Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Daniel Jacko"'
1
Akademický článek
Acute resistance exercise and training reduce desmin phosphorylation at serine 31 in human skeletal muscle, making the protein less prone to cleavage
Autor: Daniel Jacko, Kirill Schaaf, Thorben Aussieker, Lukas Masur, Jonas Zacher, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Desmin intermediate filaments play a crucial role in stress transmission and mechano-protection. The loss of its integrity triggers myofibril breakdown and muscle atrophy for which desmin phosphorylation (pDes) is a priming factor. We invest
Externí odkaz: https://doaj.org/article/a0f26e8a77b749ea947bbed1382c151c
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2
Akademický článek
Increased resting lactate levels and reduced carbohydrate intake cause νLa.max underestimation by reducing net lactate accumulation—A pilot study in young adults
Autor: Alexander Pohl, Frederik Schünemann, Kirill Schaaf, Woo‐Hwi Yang, Hermann Heck, Oliver Heine, Daniel Jacko, Sebastian Gehlert
Publikováno v: Physiological Reports, Vol 12, Iss 16, Pp n/a-n/a (2024)
Abstract Modulation of testing conditions such as resting lactate (Larest) levels or carbohydrate intake may affect the calculation of the maximal glycolytic rate (νLa.max). To evaluate the impact of elevated Larest as well as reduced and increased
Externí odkaz: https://doaj.org/article/4b1f94ad742c4ab1ab6cacb97e6de9bb
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3
Akademický článek
Resistance training does not increase myocellular garbage dumps: A pilot study on lipofuscin in skeletal muscle fibers of resistance trained young men
Autor: Daniel Jacko, Lukas Masur, Kirill Schaaf, Jonas Zacher, Käthe Bersiner, Markus deMarées, Wilhelm Bloch, Sebastian Gehlert
Publikováno v: Physiological Reports, Vol 12, Iss 3, Pp n/a-n/a (2024)
Abstract Lipofuscin (LF) is an intracellular aggregate associated with proteostatic impairments, especially prevalent in nondividing skeletal muscle fibers. Reactive oxygen species (ROS) drive LF‐formation. Resistance training (RT) improves muscle
Externí odkaz: https://doaj.org/article/9de2453f360d4e1a83e0ee1c69311207
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4
Akademický článek
Effects of Acute and Chronic Resistance Exercise on the Skeletal Muscle Metabolome
Autor: Sebastian Gehlert, Patrick Weinisch, Werner Römisch-Margl, Richard T. Jaspers, Anna Artati, Jerzy Adamski, Kenneth A. Dyar, Thorben Aussieker, Daniel Jacko, Wilhelm Bloch, Henning Wackerhage, Gabi Kastenmüller
Publikováno v: Metabolites, Vol 12, Iss 5, p 445 (2022)
Resistance training promotes metabolic health and stimulates muscle hypertrophy, but the precise routes by which resistance exercise (RE) conveys these health benefits are largely unknown. Aim: To investigate how acute RE affects human skeletal muscl
Externí odkaz: https://doaj.org/article/6ca5fe2ae25a415bb8e33db8a298acd4
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5
Akademický článek
Resistance exercise-induced muscle fatigue is not accompanied by increased phosphorylation of ryanodine receptor 1 at serine 2843.
Autor: Daniel Jacko, Käthe Bersiner, Gerrit Friederichs, Patrick Ritter, Linnea Nirenberg, Jan Eisenbraun, Markus de Marées, Wilhelm Bloch, Sebastian Gehlert
Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0199307 (2018)
Skeletal muscle fatigue has been shown to be associated with hyperphosphorylation of the ryanodine receptor 1 at serine 2843 (pRyR1Ser2843), due to chronic overloading exercise. We investigated whether pRyR1Ser2843, is a mechanism relevant for muscle
Externí odkaz: https://doaj.org/article/be4bb5cef66a42fda75ec4ef1170fc45
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6
Akademický článek
p38 MAPK activation and H3K4 trimethylation is decreased by lactate in vitro and high intensity resistance training in human skeletal muscle.
Autor: Lena Willkomm, Sebastian Gehlert, Daniel Jacko, Thorsten Schiffer, Wilhelm Bloch
Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0176609 (2017)
Exercise induces adaptation of skeletal muscle by acutely modulating intracellular signaling, gene expression, protein turnover and myogenic activation of skeletal muscle stem cells (Satellite cells, SCs). Lactate (La)-induced metabolic stimulation a
Externí odkaz: https://doaj.org/article/f9aed6dd9c534500865f117153111d1c
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7
Repeated and Interrupted Resistance Exercise Induces the Desensitization and Re-Sensitization of mTOR-Related Signaling in Human Skeletal Muscle Fibers
Autor: Daniel Jacko, Kirill Schaaf, Lukas Masur, Hannes Windoffer, Thorben Aussieker, Thorsten Schiffer, Jonas Zacher, Wilhelm Bloch, Sebastian Gehlert
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5431
The acute resistance exercise (RE)-induced phosphorylation of mTOR-related signaling proteins in skeletal muscle can be blunted after repeated RE. The time frame in which the phosphorylation (p) of mTORS2448, p70S6kT421/S424, and rpS6S235/236 will be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0e055c38642e8984d0ba4dc09b43ec
https://pubmed.ncbi.nlm.nih.gov/35628242
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8
PKM2 determines myofiber hypertrophy in vitro and increases in response to resistance exercise in human skeletal muscle
Autor: Gerard M.J. de Wit, Richard T. Jaspers, Daniel Jacko, Henning Wackerhage, Lian E.M. Stadhouders, Ilse S.P. Vogel, Martin Schönfelder, Thorben Aussieker, Carla Offringa, Sebastian Gehlert, Sander A.J. Verbrugge
Publikováno v: Verbrugge, S A J, Gehlert, S, Stadhouders, L E M, Jacko, D, Aussieker, T, de Wit, G M J, Vogel, I S P, Offringa, C, Schönfelder, M, Jaspers, R T & Wackerhage, H 2020, ' PKM2 determines myofiber hypertrophy in vitro and increases in response to resistance exercise in human skeletal muscle ', International Journal of Molecular Sciences, vol. 21, no. 19, 7062, pp. 1-15 . https://doi.org/10.3390/ijms21197062
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 21(19):7062, 1-15. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 21, Iss 7062, p 7062 (2020)
Volume 21
Issue 19
Nearly 100 years ago, Otto Warburg investigated the metabolism of growing tissues and discovered that tumors reprogram their metabolism. It is poorly understood whether and how hypertrophying muscle, another growing tissue, reprograms its metabolism
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e1579a4ab01f7b42658b17cb309e58
https://doi.org/10.3390/ijms21197062
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9
Coordinated alpha-crystallin B phosphorylation and desmin expression indicate adaptation and deadaptation to resistance exercise-induced loading in human skeletal muscle
Autor: Sebastian Gehlert, Oliver Schulz, Willhelm Bloch, Fabian Spahiu, Jörg Höhfeld, Daniel Jacko, Käthe Bersiner, Axel Przyklenk
Publikováno v: American Journal of Physiology-Cell Physiology. 319:C300-C312
Skeletal muscle is a target of contraction-induced loading (CiL), leading to protein unfolding or cellular perturbations, respectively. While cytoskeletal desmin is responsible for ongoing structural stabilization, in the immediate response to CiL, a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629aca3d8a086f947b9547021dcf492d
https://doi.org/10.1152/ajpcell.00087.2020
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