Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Daniel J. Whitcomb"'
Autor:
Seung Chan Kim, Scott J. Mitchell, Seema Qamar, Daniel J. Whitcomb, Marc-David Ruepp, Peter St George-Hyslop, Kwangwook Cho
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-15 (2023)
Abstract The hypomethylation of fused in sarcoma (FUS) in frontotemporal lobar degeneration promotes the formation of irreversible condensates of FUS. However, the mechanisms by which these hypomethylated FUS condensates cause neuronal dysfunction ar
Externí odkaz:
https://doaj.org/article/f1d094e7bd984d60b4f09d9494f5578d
Autor:
Benjamin Clennell, Tom G.J. Steward, Kaliya Hanman, Tom Needham, Janette Benachour, Mark Jepson, Meg Elley, Nathan Halford, Kate Heesom, Eunju Shin, Elek Molnár, Bruce W. Drinkwater, Daniel J. Whitcomb
Publikováno v:
Brain Stimulation, Vol 16, Iss 2, Pp 540-552 (2023)
Background: Focused ultrasound stimulation (FUS) has the potential to provide non-invasive neuromodulation of deep brain regions with unparalleled spatial precision. However, the cellular and molecular consequences of ultrasound stimulation on neuron
Externí odkaz:
https://doaj.org/article/6cddc2561d5d435595f4962a56b3ee87
Autor:
Bret Sanders, Daniel D’Andrea, Mark O. Collins, Elliott Rees, Tom G. J. Steward, Ying Zhu, Gareth Chapman, Sophie E. Legge, Antonio F. Pardiñas, Adrian J. Harwood, William P. Gray, Michael C. O’Donovan, Michael J. Owen, Adam C. Errington, Derek J. Blake, Daniel J. Whitcomb, Andrew J. Pocklington, Eunju Shin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Coordinated programs of gene expression drive brain development. Here, the authors use human embryonic stem cells and foetal cortical tissue as well as available GWAS statistics and analysis of genetic variants associated with neuropsychiatric disord
Externí odkaz:
https://doaj.org/article/42f6d2253f3b4cb0a163dcbb417d1ba0
Autor:
Benjamin Clennell, Tom G.J. Steward, Meg Elley, Eunju Shin, Miles Weston, Bruce W. Drinkwater, Daniel J. Whitcomb
Publikováno v:
Brain Stimulation, Vol 14, Iss 2, Pp 217-225 (2021)
Background: Transcranial ultrasound stimulation can acutely modulate brain activity, but the lasting effects on neurons are unknown. Objective: To assess the excitability profile of neurons in the hours following transient ultrasound stimulation. Met
Externí odkaz:
https://doaj.org/article/925b7dc86b6049a29f190a6205dde7ff
Autor:
Keng Siang Lee, Benjamin Clennell, Tom G. J. Steward, Andriana Gialeli, Oscar Cordero-Llana, Daniel J. Whitcomb
Publikováno v:
Brain Sciences, Vol 12, Iss 2, p 289 (2022)
Non-invasive focused ultrasound stimulation (FUS) is a non-ionising neuromodulatory technique that employs acoustic energy to acutely and reversibly modulate brain activity of deep-brain structures. It is currently being investigated as a potential n
Externí odkaz:
https://doaj.org/article/c8c4e6a9765846259a5d4a46b2c057fe
Publikováno v:
Molecular Brain, Vol 10, Iss 1, Pp 1-10 (2017)
Abstract Alzheimer’s disease (AD) is defined by the excessive accumulation of toxic peptides, such as beta amyloid (Aβ) plaques and intracellular neurofibrillary tangles (NFT). The risk factors associated with AD include genetic mutations, aging,
Externí odkaz:
https://doaj.org/article/884d3a2492e74000bce5f64030b2ed44
Publikováno v:
Molecular Brain, Vol 10, Iss 1, Pp 1-1 (2017)
Correction to: Molecular Brain (2017) 10:35 DOI: 10.1186/s13041-017-0315-x In the original version of this article [1], published on 1 August 2017, Fig. 3 contains a typo. In this Correction the incorrect and correct version of Fig. 3 are shown. - Fi
Externí odkaz:
https://doaj.org/article/a14de8ce5d0f41f9ae909043901c3582
Autor:
Lucy A Crompton, Sarah F McComish, Tom G J Steward, Daniel J Whitcomb, Jon D Lane, Maeve A Caldwell
Publikováno v:
Brain Communications. 5
This scientific commentary refers to ‘Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles’, by Clarke et al. (https://doi.org/10.1093/brain/awaa258) in Brain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24786d7d03c0001bda4e25bcf9de9153
https://doi.org/10.1093/braincomms/fcad114
https://doi.org/10.1093/braincomms/fcad114
Autor:
Jee-Hyun Yi, Chinedu Udeh-Momoh, Stafford L. Lightman, Eleanor Waite, Becky L. Conway-Campbell, Daniel J. Whitcomb, Thomas M. Piers, Garry Whitehead, Kwangwook Cho
Experience-dependent synaptic plasticity is important for learning and memory and regulated by the functions of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors. Glucocorticoids have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78e2acd10599a559494c86d03ac38521
https://doi.org/10.21203/rs.3.rs-923210/v1
https://doi.org/10.21203/rs.3.rs-923210/v1
Autor:
Derek J. Blake, Bret Sanders, Eunju Shin, Daniel J. Whitcomb, Daniel D’Andrea, Antonio F. Pardiñas, Michael Conlon O'Donovan, Mark O. Collins, Andrew Pocklington, Adrian J. Harwood, Ying Zhu, Michael John Owen, Elliott Rees, Adam C. Errington, William P. Gray, Gareth Chapman, Sophie E. Legge, Tom G. J. Steward
Publikováno v:
medRxiv
Brain development requires a complex choreography of cell proliferation, specialisation, migration and network formation, guided by the activation and repression of gene expression programs. It remains unclear how this process is disrupted in neurops
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff70010307689e36d2abb500c65f305d
https://eprints.keele.ac.uk/10530/1/2020.01.10.898676v2.full.pdf
https://eprints.keele.ac.uk/10530/1/2020.01.10.898676v2.full.pdf