Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Daniel L Gillen"'
Autor:
Rolando Ruiz, Sohail Jahid, Melissa Harris, Diego M Marzese, Francisco Espitia, Priya Vasudeva, Chi-Fen Chen, Sebastien de Feraudy, Jie Wu, Daniel L Gillen, Tatiana B Krasieva, Bruce J Tromberg, William J Pavan, Dave S Hoon, Anand K Ganesan
Publikováno v:
PLoS Genetics, Vol 13, Iss 7, p e1006913 (2017)
Genes and pathways that allow cells to cope with oncogene-induced stress represent selective cancer therapeutic targets that remain largely undiscovered. In this study, we identify a RhoJ signaling pathway that is a selective therapeutic target for B
Externí odkaz:
https://doaj.org/article/582d4bd0a5b74af2839786a23753eee3
Autor:
Elyse K Paterson, Thomas J Fielder, Grant R MacGregor, Shosuke Ito, Kazumasa Wakamatsu, Daniel L Gillen, Victoria Eby, Raymond E Boissy, Anand K Ganesan
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143702 (2015)
The mechanisms that lead to variation in human skin and hair color are not fully understood. To better understand the molecular control of skin and hair color variation, we modulated the expression of Tyrosinase (Tyr), which controls the rate-limitin
Externí odkaz:
https://doaj.org/article/f686141cdd10446dbe864532116f42bf
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-5 (2023)
Abstract Background Participant retention is a key factor that affects clinical trial integrity. Trial protocols estimate attrition as a function of sample size calculations. Alzheimer’s disease (AD) is an area of active treatment development. We a
Externí odkaz:
https://doaj.org/article/5b04dc8699cd45708b4b9f8fbdb8e3fa
Autor:
Giuseppe Astarita, Kwang-Mook Jung, Nicole C Berchtold, Vinh Q Nguyen, Daniel L Gillen, Elizabeth Head, Carl W Cotman, Daniele Piomelli
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12538 (2010)
Reduced brain levels of docosahexaenoic acid (C22:6n-3), a neurotrophic and neuroprotective fatty acid, may contribute to cognitive decline in Alzheimer's disease. Here, we investigated whether the liver enzyme system that provides docosahexaenoic ac
Externí odkaz:
https://doaj.org/article/cefc8775d5944be18567c6dc7aa2cf69
Autor:
Roy S. Zawadzki, Joshua D. Grill, Daniel L. Gillen, and for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
BMC Medical Research Methodology, Vol 23, Iss 1, Pp 1-24 (2023)
Abstract To estimate causal effects, analysts performing observational studies in health settings utilize several strategies to mitigate bias due to confounding by indication. There are two broad classes of approaches for these purposes: use of confo
Externí odkaz:
https://doaj.org/article/6296f20c76b24a2faa1cd455fc92da91
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-9 (2023)
Abstract Background Timely accrual of a representative sample is a key factor in whether Alzheimer’s disease (AD) clinical trials successfully answer the scientific questions under study. Studies in other fields have observed that, over time, recru
Externí odkaz:
https://doaj.org/article/afdf4e1a55b540678d277b7fe1b8fdad
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 4, Pp n/a-n/a (2023)
Abstract INTRODUCTION Alzheimer's disease (AD) trials require enrollment with an informant. METHODS We assessed relationships between informant replacement and Alzheimer's Disease Cooperative Study Activities of Daily Living (ADCS‐ADL) scores acros
Externí odkaz:
https://doaj.org/article/7959d1c5396148068726c7d63efad7eb
Publikováno v:
Stat Biosci
Assessing the impact of complex interventions on measurable health outcomes is a growing concern in health care and health policy. Interrupted time series (ITS) designs borrow from traditional case-crossover designs and function as quasi-experimental
Autor:
Melissa Soohoo, Hamid Moradi, Yoshitsugu Obi, Connie M. Rhee, Elvira O. Gosmanova, Miklos Z. Molnar, Moti L. Kashyap, Daniel L. Gillen, Csaba P. Kovesdy, Kamyar Kalantar‐Zadeh, Elani Streja
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 6 (2019)
Background Although studies have shown that statin therapy in patients with non–dialysis‐dependent chronic kidney disease was associated with a lower risk of death, this was not observed in dialysis patients newly initiated on statins. It is uncl
Externí odkaz:
https://doaj.org/article/492d7d458f5145dab67b7b0892ff82de
Autor:
Steven M. Lipkin, Daniel W. Rosenberg, Eva Szabo, Luz Maria Rodriguez, Rachel Gonzalez, Jinah Chung, Vanessa Wong, Myra Arcilla, Zhiliang Huang, Asmita Bhattacharya, Chris Tucker, Allen Mo, Wen-Pin Chen, Richard Benya, Robert Carroll, Jason A. Zell, Timothy R. Morgan, Frank L. Meyskens, Daniel L. Gillen
Supplemental Methods and Materials. ACF Phospho-ERK and ERK Level Quantification.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8d026c6b15d98e566c3c2512cb390a
https://doi.org/10.1158/1940-6207.22526415.v1
https://doi.org/10.1158/1940-6207.22526415.v1