Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Daniel Jiménez-Blasco"'
Autor:
Ana Paredes, Raquel Justo-Méndez, Daniel Jiménez-Blasco, Vanessa Núñez, Irene Calero, María Villalba-Orero, Andrea Alegre-Martí, Thierry Fischer, Ana Gradillas, Viviane Aparecida Rodrigues Sant’Anna, Felipe Were, Zhiqiang Huang, Pablo Hernansanz-Agustín, Carmen Contreras, Fernando Martínez, Emilio Camafeita, Jesús Vázquez, Jesús Ruiz-Cabello, Estela Area-Gómez, Fátima Sánchez-Cabo, Eckardt Treuter, Juan Pedro Bolaños, Eva Estébanez-Perpiñá, Francisco Javier Rupérez, Coral Barbas, José Antonio Enríquez, Mercedes Ricote
Publikováno v:
Nature.
Birth presents a metabolic challenge to cardiomyocytes as they reshape fuel preference from glucose to fatty acids for postnatal energy production1,2. This adaptation is triggered in part by post-partum environmental changes3, but the molecules orche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be78cc3825500859c8e20538935435db
https://doi.org/10.1038/s41586-023-06068-7
https://doi.org/10.1038/s41586-023-06068-7
Publikováno v:
Neurochemical research. 46(1)
Metabolism and redox signalling share critical nodes in the nervous system. In the last years, a series of major findings have challenged the current vision on how neural reactive oxygen species (ROS) are produced and handled in the nervous system. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f702af3730ea13eb205161918093b18f
https://pubmed.ncbi.nlm.nih.gov/31989468
https://pubmed.ncbi.nlm.nih.gov/31989468
Autor:
Daniel Jiménez Blasco
Publikováno v:
GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname
instname
[ES]La neurotransmisión glutamatérgica inevitablemente conlleva a la formación de especies reactivas de oxígeno (ROS) que puede desencadenar en daño oxidativo y conducir eventualmente a la neurodegeneración. En este trabajo se describe que la a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18562685e959ff313a5008efaa86ece
https://doi.org/10.14201/gredos.125471
https://doi.org/10.14201/gredos.125471
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106199- (2023)
Mitochondrial reactive oxygen species (mROS) have been generally considered harmful byproducts wanted to clear when elevated to avoid brain damage. However, the abundance of mROS in astrocytes is very high -about one order of magnitude above that in
Externí odkaz:
https://doaj.org/article/7979a4cd33634a7493036d1f1d216732
Autor:
Irene Lopez-Fabuel, Marina Garcia-Macia, Costantina Buondelmonte, Olga Burmistrova, Nicolo Bonora, Paula Alonso-Batan, Brenda Morant-Ferrando, Carlos Vicente-Gutierrez, Daniel Jimenez-Blasco, Ruben Quintana-Cabrera, Emilio Fernandez, Jordi Llop, Pedro Ramos-Cabrer, Aseel Sharaireh, Marta Guevara-Ferrer, Lorna Fitzpatrick, Christopher D. Thompton, Tristan R. McKay, Stephan Storch, Diego L. Medina, Sara E. Mole, Peter O. Fedichev, Angeles Almeida, Juan P. Bolaños
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
CLN7 neuronal ceroid lipofuscinosis is an inherited lysosomal storage disease typically with childhood onset of neurodegenerative symptoms. Here the authors report that in a mouse model of CLN7 disease neuronal reactive oxygen species and the activit
Externí odkaz:
https://doaj.org/article/3a651b3190b84e729467d309cc661713
Autor:
Ayelén M Santamans, Valle Montalvo-Romeral, Alfonso Mora, Juan Antonio Lopez, Francisco González-Romero, Daniel Jimenez-Blasco, Elena Rodríguez, Aránzazu Pintor-Chocano, Cristina Casanueva-Benítez, Rebeca Acín-Pérez, Luis Leiva-Vega, Jordi Duran, Joan J Guinovart, Jesús Jiménez-Borreguero, José Antonio Enríquez, María Villlalba-Orero, Juan P Bolaños, Patricia Aspichueta, Jesús Vázquez, Bárbara González-Terán, Guadalupe Sabio
Publikováno v:
PLoS Biology, Vol 19, Iss 11, p e3001447 (2021)
During the first weeks of postnatal heart development, cardiomyocytes undergo a major adaptive metabolic shift from glycolytic energy production to fatty acid oxidation. This metabolic change is contemporaneous to the up-regulation and activation of
Externí odkaz:
https://doaj.org/article/c36e9e81543246be91c8817f25d367e5
Autor:
Olga Burmistrova, Ana Olias-Arjona, Rebeca Lapresa, Daniel Jimenez-Blasco, Tatiana Eremeeva, Dmitry Shishov, Sergei Romanov, Kristina Zakurdaeva, Angeles Almeida, Peter O. Fedichev, Juan P. Bolaños
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract The glycolytic rate in neurons is low in order to allow glucose to be metabolized through the pentose-phosphate pathway (PPP), which regenerates NADPH to preserve the glutathione redox status and survival. This is controlled by 6-phosphofruc
Externí odkaz:
https://doaj.org/article/883ca8c766f94de9a52ed1902af7bd39
Autor:
Carlos Vicente-Gutierrez, Nicolo Bonora, Daniel Jimenez-Blasco, Irene Lopez-Fabuel, Georgina Bates, Michael P. Murphy, Angeles Almeida, Juan P. Bolaños
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101917- (2021)
Cells naturally produce mitochondrial reactive oxygen species (mROS), but the in vivo pathophysiological significance has long remained controversial. Within the brain, astrocyte-derived mROS physiologically regulate behaviour and are produced at one
Externí odkaz:
https://doaj.org/article/9462a7ade17b47cc88f555f221fcda57