Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Daniel Jiménez-Blasco"'
Autor:
Ana Paredes, Raquel Justo-Méndez, Daniel Jiménez-Blasco, Vanessa Núñez, Irene Calero, María Villalba-Orero, Andrea Alegre-Martí, Thierry Fischer, Ana Gradillas, Viviane Aparecida Rodrigues Sant’Anna, Felipe Were, Zhiqiang Huang, Pablo Hernansanz-Agustín, Carmen Contreras, Fernando Martínez, Emilio Camafeita, Jesús Vázquez, Jesús Ruiz-Cabello, Estela Area-Gómez, Fátima Sánchez-Cabo, Eckardt Treuter, Juan Pedro Bolaños, Eva Estébanez-Perpiñá, Francisco Javier Rupérez, Coral Barbas, José Antonio Enríquez, Mercedes Ricote
Publikováno v:
Nature.
Birth presents a metabolic challenge to cardiomyocytes as they reshape fuel preference from glucose to fatty acids for postnatal energy production1,2. This adaptation is triggered in part by post-partum environmental changes3, but the molecules orche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be78cc3825500859c8e20538935435db
https://doi.org/10.1038/s41586-023-06068-7
https://doi.org/10.1038/s41586-023-06068-7
Autor:
Isabel Mulet, Carmen Grueso-Cortina, Mireia Cortés-Cano, Daniela Gerovska, Guangming Wu, Stefania Alexandra Iakab, Daniel Jimenez-Blasco, Andrea Curtabbi, Pablo Hernansanz-Agustín, Harmony Ketchum, Israel Manjarrés-Raza, F. Thomas Wunderlich, Juan Pedro Bolaños, Meelad M. Dawlaty, Carsten Hopf, José Antonio Enríquez, Marcos J. Araúzo-Bravo, Natalia Tapia
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract TET-family members play a critical role in cell fate commitment. Indeed, TET3 is essential to postnatal development due to yet unknown reasons. To define TET3 function in cell differentiation, we have profiled the intestinal epithelium at si
Externí odkaz:
https://doaj.org/article/bc646249624b4d23967654764f32eee6
Publikováno v:
Neurochemical research. 46(1)
Metabolism and redox signalling share critical nodes in the nervous system. In the last years, a series of major findings have challenged the current vision on how neural reactive oxygen species (ROS) are produced and handled in the nervous system. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f702af3730ea13eb205161918093b18f
https://pubmed.ncbi.nlm.nih.gov/31989468
https://pubmed.ncbi.nlm.nih.gov/31989468
Autor:
Daniel Jiménez Blasco
Publikováno v:
GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname
instname
[ES]La neurotransmisión glutamatérgica inevitablemente conlleva a la formación de especies reactivas de oxígeno (ROS) que puede desencadenar en daño oxidativo y conducir eventualmente a la neurodegeneración. En este trabajo se describe que la a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18562685e959ff313a5008efaa86ece
https://doi.org/10.14201/gredos.125471
https://doi.org/10.14201/gredos.125471
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106199- (2023)
Mitochondrial reactive oxygen species (mROS) have been generally considered harmful byproducts wanted to clear when elevated to avoid brain damage. However, the abundance of mROS in astrocytes is very high -about one order of magnitude above that in
Externí odkaz:
https://doaj.org/article/7979a4cd33634a7493036d1f1d216732
Autor:
Irene Lopez-Fabuel, Marina Garcia-Macia, Costantina Buondelmonte, Olga Burmistrova, Nicolo Bonora, Paula Alonso-Batan, Brenda Morant-Ferrando, Carlos Vicente-Gutierrez, Daniel Jimenez-Blasco, Ruben Quintana-Cabrera, Emilio Fernandez, Jordi Llop, Pedro Ramos-Cabrer, Aseel Sharaireh, Marta Guevara-Ferrer, Lorna Fitzpatrick, Christopher D. Thompton, Tristan R. McKay, Stephan Storch, Diego L. Medina, Sara E. Mole, Peter O. Fedichev, Angeles Almeida, Juan P. Bolaños
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
CLN7 neuronal ceroid lipofuscinosis is an inherited lysosomal storage disease typically with childhood onset of neurodegenerative symptoms. Here the authors report that in a mouse model of CLN7 disease neuronal reactive oxygen species and the activit
Externí odkaz:
https://doaj.org/article/3a651b3190b84e729467d309cc661713
Autor:
Ayelén M Santamans, Valle Montalvo-Romeral, Alfonso Mora, Juan Antonio Lopez, Francisco González-Romero, Daniel Jimenez-Blasco, Elena Rodríguez, Aránzazu Pintor-Chocano, Cristina Casanueva-Benítez, Rebeca Acín-Pérez, Luis Leiva-Vega, Jordi Duran, Joan J Guinovart, Jesús Jiménez-Borreguero, José Antonio Enríquez, María Villlalba-Orero, Juan P Bolaños, Patricia Aspichueta, Jesús Vázquez, Bárbara González-Terán, Guadalupe Sabio
Publikováno v:
PLoS Biology, Vol 19, Iss 11, p e3001447 (2021)
During the first weeks of postnatal heart development, cardiomyocytes undergo a major adaptive metabolic shift from glycolytic energy production to fatty acid oxidation. This metabolic change is contemporaneous to the up-regulation and activation of
Externí odkaz:
https://doaj.org/article/c36e9e81543246be91c8817f25d367e5
Autor:
Olga Burmistrova, Ana Olias-Arjona, Rebeca Lapresa, Daniel Jimenez-Blasco, Tatiana Eremeeva, Dmitry Shishov, Sergei Romanov, Kristina Zakurdaeva, Angeles Almeida, Peter O. Fedichev, Juan P. Bolaños
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract The glycolytic rate in neurons is low in order to allow glucose to be metabolized through the pentose-phosphate pathway (PPP), which regenerates NADPH to preserve the glutathione redox status and survival. This is controlled by 6-phosphofruc
Externí odkaz:
https://doaj.org/article/883ca8c766f94de9a52ed1902af7bd39
Autor:
Carlos Vicente-Gutierrez, Nicolo Bonora, Daniel Jimenez-Blasco, Irene Lopez-Fabuel, Georgina Bates, Michael P. Murphy, Angeles Almeida, Juan P. Bolaños
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101917- (2021)
Cells naturally produce mitochondrial reactive oxygen species (mROS), but the in vivo pathophysiological significance has long remained controversial. Within the brain, astrocyte-derived mROS physiologically regulate behaviour and are produced at one
Externí odkaz:
https://doaj.org/article/9462a7ade17b47cc88f555f221fcda57