Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Daniel Kavanagh"'
Autor:
Filippos Porichis, Meghan Hart, Lucie Barblu, Jennifer Zupkosky, Daniel Kavanagh, Daniel Kaufmann
Publikováno v:
The Journal of Immunology. 190:118.5-118.5
One of the major impediments of HIV infection is the abnormally high levels of immune activation that contributes to immune dysregulation and impairs viral clearance. While IFNγ secretion is used as a marker of the functional state of T lymphocytes
Autor:
Yovana Pacheco, Anna McLean, Janine Rohrbach, Filippos Porichis, Daniel Kaufmann, Daniel Kavanagh
Publikováno v:
The Journal of Immunology. 190:173.12-173.12
Antigen-experienced T cells express a wide variety of costimulatory molecules, some of which can contribute to activating, inhibitory, or exhaustion pathways depending on context. In particular 2B4 (CD244/ SLAMf4) has been shown to be capable of eith
Treatment of multiple sclerosis with T-cell receptor peptides: results of a double-blind pilot trial
Autor:
Ruth H. Whitham, Michele Mass, Halina Offner, Arthur A. Vandenbark, Daniel Kavanagh, Abigail C. Buenafe, Shelley A. Cooper, George A. Hashim, Diane Liefeld, Yuan K. Chou, Dennis Bourdette
Publikováno v:
Nature medicine. 2(10)
A T-cell receptor (TCR) peptide vaccine from the V beta 5.2 sequence expressed in multiple sclerosis (MS) plaques and on myelin basic protein (MBP)-specific T cells boosted peptide-reactive T cells in patients with progressive MS. Vaccine responders
Autor:
Filippos Porichis, Douglas Kwon, Zupkosky Jennifer, Meghan Hart, Ashley McMullen, Gordon Freeman, Daniel Kavanagh, Daniel Kaufmann
Publikováno v:
The Journal of Immunology. 188:105.2-105.2
Blockade of the PD-1 or IL-10 pathways can restore antigen-specific T cell functions in chronic infections and cancer. PD-1 blockade is currently evaluated in oncology trials and is also considered in HIV infection. It is thus crucial to define the i
Publikováno v:
The Journal of Immunology. 186:105.43-105.43
CD8+ cytolytic T cells can suppress HIV replication by a variety of lytic and nonlytic mechanisms, and the relative clinical importance of particular CTL functions is not fully understood. Therefore studies have utilized various in vitro viral suppre
Autor:
Daniel Kavanagh
Publikováno v:
Journal of Clinical Virology. 12:131