Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Daniel James Ford"'
Autor:
Adnan Khan, Farnaz Fallah-Arani, Bart Vanderhoydonck, Judi Charlotte Neuss, Sarah Malcolm, Alfred Lammens, Richard J. Franklin, Lindsay K. Shuttleworth, Qiuya Huang, Jamie Henshall, Daniel James Ford, Mi-Yeon Jang, Shengqiao Li, Helen Tracey Horsley, Daniel Christopher Brookings, Mark Waer, Rodger A. Allen, Payne Andrew Charles, Yuan Lin, Eleanor Ward, Tom Ceska, Piet Herdewijn, Mark Jairaj, James Thomas Reuberson, Stefan Steinbacher, Mark Daniel Calmiano, Carl Brendan Doyle, Ling-Jie Gao, William R. Pitt, Jean Herman, Martin Augustin, Thierry Louat, Anant Ramrao Ghawalkar
Publikováno v:
Journal of medicinal chemistry. 61(15)
The primary target of a novel series of immunosuppressive 7-piperazin-1-ylthiazolo[5,4- d]pyrimidin-5-amines was identified as the lipid kinase, PI4KIIIβ. Evaluation of the series highlighted their poor solubility and unwanted off-target activities.
Autor:
Matthew P. Crump, Harry Mackenzie, Christine E. Prosser, Adam Hold, John Crosby, Daniel James Ford, John Robert Porter, Ian Whitcombe, Richard J. K. Taylor, Rachel A. Garlish, Hannah J. Maple
Publikováno v:
Analytical Chemistry. 85:5958-5964
Atropisomerism of pharmaceutical compounds is a challenging area for drug discovery programs (Angew. Chem., Int. Ed. 2009, 48, 6398-6401). Strategies for dealing with these compounds include raising the energy barrier to atropisomerization in order t
Autor:
Payne Andrew H, Adam Hold, Graham Trevitt, Jeremy Martin Davis, Chloe Edwards, Clare Watkins, Brian Hutchinson, Daniel James Ford, Rachel A. Garlish, John Robert Porter, James D. Turner, Ian Whitcombe, Colin Stubberfield, Ben de Candole
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1767-1772
The separation of atropisomeric conformers of 1,2,3,4-tetrahydroisoquinoline amide Bcl-2 ligands allowed the identification of the bioactive conformer which was subsequently confirmed by X-ray crystallography.