Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Daniel K. Nomura"'
Autor:
Peixiang Zhang, Joseph J. Munier, Carrie B. Wiese, Laurent Vergnes, Jenny C. Link, Fahim Abbasi, Emilio Ronquillo, Katherine Scheker, Antonio Muñoz, Yu-Lin Kuang, Elizabeth Theusch, Meng Lu, Gabriela Sanchez, Akinyemi Oni-Orisan, Carlos Iribarren, Michael J. McPhaul, Daniel K. Nomura, Joshua W. Knowles, Ronald M. Krauss, Marisa W. Medina, Karen Reue
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glu
Externí odkaz:
https://doaj.org/article/332ede39ee3b4894add02807a1a4ed96
Autor:
Melissa Lim, Thang Do Cong, Lauren M. Orr, Ethan S. Toriki, Andrew C. Kile, James W. Papatzimas, Elijah Lee, Yihan Lin, Daniel K. Nomura
Publikováno v:
ACS Central Science, Vol 10, Iss 7, Pp 1318-1331 (2024)
Externí odkaz:
https://doaj.org/article/6e1507b384184c3cb0cfdba41ee1c091
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Cysteine has been exploited as the binding site of covalent drugs. Its high sensitivity to oxidation is also important for regulating cellular processes. To identify new ligandable cysteines which can be hotspots for therapy and to better st
Externí odkaz:
https://doaj.org/article/db8e17aa532449799f521193015c3d3a
Autor:
Ethan S. Toriki, James W. Papatzimas, Kaila Nishikawa, Dustin Dovala, Andreas O. Frank, Matthew J. Hesse, Daniela Dankova, Jae-Geun Song, Megan Bruce-Smythe, Heidi Struble, Francisco J. Garcia, Scott M. Brittain, Andrew C. Kile, Lynn M. McGregor, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Daniel K. Nomura
Publikováno v:
ACS Central Science, Vol 9, Iss 8, Pp 1702-1702 (2023)
Externí odkaz:
https://doaj.org/article/45f60932a33347c4abe0263c84aaeafc
Autor:
Candice B. Herber, William C. Krause, Liping Wang, James R. Bayrer, Alfred Li, Matthew Schmitz, Aaron Fields, Breanna Ford, Zhi Zhang, Michelle S. Reid, Daniel K. Nomura, Robert A. Nissenson, Stephanie M. Correa, Holly A. Ingraham
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Estrogen promotes negative energy balance and preserves skeletal physiology. Here the authors show that loss of estrogen signalling after ablating estrogen receptor alpha (ERa) in specific hypothalamic neuronal populations leads to a marked sex-depen
Externí odkaz:
https://doaj.org/article/e716ce14ed5d4a069d7f3a182f6e641a
Autor:
Ofer Moldavski, Peter-James H. Zushin, Charles A. Berdan, Robert J. Van Eijkeren, Xuntian Jiang, Mingxing Qian, Daniel S. Ory, Douglas F. Covey, Daniel K. Nomura, Andreas Stahl, Ethan J. Weiss, Roberto Zoncu
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100051- (2021)
Oxysterols are oxidized derivatives of cholesterol that play regulatory roles in lipid biosynthesis and homeostasis. How oxysterol signaling coordinates different lipid classes such as sterols and triglycerides remains incompletely understood. Here,
Externí odkaz:
https://doaj.org/article/486839a449b44a929c2b2c5b68c4be5b
Publikováno v:
mSphere, Vol 4, Iss 6 (2019)
ABSTRACT Gram-negative bacteria in the order Rickettsiales have an obligate intracellular growth requirement, and some species cause human diseases such as typhus and spotted fever. The bacteria have evolved a dependence on essential nutrients and me
Externí odkaz:
https://doaj.org/article/53f1d931ef4c45f28b2d436f73249013
Publikováno v:
mSphere, Vol 4, Iss 6 (2019)
Externí odkaz:
https://doaj.org/article/efeeeb2772f44258833317c5baa5968d
Autor:
Justin A. De Leon, Jiazhang Qiu, Christopher J. Nicolai, Jessica L. Counihan, Kevin C. Barry, Li Xu, Rosalie E. Lawrence, Brian M. Castellano, Roberto Zoncu, Daniel K. Nomura, Zhao-Qing Luo, Russell E. Vance
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2031-2038 (2017)
All pathogens must acquire nutrients from their hosts. The intracellular bacterial pathogen Legionella pneumophila, the etiological agent of Legionnaires’ disease, requires host amino acids for growth within cells. The mechanistic target of rapamyc
Externí odkaz:
https://doaj.org/article/5471c9ca16a2435a881c2dc09deba9c1
Autor:
Maxwell A. Ruby, Julie Massart, Devon M. Hunerdosse, Milena Schönke, Jorge C. Correia, Sharon M. Louie, Jorge L. Ruas, Erik Näslund, Daniel K. Nomura, Juleen R. Zierath
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 636-646 (2017)
Serine hydrolases are a large family of multifunctional enzymes known to influence obesity. Here, we performed activity-based protein profiling to assess the functional level of serine hydrolases in liver biopsies from lean and obese humans in order
Externí odkaz:
https://doaj.org/article/aa11d88b9e6d4a64a80f36f80d98b06d