastatic Breast Cancer Project (MBCproject) is an ongoing research study that directly engages patients (pts) through social media and advocacy groups, and empowers them to share their biospecimens, clinical history, and experiences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60ccc9137c61992760fff65a1cea7a6a
https://doi.org/10.1158/1538-7445.sabcs21-pd6-02
https://doi.org/10.1158/1538-7445.sabcs21-pd6-02
Publikováno v:
Journal of Thoracic Oncology. 13:e131-e133
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cba557c6f05922704f13db19d5fc19d
https://doi.org/10.1016/j.jtho.2018.03.026
https://doi.org/10.1016/j.jtho.2018.03.026
Autor:
Danielle Dionne, Mike Cuoco, Matan Hofree, Nan Lin, Johanna Klughammer, Ofir Cohen, Laura DelloStritto, Orit Rozenblatt-Rosen, Judit Jané-Valbuena, Jingyi Wu, Julia Waldman, Eric P. Winer, Christopher Rodman, Asaf Rotem, Karla Helvie, Lan Nguyen, Orr Ashenberg, Aviv Regev, Angie Mayorga, Bruce E. Johnson, Michal Slyper, Daniel L Abravanel, Allison Frangieh, Sébastien Vigneau, Nikhil Wagle
Publikováno v:
Cancer Research. 80:GS6-05
While recent studies have begun to elucidate the genomics of metastatic breast cancer (MBC), the transcriptional programs (progs) that drive the drug-resistant phenotype remain poorly understood. We prospectively collected biopsies from patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f1a5351e3f93bfab02e6a0d507fa999
https://doi.org/10.1158/1538-7445.sabcs19-gs6-05
https://doi.org/10.1158/1538-7445.sabcs19-gs6-05
Autor:
Nancy U Nancy U. Lin, Samuel S. Freeman, Aviv Regev, Jorge E Buendia-Bue, EP Winer, Victor Adalsteinsson, Christian Kapstad, Pingping Mao, Seth A. Wander, Ofir Cohen, Esha Jain, Dewey Kim, Kailey J. Kowalski, Nikhil Wagle, Karla Helvie, Utthara Nayar, Gad Getz, Adrienne G. Waks, Daniel L Abravanel
Publikováno v:
Cancer Research. 80:GS2-02
While recent studies have begun characterizing the metastatic breast cancer (MBC) genomics, our understanding of mechanisms of acquired endocrine-resistance, their induced cell-state, and their altered drug-response profile, remains lacking. We colle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bda23ed9c56f29b957a9e6f4b8dbfdf
https://doi.org/10.1158/1538-7445.sabcs19-gs2-02
https://doi.org/10.1158/1538-7445.sabcs19-gs2-02
Autor:
Christopher J. Sterner, Dhruv K. Pant, Daniel L. Abravanel, Meredith A. Collins, Tien-chi Pan, George K. Belka, Lewis A. Chodosh
Breast cancer mortality is principally due to recurrent tumors that arise from a reservoir of residual tumor cells that survive therapy. Remarkably, breast cancers can recur after extended periods of clinical remission, implying that at least some re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278ab539c481feae3ab1dae5184dd272
https://europepmc.org/articles/PMC4497740/
https://europepmc.org/articles/PMC4497740/