Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Daniel Kornitzer"'
Autor:
Mariel Pinsky, Daniel Kornitzer
Publikováno v:
Journal of Fungi, Vol 10, Iss 1, p 83 (2024)
Candida albicans is a major human pathogenic fungus that is distinguished by its capability to switch from a yeast to a hyphal morphology under different conditions. Here, we analyze the cellular effects of high concentrations of the iron chelator ba
Externí odkaz:
https://doaj.org/article/f32d769f2d514e4cb0f304bae2dd1f6b
Autor:
Udita Roy, Shir Yaish, Ziva Weissman, Mariel Pinsky, Sunanda Dey, Guy Horev, Daniel Kornitzer
Publikováno v:
eLife, Vol 11 (2022)
Heme can serve as iron source in many environments, including the iron-poor animal host environment. The fungal pathobiont Candida albicans expresses a family of extracellular CFEM hemophores that capture heme from host proteins and transfer it acros
Externí odkaz:
https://doaj.org/article/88b1c8fdd0b34409907e3834e0ae535a
Autor:
Natalie Andrawes, Ziva Weissman, Mariel Pinsky, Shilat Moshe, Judith Berman, Daniel Kornitzer
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010390 (2022)
Heme (iron-protoporphyrin IX) is an essential but potentially toxic cellular cofactor. While most organisms are heme prototrophs, many microorganisms can utilize environmental heme as iron source. The pathogenic yeast Candida albicans can utilize hos
Externí odkaz:
https://doaj.org/article/010a320e88514774aab39220eafa7c64
Candida albicans Induces Cross-Kingdom miRNA Trafficking in Human Monocytes To Promote Fungal Growth
Autor:
Luke D. Halder, Svitlana Babych, Diana I. Palme, Elham Mansouri-Ghahnavieh, Lia Ivanov, Victory Ashonibare, Daniela Langenhorst, Bhupesh Prusty, Günter Rambach, Melissa Wich, Nora Trinks, Matthew G. Blango, Daniel Kornitzer, Ulrich Terpitz, Cornelia Speth, Berit Jungnickel, Niklas Beyersdorf, Peter F. Zipfel, Axel A. Brakhage, Christine Skerka
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT In response to infections, human immune cells release extracellular vesicles (EVs) that carry a situationally adapted cocktail of proteins and nucleic acids, including microRNAs (miRNAs), to coordinate the immune response. In this study, we
Externí odkaz:
https://doaj.org/article/66c93ab97dcd4f169fa55e314a6c98f3
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT A large portion of biological iron is found in the form of an iron-protoporphyrin IX complex, or heme. In the human host environment, which is exceptionally poor in free iron, heme iron, particularly from hemoglobin, constitutes a major sour
Externí odkaz:
https://doaj.org/article/567c8e8d6a5b475f89041c9a98f5876a
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Candida albicans is an opportunistic pathogen, typically found as a benign commensal yeast living on skin and mucosa, but poised to invade injured tissue to cause local infections. In debilitated and immunocompromised individuals, C. albican
Externí odkaz:
https://doaj.org/article/4f5c25110a054679baebfc9be57e11a1
Autor:
Hagit Bar-Yosef, Tsvia Gildor, Bernardo Ramírez-Zavala, Christian Schmauch, Ziva Weissman, Mariel Pinsky, Rawi Naddaf, Joachim Morschhäuser, Robert A. Arkowitz, Daniel Kornitzer
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
The human pathogenic fungus Candida albicans can switch between yeast and hyphal morphologies as a function of environmental conditions and cellular physiology. The yeast-to-hyphae morphogenetic switch is activated by well-established, kinase-based s
Externí odkaz:
https://doaj.org/article/2d8752d1ee3e46e986d5d61b4878a074
Publikováno v:
mSphere, Vol 2, Iss 2 (2017)
ABSTRACT The ability to switch between proliferation as yeast cells and development into hyphae is a hallmark of Candida albicans. The switch to hyphal morphogenesis depends on external inducing conditions, but its efficiency is augmented in stationa
Externí odkaz:
https://doaj.org/article/260b50c173ef4fc382a573160d1c76f4
Autor:
Daniel Kornitzer
Publikováno v:
Journal of Fungi, Vol 5, Iss 1, p 21 (2019)
Candida albicans is a human commensal fungus that is able to assume several morphologies, including yeast, hyphal, and pseudohyphal. Under a range of conditions, C. albicans performs a regulated switch to the filamentous morphology, characterized by
Externí odkaz:
https://doaj.org/article/b13e96cb8fb74b799c046742b6673863
Autor:
Galit Kuznets, Elena Vigonsky, Ziva Weissman, Daniela Lalli, Tsvia Gildor, Sarah J Kauffman, Paola Turano, Jeffrey Becker, Oded Lewinson, Daniel Kornitzer
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004407 (2014)
Iron scavenging constitutes a crucial challenge for survival of pathogenic microorganisms in the iron-poor host environment. Candida albicans, like many microbial pathogens, is able to utilize iron from hemoglobin, the largest iron pool in the host's
Externí odkaz:
https://doaj.org/article/efca61c556164c5a99eac2c754b90f59