Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Daniel Kahne"'
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Most bacteria have a peptidoglycan cell wall that determines their cell shape and helps them resist osmotic lysis. Peptidoglycan synthesis depends on the translocation of the lipid-linked precursor lipid II across the cytoplasmic membrane by
Externí odkaz:
https://doaj.org/article/8938d3f011084adfa3c1825bb5f0f001
Publikováno v:
eLife, Vol 8 (2019)
The β-barrel assembly machine (Bam) complex in Gram-negative bacteria and its counterparts in mitochondria and chloroplasts fold and insert outer membrane β-barrel proteins. BamA, an essential component of the complex, is itself a β-barrel and is
Externí odkaz:
https://doaj.org/article/95952a2ea15840d88ea48c42aed42402
Autor:
Brent W. Simpson, Karanbir S. Pahil, Tristan W. Owens, Emily A. Lundstedt, Rebecca M. Davis, Daniel Kahne, Natividad Ruiz
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT ATP-binding cassette (ABC) transporters constitute a large family of proteins present in all domains of life. They are powered by dynamic ATPases that harness energy from binding and hydrolyzing ATP through a cycle that involves the closing
Externí odkaz:
https://doaj.org/article/e5f9ae4be9c9430f83be36fa788bf4ff
Autor:
Brent W. Simpson, Tristan W. Owens, Matthew J. Orabella, Rebecca M. Davis, Janine M. May, Sunia A. Trauger, Daniel Kahne, Natividad Ruiz
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
ABSTRACT The surface of most Gram-negative bacteria is covered with lipopolysaccharide (LPS), creating a permeability barrier against toxic molecules, including many antimicrobials. To assemble LPS on their surface, Gram-negative bacteria must extrac
Externí odkaz:
https://doaj.org/article/70fd34c5f4c0484c83e80bbffb5c41d8
Autor:
Marcin Grabowicz, Dorothee Andres, Matthew D Lebar, Goran Malojčić, Daniel Kahne, Thomas J Silhavy
Publikováno v:
eLife, Vol 3 (2014)
The lipopolysaccharide (LPS) forms the surface-exposed leaflet of the outer membrane (OM) of Gram-negative bacteria, an organelle that shields the underlying peptidoglycan (PG) cell wall. Both LPS and PG are essential cell envelope components that ar
Externí odkaz:
https://doaj.org/article/3f87990e42e34d8e8767d7d185821ac9
Publikováno v:
Angewandte Chemie.
Publikováno v:
Chem Rev
The peptidoglycan (PG) cell wall is an extra-cytoplasmic glycopeptide polymeric structure that protects bacteria from osmotic lysis and determines cellular shape. Since the cell wall surrounds the cytoplasmic membrane, bacteria must add new material
Publikováno v:
J Am Chem Soc
Antibiotics to treat drug-resistant Gram-negative infections are urgently needed but challenging to discover. Using a cell-based screen, we identified a simple secondary amine that inhibited the growth of wild-type Escherichia coli and Acinetobacter
Autor:
Julia E. Page, Marina Santiago, Daniel Kahne, Suzanne Walker, Kaitlin Schaefer, Tristan W. Owens
Publikováno v:
Nature microbiology
Bacteria are encapsulated by a peptidoglycan cell wall that is essential for their survival1. During cell wall assembly, a lipid-linked disaccharide–peptide precursor called lipid II is polymerized and cross-linked to produce mature peptidoglycan.
Autor:
Sofia Melnyk, Anastasia Stepanyshyn, Oleksandr Yushchuk, Michael Mandler, Iryna Ostash, Oksana Koshla, Victor Fedorenko, Daniel Kahne, Bohdan Ostash
Publikováno v:
Appl Microbiol Biotechnol
Streptomyces roseochromogenes NRRL 3504 is best known as a producer of clorobiocin, a DNA replication inhibitor from the aminocoumarin family of antibiotics. This natural product currently draws attention as a promising adjuvant for co-application wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321655e46364cc4812b2bf375d2dd1e5
https://europepmc.org/articles/PMC9528727/
https://europepmc.org/articles/PMC9528727/