Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Daniel Keifenheim"'
Autor:
Sanjana Sundararajan, Hyewon Park, Shinji Kawano, Marnie Johansson, Bunu Lama, Tomoko Saito-Fujita, Noriko Saitoh, Alexei Arnaoutov, Mary Dasso, Zhengqiang Wang, Daniel Keifenheim, Duncan J. Clarke, Yoshiaki Azuma
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106743- (2023)
Summary: DNA Topoisomerase IIα (TopoIIα) decatenates sister chromatids, allowing their segregation in mitosis. Without the TopoIIα Strand Passage Reaction (SPR), chromosome bridges and ultra-fine DNA bridges (UFBs) arise in anaphase. The TopoIIα
Externí odkaz:
https://doaj.org/article/19bb8937fd674b67b4767f3d9fe007bf
Size-Dependent Expression of the Fission Yeast Cdc13 Cyclin is Conferred by Translational Regulation
Autor:
Samirul Bashir, Xi-Ming Sun, Yixuan Zhao, Nuria G. Martínez-Illescas, Isabella Gallego-López, Lauren Guerrero Negrón, Daniel Keifenheim, Tatiana Karadimitriou, Thi Tran, Mary Pickering, Samuel Marguerat, Nicholas Rhind
Two fission yeast mitotic activators, Cdc13 and Cdc25, have been shown to increase in concentration in correlation with cell size, and have been proposed to thereby regulate cell size at division. Here, we show that the expression of both Cdc13 and C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::079d43f6d7ee17496186f810acadaa15
https://doi.org/10.1101/2023.01.16.524304
https://doi.org/10.1101/2023.01.16.524304
Autor:
Makoto Michael Yoshida, Victoria A. Hassebroek, Nootan Pandey, Caitlin Soroka, Daniel Keifenheim, Yoshiaki Azuma, Duncan J. Clarke
Publikováno v:
The Journal of Cell Biology
To prevent chromosome missegregation, a metaphase checkpoint is activated when topoisomerase II is catalytically inhibited and DNA catenations persist. Pandey et al. dissect the key molecular events triggering this regulatory system.
Topoisomera
Topoisomera
Autor:
María Arroyo, Duncan J. Clarke, Juan Alberto Marchal, Ana Cañuelo, Ryoko Kuriyama, Antonio Sánchez, Daniel Keifenheim, Marc Trimborn
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
MCPH1 gene, mutated in primary microcephaly, regulates cell progression into mitosis. While this role has been extensively investigated in the context of DNA damage, its function during unperturbed cell cycles has been given less attention. Here we h
Autor:
Ana Cañuelo, Jesús Calahorra, J. Alberto Marchal, Duncan J. Clarke, Israel Guerrero, Antonio Sánchez, Daniel Keifenheim, Ryoko Kuriyama, María Arroyo
Cellular checkpoints controlling entry into mitosis monitor the integrity of the DNA and delay mitosis onset until the alteration is fully repaired. However, this canonical response can weaken, leading to a spontaneous bypass of the checkpoint, a pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3aacef073c8dc09ae37bba3d38d7bc3
https://europepmc.org/articles/PMC6593890/
https://europepmc.org/articles/PMC6593890/
Autor:
Jeff Bachant, Duncan J. Clarke, Soumya Mukherjee, Marnie Johansson, Daniel Keifenheim, Jeremy M. Chacón, Melissa K. Gardner, Heather Edgerton
Publikováno v:
The Journal of Cell Biology
The C-terminal domain (CTD) of Topo II is dispensable for its catalytic activity yet essential for Topo II function in chromosome segregation during mitosis. Here, Edgerton et al. resolve the role of the Topo II CTD during mitosis in yeast, showing t
Publikováno v:
Genetics
Commitment to mitosis is regulated by cyclin-dependent kinase (CDK) activity. In the fission yeastSchizosaccharomyces pombe, the major B-type cyclin, Cdc13, is necessary and sufficient to drive mitotic entry. Furthermore, Cdc13 is also sufficient to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd5c9826b8e6ae632e397b17d0d9bb4
https://doi.org/10.1101/213330
https://doi.org/10.1101/213330
Autor:
Nicholas Rhind, Samuel Marguerat, Xi-Ming Sun, Edridge D'Souza, Daniel Keifenheim, Mira Magner, Michael B. Mayhew, Makoto J. Ohira
Publikováno v:
1497.e4
Summary Proper cell size is essential for cellular function. Nonetheless, despite more than 100 years of work on the subject, the mechanisms that maintain cell-size homeostasis are largely mysterious [1]. Cells in growing populations maintain cell si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789310589e6ae6d00caf112cd1ca12b8
https://europepmc.org/articles/PMC5479637/
https://europepmc.org/articles/PMC5479637/
Autor:
Daniel Keifenheim, Xi-Ming Sun, Edridge D'Souza, Makoto J. Ohira, Mira Magner, Michael B. Mayhew, Marguerat Samuel, Nicholas Rhind
SummaryProper cell size is essential for cellular function (Hall et al., 2004). Nonetheless, despite more than 100 years of work on the subject, the mechanisms that maintain cell size homeostasis are largely mysterious (Marshall et al., 2012). Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0021df1ea5310bf7ceff647523c72e4
https://doi.org/10.1101/078592
https://doi.org/10.1101/078592
Publikováno v:
American Journal of Potato Research. 83:233-239
Anthocyanins are a class of flavonoids that are responsible for the pigmentation of red potato periderm. The cDNAs of two genes were cloned from ‘Norland’ periderm and, based on their sequence similarity to genes in various databases, were identi