Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Daniel K. Afosah"'
Autor:
Kayla T. Vu, Srabani Kar, Navneet Goyal, Madhusoodanan Mottamal, Daniel K. Afosah, Rami A. Al-Horani
Publikováno v:
ACS Omega, Vol 9, Iss 28, Pp 31105-31119 (2024)
Externí odkaz:
https://doaj.org/article/d7422103c02e45bf9c73f9d0a6bf9b0a
Autor:
Ma’Lik D. Woodland, Anthony Thompson, Amanda Lipford, Navneet Goyal, John C. Schexnaildre, Madhusoodanan Mottamal, Daniel K. Afosah, Rami A. Al-Horani
Publikováno v:
ACS Omega, Vol 9, Iss 9, Pp 10694-10708 (2024)
Externí odkaz:
https://doaj.org/article/6c2b504614794dc5bb393aa293435adf
Autor:
Daniel K. Afosah, Rawan M. Fayyad, Valerie R. Puliafico, Spencer Merrell, Eltice K. Langmia, Sophie R. Diagne, Rami A. Al-Horani, Umesh R. Desai
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 760 (2023)
Cathepsin G (CatG) is a pro-inflammatory neutrophil serine protease that is important for host defense, and has been implicated in several inflammatory disorders. Hence, inhibition of CatG holds much therapeutic potential; however, only a few inhibit
Externí odkaz:
https://doaj.org/article/1097e4fa5d0a43ee96427a13d0f7ae17
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 886 (2021)
The anticoagulant activity of lignosulfonic acid sodium (LSAS), a non-saccharide heparin mimetic, was investigated in this study. LSAS is a relatively safe industrial byproduct with similar polyanionic characteristics to that of heparin. Human plasma
Externí odkaz:
https://doaj.org/article/71f12971c6144374b71949918e37fdfc
Publikováno v:
Cardiovascular & Hematological Agents in Medicinal Chemistry. 21:108-119
Background: Human factor XIIa (FXIIa) is a plasma serine protease that plays a significant role in several physiological and pathological processes. Animal models have revealed an important contribution of FXIIa to thromboembolic diseases. Remarkably
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464011beae8374439682c9f9c7b21200
https://doi.org/10.2174/1871525721666221031141323
https://doi.org/10.2174/1871525721666221031141323
Autor:
Elsamani I. Abdelfadiel, Rama Gunta, Bharath Kumar Villuri, Daniel K. Afosah, Nehru Viji Sankaranarayanan, Umesh R. Desai
Publikováno v:
Journal of Medicinal Chemistry. 66:4503-4531
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c438a23de9919732885dcec7a9c50cc6
https://doi.org/10.1021/acs.jmedchem.3c00132
https://doi.org/10.1021/acs.jmedchem.3c00132
Autor:
Shravan Morla, Ongolu Ravikumar, Connor O’Hara, Rio Boothello, Alberto Vera, Elsamani I. Abdelfadiel, Rawan Fayyad, Daniel K. Afosah, Chetna Sharon, Leopoldo Fernandez, Syed Ammer Shah, Bhaumik B. Patel, Umesh R. Desai
Publikováno v:
Journal of Medicinal Chemistry. 66:1321-1338
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e61143d660717d1e22ab43b710273bd
https://doi.org/10.1021/acs.jmedchem.2c01511
https://doi.org/10.1021/acs.jmedchem.2c01511
Publikováno v:
Expert Opin Ther Pat
INTRODUCTION: Anticoagulation with no bleeding complications is the current objective of drug discovery programs in the area of treating and/or preventing thromboembolism. Despite the promises of therapeutics targeting factors XI(a) and XII(a), none
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d024a5e6fe50c769249e3b368df66903
https://doi.org/10.1080/13543776.2022.2026926
https://doi.org/10.1080/13543776.2022.2026926
Publikováno v:
RPS Pharmacy and Pharmacology Reports. 2
ObjectiveCathepsin G (CatG) is a cationic serine protease with wide substrate specificity. CatG is reported to play a role in several inflammatory pathologies. Thus, we aimed at identifying a potent and allosteric inhibitor of CatG to be used as a pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6564a420c7454ff0e5abdc03bacd984f
https://doi.org/10.1093/rpsppr/rqad001
https://doi.org/10.1093/rpsppr/rqad001
Publikováno v:
Carbohydrate Research. 529:108831
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcf5a19c3f6632e035d7f276509e6d65
https://doi.org/10.1016/j.carres.2023.108831
https://doi.org/10.1016/j.carres.2023.108831