Zobrazeno 1 - 10
of 294
pro vyhledávání: '"Daniel L, Gustafson"'
Autor:
Jacob M. Siewert, Daniel L. Gustafson, Kristen M. Weishaar, Annie M. Galloway, Douglas H. Thamm
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 37, Iss 6, Pp 2402-2409 (2023)
Abstract Background This study was performed to determine the ability to escalate drug doses in a 15‐week CHOP protocol in dogs with multicentric lymphoma. Hypothesis We hypothesized that at least 50% of dogs could successfully be escalated in at l
Externí odkaz:
https://doaj.org/article/3c8e0cc1ce1642159afb737af85fd9b0
Autor:
Aaron J. Rozental, Brooke G. Weisbeck, Isabella Corsato Alvarenga, Daniel L. Gustafson, Breonna R. Kusick, Sangeeta Rao, Lisa R. Bartner, Stephanie McGrath
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 37, Iss 6, Pp 2291-2300 (2023)
Abstract Background Approximately 30% of dogs with idiopathic epilepsy (IE) are drug‐resistant. Recent studies have suggested cannabidiol (CBD) may be an effective anticonvulsant in dogs with IE. Objective To evaluate the addition of CBD to antisei
Externí odkaz:
https://doaj.org/article/e2d446a91af1436a8711204075e576fb
Autor:
Kristin M. Zersen, Angela Molli, Brooke G. Weisbeck, Samantha Fedotova, Jessica M. Quimby, Daniel L. Gustafson, Sarah B. Shropshire
Publikováno v:
Veterinary Sciences, Vol 11, Iss 3, p 112 (2024)
The purpose of this study was to evaluate plasma ondansetron (OND) concentrations in a population of dogs with naturally occurring nausea after oral OND administration. Twenty-four dogs were randomly assigned to receive one of the following doses of
Externí odkaz:
https://doaj.org/article/b0f3dda08606495f9d697c7769931568
Autor:
Sandra Witta, Keagan P. Collins, Dominique A. Ramirez, Joshua D. Mannheimer, Luke A. Wittenburg, Daniel L. Gustafson
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 1, Pp n/a-n/a (2023)
Abstract Vinblastine (VBL) is a vinca alkaloid‐class cytotoxic chemotherapeutic that causes microtubule disruption and is typically used to treat hematologic malignancies. VBL is characterized by a narrow therapeutic index, with key dose‐limiting
Externí odkaz:
https://doaj.org/article/61d9b71b4f14428898236b51eb463339
Autor:
Sunetra Das, Rupa Idate, Daniel P. Regan, Jared S. Fowles, Susan E. Lana, Douglas H. Thamm, Daniel L. Gustafson, Dawn L. Duval
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Sunetra Das et al. combine genetic and immunohistochemistry data to characterize mutation and expression profiles of canine osteosarcoma and its association with clinical outcomes. Their results provide further insight into the pathogenesis and poten
Externí odkaz:
https://doaj.org/article/40f18b0edf8e479584b48c155d3b6eee
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-18 (2021)
Abstract Background One of the current directions of precision medicine is the use of computational methods to aid in the diagnosis, prognosis, and treatment of disease based on data driven approaches. For instance, in oncology, there has been a part
Externí odkaz:
https://doaj.org/article/54890129fb254292ba7c8445d19cea28
Autor:
Jamie L Dombach, Joaquin Lj Quintana, Samual C Allgood, Toni A Nagy, Daniel L Gustafson, Corrella S Detweiler
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010606 (2022)
As pathogenic bacteria become increasingly resistant to antibiotics, antimicrobials with mechanisms of action distinct from current clinical antibiotics are needed. Gram-negative bacteria pose a particular problem because they defend themselves again
Externí odkaz:
https://doaj.org/article/cedae983f77d4c83a4f3f7ca5ecd1b1d
Autor:
Tanya J. Applegate, Greta M. Krafsur, June A. Boon, Hui Zhang, Min Li, Timothy N. Holt, S. Kelly Ambler, Benjamin A. Abrams, Daniel L. Gustafson, Karsten Bartels, Franklyn B. Garry, Kurt R. Stenmark, R. Dale Brown
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Pulmonary hypertension (PH) is an incurable condition in humans; driven by pulmonary vascular remodeling partially mediated by epigenetic mechanisms; and leading to right ventricular hypertrophy, failure, and death. We hypothesized that targeting chr
Externí odkaz:
https://doaj.org/article/387cb974a6c741868b4c75a56eda2db7
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Cannabidiol (CBD), the major non-psychoactive compound found in cannabis, is frequently used both as a nutraceutical and therapeutic. Despite anecdotal evidence as an anticancer agent, little is known about the effect CBD has on cancer cells. Given t
Externí odkaz:
https://doaj.org/article/e6dd498d76044e878519960144972308
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-18 (2019)
Abstract Background The availability and generation of large amounts of genomic data has led to the development of a new paradigm in cancer treatment emphasizing a precision approach at the molecular and genomic level. Statistical modeling techniques
Externí odkaz:
https://doaj.org/article/0ddb43d509eb49ceb280b87534ec8652