Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Daniel L Cox"'
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229319 (2020)
Biomolecular self-assembly is an emerging bottom-up approach for the synthesis of novel nanomaterials. DNA and viruses have both been used to create scaffolds but the former lacks chemical diversity and the latter lack spatial control. To date, the u
Externí odkaz:
https://doaj.org/article/a627bb4a5f42475dba21b28ca85e0403
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104965 (2014)
We present a coarse-grained two dimensional mechanical model for the microtubule-tau bundles in neuronal axons in which we remove taus, as can happen in various neurodegenerative conditions such as Alzheimers disease, tauopathies, and chronic traumat
Externí odkaz:
https://doaj.org/article/1000eb0db8ea43de9f6276c2e67645d9
Autor:
Georgina Gonzalez-Isunza, M. Zaki Jawaid, Pengyu Liu, Daniel L. Cox, Mariel Vazquez, Javier Arsuaga
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Establishing the host range for novel viruses remains a challenge. Here, we address the challenge of identifying non-human animal coronaviruses that may infect humans by creating an artificial neural network model that learns from spike prot
Externí odkaz:
https://doaj.org/article/b2c2e98ae64347ba969d848fbde6139e
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT The recent emergence of the omicron variant of the SARS-CoV-2 virus with large numbers of mutations has raised concern about a potential new surge in infections. Here we use molecular dynamics to study the biophysics of the interface of the
Externí odkaz:
https://doaj.org/article/ede9c8ebe84b44f889b92edc1296f32b
The recent emergence of the omicron variant of the SARS-CoV-2 virus with large numbers of mutations has raised concern about a potential new surge in infections. Here we use molecular dynamics to study the biophysics of the interface of the omicron s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc19370465b71815b051c75c7ed14a3b
https://doi.org/10.1101/2021.12.14.472704
https://doi.org/10.1101/2021.12.14.472704
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 80:1299-1307
We employ all-atom structure-based models with a force field with multiple energetic basins for the C-terminal (residues 166-226) of the mammalian prion protein. One basin represents the known alpha-helical (αH) structure while the other represents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22b43af09fb6704c3c562ba42b7e37f
https://doi.org/10.1002/prot.24026
https://doi.org/10.1002/prot.24026
Uridine 5′-diphosphate-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (LpxA) catalyzes a reversible reaction for adding anO-acyl group to the GlcNAc in UDP-GlcNAc in the first step of lipid A biosynthesis. Lipid A constitutes a major component of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2013de838175087f5b1370f97629b40
https://europepmc.org/articles/PMC4427197/
https://europepmc.org/articles/PMC4427197/
Autor:
David Pines, Daniel L. Cox
Publikováno v:
MRS Bulletin. 30:425-432
In the study of matter, both living and inanimate, the breakthrough discoveries and most scientists' intellectual obsessions often flow from what we call emergent behavior: phenomena not readily predictable from a detailed knowledge of the material s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6d33f8f72d2bd7243f629b9ba1a7423
https://doi.org/10.1557/mrs2005.118
https://doi.org/10.1557/mrs2005.118
Publikováno v:
MRS Bulletin. 29:963-966
Many of the key challenges and opportunities in the study of matter involve complex and collective phenomena in which many parts exhibit organization without a central instruction set or clock. At the core of this enterprise in the study of matter is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29c78c1bbd42fcbdc41e047cd588aab5
https://doi.org/10.1557/mrs2004.268
https://doi.org/10.1557/mrs2004.268