Výsledky vyhledávání - "Daniel Kwaku"

Akademický článek

Identification of an H-Ras nanocluster disrupting peptide

Autor: Candy Laura Steffen, Ganesh babu Manoharan, Karolina Pavic, Alejandro Yeste-Vázquez, Matias Knuuttila, Neha Arora, Yong Zhou, Harri Härmä, Anthoula Gaigneaux, Tom N. Grossmann, Daniel Kwaku Abankwa

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)

Abstract Hyperactive Ras signalling is found in most cancers. Ras proteins are only active in membrane nanoclusters, which are therefore potential drug targets. We previously showed that the nanocluster scaffold galectin-1 (Gal1) enhances H-Ras nanoc

Externí odkaz: https://doaj.org/article/824fba21fa7f4eef9a59a3a33f13cb35

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Akademický článek

Protocol to measure and analyze protein interactions in mammalian cells using bioluminescence resonance energy transfer

Autor: Carla Jane Duval, Candy Laura Steffen, Karolina Pavic, Daniel Kwaku Abankwa

Publikováno v: STAR Protocols, Vol 5, Iss 4, Pp 103348- (2024)

Summary: Bioluminescence resonance energy transfer (BRET) allows to quantitate protein interactions in intact cells. Here, we present a protocol for measuring BRET due to transient interactions of oncogenic K-RasG12V in plasma membrane nanoclusters o

Externí odkaz: https://doaj.org/article/7906e77f87bf40e7b0cf23676a2b170e

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Akademický článek

RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation

Autor: Rohan Chippalkatti, Bianca Parisi, Farah Kouzi, Christina Laurini, Nesrine Ben Fredj, Daniel Kwaku Abankwa

Publikováno v: European Journal of Cell Biology, Vol 103, Iss 2, Pp 151425- (2024)

The RAS-MAPK-pathway is aberrantly regulated in cancer and developmental diseases called RASopathies. While typically the impact of Ras on the proliferation of various cancer cell lines is assessed, it is poorly established how Ras affects cellular d

Externí odkaz: https://doaj.org/article/1450c331bc2c419c91c59ee4730bc14e

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Akademický článek

A flow-cytometry-based pipeline for the rapid quantification of C2C12 cell differentiation

Autor: Bianca Parisi, Maxime Sünnen, Rohan Chippalkatti, Daniel Kwaku Abankwa

Publikováno v: STAR Protocols, Vol 4, Iss 4, Pp 102637- (2023)

Summary: The C2C12 cell line represents a simple in vitro model for cell differentiation. Here, we present a flow-cytometry-based pipeline to quantitate C2C12 cell differentiation based on myosin heavy-chain marker expression. We describe steps for c

Externí odkaz: https://doaj.org/article/876cd3eb14f24d24b3ac611ecb5be266

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Akademický článek

Macro- and Microelemental Composition and Toxicity of Unsweetened Natural Cocoa Powder in Sprague-Dawley Rats

Autor: Isaac Julius Asiedu-Gyekye, Samuel Frimpong-Manso, Benoit Banga N’guessan, Mahmood Abdulai Seidu, Paul Osei-Prempeh, Daniel Kwaku Boamah

Publikováno v: Journal of Toxicology, Vol 2016 (2016)

Unsweetened natural cocoa powder (UNCP) is a pulverized high-grade powder of compressed solid blocks which remains after extraction. Little scientific data is available concerning its safety despite the presence of potential toxic elements. Elemental

Externí odkaz: https://doaj.org/article/4c97091134cb427e84ec0129e134eec9

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