Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Daniel L Hurdiss"'
Autor:
Chiara Aloise, Jelle G Schipper, Arno van Vliet, Judith Oymans, Tim Donselaar, Daniel L Hurdiss, Raoul J de Groot, Frank J M van Kuppeveld
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011582 (2023)
The nucleocapsid protein N of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enwraps and condenses the viral genome for packaging but is also an antagonist of the innate antiviral defense. It suppresses the integrated stress response (I
Externí odkaz:
https://doaj.org/article/f7de8a47b87c4e9e88b06cd5bac75e80
Autor:
Lisa Bauer, Roberto Manganaro, Birgit Zonsics, Daniel L Hurdiss, Marleen Zwaagstra, Tim Donselaar, Naemi G E Welter, Regina G D M van Kleef, Moira Lorenzo Lopez, Federica Bevilacqua, Thamidur Raman, Salvatore Ferla, Marcella Bassetto, Johan Neyts, Jeroen R P M Strating, Remco H S Westerink, Andrea Brancale, Frank J M van Kuppeveld
Publikováno v:
PLoS Biology, Vol 18, Iss 11, p e3000904 (2020)
There is a great need for antiviral drugs to treat enterovirus (EV) and rhinovirus (RV) infections, which can be severe and occasionally life-threatening. The conserved nonstructural protein 2C, which is an AAA+ ATPase, is a promising target for drug
Externí odkaz:
https://doaj.org/article/89e23fb98cb14c2cbff74c8336bc7f45
Autor:
Joseph S Snowden, Daniel L Hurdiss, Oluwapelumi O Adeyemi, Neil A Ranson, Morgan R Herod, Nicola J Stonehouse
Publikováno v:
PLoS Biology, Vol 18, Iss 3, p e3000649 (2020)
Icosahedral viral capsids must undergo conformational rearrangements to coordinate essential processes during the viral life cycle. Capturing such conformational flexibility has been technically challenging yet could be key for developing rational th
Externí odkaz:
https://doaj.org/article/9d3e1b9c3f2e493eb9f7b4ef1bc203d2
Autor:
Wenjuan Du, Oliver Debski-Antoniak, Dubravka Drabek, Rien van Haperen, Melissa van Dortmondt, Joline van der Lee, Ieva Drulyte, Frank J. M. van Kuppeveld, Frank Grosveld, Daniel L. Hurdiss, Berend-Jan Bosch
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Porcine deltacoronavirus (PDCoV) is an emerging enteric pathogen that has recently been detected in humans. Despite this zoonotic concern, the antigenic structure of PDCoV remains unknown. The virus relies on its spike (S) protein for cell e
Externí odkaz:
https://doaj.org/article/9dcf63e5b3054d1fac1699924a218ec5
Autor:
Chunyan Wang, Rien van Haperen, Javier Gutiérrez-Álvarez, Wentao Li, Nisreen M. A. Okba, Irina Albulescu, Ivy Widjaja, Brenda van Dieren, Raul Fernandez-Delgado, Isabel Sola, Daniel L. Hurdiss, Olalekan Daramola, Frank Grosveld, Frank J. M. van Kuppeveld, Bart L. Haagmans, Luis Enjuanes, Dubravka Drabek, Berend-Jan Bosch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Here, the authors report the isolation and characterization of two human monoclonal antibodies (mAbs) from immunized mice with trimeric spike ectodomains of three human betacoronaviruses HCoV-OC43, SARS-CoV and MERSCoV, and show that while exhibiting
Externí odkaz:
https://doaj.org/article/db6da7f5d9bb4e1c916d69bc00d5ab39
Autor:
Daniel L. Hurdiss, Ieva Drulyte, Yifei Lang, Tatiana M. Shamorkina, Matti F. Pronker, Frank J. M. van Kuppeveld, Joost Snijder, Raoul J. de Groot
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Human coronavirus-HKU1 contains two surface projections called spike and haemagglutinin-esterase (HE), with the latter acting as a receptor-destroying enzyme. Here, the authors use cryo-EM and mass spectrometry to characterise the small, heavily glyc
Externí odkaz:
https://doaj.org/article/e39f8123487b43869c78601f60414a16
Autor:
Vito Thijssen, Daniel L. Hurdiss, Oliver J. Debski-Antoniak, Matthew A. Spence, Charlotte Franck, Alexander Norman, Anupriya Aggarwal, Nadia J. Mokiem, David A. A. van Dongen, Stein W. Vermeir, Minglong Liu, Wentao Li, Marianthi Chatziandreou, Tim Donselaar, Wenjuan Du, Ieva Drulyte, Berend-Jan Bosch, Joost Snijder, Stuart Turville, Richard J. Payne, Colin J. Jackson, Frank J. M. van Kuppeveld, Seino A. K. Jongkees
The ongoing COVID-19 pandemic has had great societal and health consequences. Despite the availability of vaccines, infection rates remain high due to immune evasive Omicron sublineages. Broad-spectrum antivirals are needed to safeguard against emerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bef323aac59161513088436e62791ac
https://dspace.library.uu.nl/handle/1874/429162
https://dspace.library.uu.nl/handle/1874/429162
Autor:
Jim Baggen, Hendrik Jan Thibaut, Daniel L. Hurdiss, Maryam Wahedi, Caleb D. Marceau, Arno L. W. van Vliet, Jan E. Carette, Frank J. M. van Kuppeveld
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Encephalomyocarditis virus (EMCV) is an animal pathogen and an important model organism, whose receptor requirements are poorly understood. Here, we employed a genome-wide haploid genetic screen to identify novel EMCV host factors. In additi
Externí odkaz:
https://doaj.org/article/01a74b9ee28949e48a4b505a3ba38c76
Autor:
Johanna Marsian, Daniel L. Hurdiss, Neil A. Ranson, Anneli Ritala, Richard Paley, Irene Cano, George P. Lomonossoff
Publikováno v:
Frontiers in Plant Science, Vol 10 (2019)
Virus-like particles (VLPs) of the fish virus, Atlantic Cod Nervous necrosis virus (ACNNV), were successfully produced by transient expression of the coat protein in Nicotiana benthamiana plants. VLPs could also be produced in transgenic tobacco BY-2
Externí odkaz:
https://doaj.org/article/575aee837fba44c8908e4c6e061e635b
Autor:
Matti F. Pronker, Robert Creutznacher, Ieva Drulyte, Ruben J.G. Hulswit, Zeshi Li, Frank J.M. van Kuppeveld, Joost Snijder, Yifei Lang, Berend-Jan Bosch, Geert-Jan Boons, Martin Frank, Raoul J. de Groot, Daniel L. Hurdiss
Coronavirus (CoV) spikes mediate receptor binding and membrane fusion, making them prime targets for neutralising antibodies. In the cases of SARS-CoV, SARS-CoV-2, and MERS-CoV, spikes transition freely between open and closed conformations to balanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86593eb6f8d9487226a1b5917189f47f
https://doi.org/10.1101/2023.04.20.536837
https://doi.org/10.1101/2023.04.20.536837