Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Daniel Kümmel"'
Autor:
Nikolay T. Garabedian, Paul J. Schreiber, Nico Brandt, Philipp Zschumme, Ines L. Blatter, Antje Dollmann, Christian Haug, Daniel Kümmel, Yulong Li, Franziska Meyer, Carina E. Morstein, Julia S. Rau, Manfred Weber, Johannes Schneider, Peter Gumbsch, Michael Selzer, Christian Greiner
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-11 (2022)
Abstract Solutions for the generation of FAIR (Findable, Accessible, Interoperable, and Reusable) data and metadata in experimental tribology are currently lacking. Nonetheless, FAIR data production is a promising path for implementing scalable data
Externí odkaz:
https://doaj.org/article/3456662c3cb54006a016bb2daca2ff28
Autor:
Dmitry Shvarev, Jannis Schoppe, Caroline König, Angela Perz, Nadia Füllbrunn, Stephan Kiontke, Lars Langemeyer, Dovile Januliene, Kilian Schnelle, Daniel Kümmel, Florian Fröhlich, Arne Moeller, Christian Ungermann
Publikováno v:
eLife, Vol 11 (2022)
Lysosomes are essential for cellular recycling, nutrient signaling, autophagy, and pathogenic bacteria and viruses invasion. Lysosomal fusion is fundamental to cell survival and requires HOPS, a conserved heterohexameric tethering complex. On the mem
Externí odkaz:
https://doaj.org/article/def295925ee6473dbd2d3883d11521f1
Autor:
Lars Langemeyer, Ann-Christin Borchers, Eric Herrmann, Nadia Füllbrunn, Yaping Han, Angela Perz, Kathrin Auffarth, Daniel Kümmel, Christian Ungermann
Publikováno v:
eLife, Vol 9 (2020)
Endosomes and lysosomes harbor Rab5 and Rab7 on their surface as key proteins involved in their identity, biogenesis, and fusion. Rab activation requires a guanine nucleotide exchange factor (GEF), which is Mon1-Ccz1 for Rab7. During endosome maturat
Externí odkaz:
https://doaj.org/article/565a34edef7e4052a6e9c8fc62e3ccc1
Autor:
Stephan Kiontke, Lars Langemeyer, Anne Kuhlee, Saskia Schuback, Stefan Raunser, Christian Ungermann, Daniel Kümmel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The Mon1-Ccz1 (MC1) complex is a Rab guanine nucleotide exchange factor (RabGEF) for Ypt7/Rab7 important for endosomal maturation. Here the authors present the biochemical and structural characterization of MC1, elucidating its catalytic mechanism an
Externí odkaz:
https://doaj.org/article/3db419966f5f44748a3a872c39345aec
Publikováno v:
eLife, Vol 7 (2018)
During autophagy, a newly formed double membrane surrounds its cargo to generate the so-called autophagosome, which then fuses with a lysosome after closure. Previous work implicated that endosomal Rab7/Ypt7 associates to autophagosomes prior to thei
Externí odkaz:
https://doaj.org/article/0d4fab6aa5f04ea5b26dba95d296fd62
Autor:
Roland Hellinger, Kathrin Thell, Mina Vasileva, Taj Muhammad, Sunithi Gunasekera, Daniel Kümmel, Ulf Göransson, Christian W. Becker, Christian W. Gruber
Publikováno v:
Frontiers in Chemistry, Vol 5 (2017)
Target deconvolution is one of the most challenging tasks in drug discovery, but a key step in drug development. In contrast to small molecules, there is a lack of validated and robust methodologies for target elucidation of peptides. In particular,
Externí odkaz:
https://doaj.org/article/57d35bad86d74a89b4e3a9d1ca88333b
Autor:
Shyam S Krishnakumar, Feng Li, Jeff Coleman, Curtis M Schauder, Daniel Kümmel, Frédéric Pincet, James E Rothman, Karin M Reinisch
Publikováno v:
eLife, Vol 6 (2017)
Externí odkaz:
https://doaj.org/article/c2bf1089573e42d9b679a57e16326f11
Autor:
Shyam S Krishnakumar, Feng Li, Jeff Coleman, Curtis M Schauder, Daniel Kümmel, Frederic Pincet, James E Rothman, Karin M Reinisch
Publikováno v:
eLife, Vol 4 (2015)
We have previously proposed that complexin cross-links multiple pre-fusion SNARE complexes via a trans interaction to function as a clamp on SNARE-mediated neurotransmitter release. A recent NMR study was unable to detect the trans clamping interacti
Externí odkaz:
https://doaj.org/article/263cb1aba1aa44c5a1702481fe6c6281
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4656 (2009)
The golgin family gives identity and structure to the Golgi apparatus and is part of a complex protein network at the Golgi membrane. The golgin p115 is targeted by the GTPase Rab1a, contains a large globular head region and a long region of coiled-c
Externí odkaz:
https://doaj.org/article/1e2f35b261774061b9dfd2a53e4c25e3
Autor:
Tim Pasch, Alexander Schröder, Sabrina Kattelmann, Miriam Eisenstein, Shmuel Pietrokovski, Daniel Kümmel, Henning D. Mootz
Publikováno v:
Chemical Science. 14:5204-5213
Cysteine-less split inteins are very useful, but rare tools for protein engineering. Investigation of the novel PolB16 intein revealed a previously overlooked histidine as a conserved part for the serine-dependent mechanism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e8abab9ba05a1f119a45604f6a44055
https://doi.org/10.1039/d3sc01200j
https://doi.org/10.1039/d3sc01200j