Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Daniel J. Waldon"'
Publikováno v:
Drug Metabolism and Disposition. 36:1740-1744
Diclofenac (2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid), a nonsteroidal antiinflammatory drug, undergoes bioactivation by cytochrome P450 oxidation to chemically reactive metabolites that are capable of reacting with endogenous nucleophiles s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5553b1f110350267895e46ebf3cbf1d
https://doi.org/10.1124/dmd.108.021287
https://doi.org/10.1124/dmd.108.021287
Autor:
Daniel J. Waldon, P E Sanders, Fengmei Hua, Joseph A. Ware, Charles G. Knutson, Mark P. Grillo
Publikováno v:
Drug Metabolism and Disposition. 31:1327-1336
Diclofenac, a nonsteroidal anti-inflammatory drug, is metabolized to a reactive acyl glucuronide that has been proposed to mediate toxic adverse drug reactions associated with its use. In the present study, we examined the ability of diclofenac acyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f148a877c684b14d8cc586190f1c8b56
https://doi.org/10.1124/dmd.31.11.1327
https://doi.org/10.1124/dmd.31.11.1327
Autor:
William G. McDonald, Alexander S. Mankin, Dean L. Shinabarger, Liqun Xiong, Eric T. Lund, Jerry R. Colca, James D. Pearson, Lonnie D. Adams, John E. Mott, Eric T. Cecil, Gregory S. Cavey, Daniel J. Waldon, W. Rodney Mathews, Lisa Marie Thomasco, Jeffrey H. Bock, Robert C. Gadwood
Publikováno v:
Journal of Biological Chemistry. 278:21972-21979
Oxazolidinone antibiotics, an important new class of synthetic antibacterials, inhibit protein synthesis by interfering with ribosomal function. The exact site and mechanism of oxazolidinone action has not been elucidated. Although genetic data point
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16377689cfa93ac00956916876aa9e75
https://doi.org/10.1074/jbc.m302109200
https://doi.org/10.1074/jbc.m302109200
Publikováno v:
Chirality. 11:731-739
PNU-106893, N-{3-[1-(4-hydroxy-2-oxo-6-phenyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-2,2-dimethylpropyl]phenyl}-1-methyl-1H-imidazole-4-sulfonamide, is a selective HIV aspartyl protease inhibitor under evaluation as a potential oral treatment of acquire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6afae9890fe0b5717495a2dc82676be
https://doi.org/10.1002/(sici)1520-636x(1999)11:9<731::aid-chir9>3.0.co
https://doi.org/10.1002/(sici)1520-636x(1999)11:9<731::aid-chir9>3.0.co
Publikováno v:
Rapid communications in mass spectrometry : RCM. 24(16)
A new method for tissue imaging using desorption electrospray ionization (DESI) mass spectrometry is described. The technique utilizes a DESI source with a heated nebulizing gas and high-resolution accurate mass data acquired with an LTQ-Orbitrap mas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9ea8b7545f210ecfe48af5b2153fca0
https://pubmed.ncbi.nlm.nih.gov/20635324
https://pubmed.ncbi.nlm.nih.gov/20635324
Autor:
Kevin J Stefanski, Allen E. Buhl, Heinrich J. Schostarez, Bharat V. Kamdar, Marshall N. Brunden, Lisa Marie Thomasco, Garland A. Johnson, Kathy L. Shull, Daniel J. Waldon, Randall G. Stehle, A. R. Diani, Michael J. Mulholland, Theresa M. Schwartz, Steven J. Conrad, Robert C. Gadwood, Marc F. Kubicek
Publikováno v:
Journal of Investigative Dermatology. 98:315-319
The opening of intracellular potassium channels has been suggested as a mechanism regulating hair growth. Enhancing the flux of potassium ions is a mechanism shared by several structurally diverse antihypertensive agents including minoxidil sulfate (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c37d9c08572de8fad1039b8845b74a
https://doi.org/10.1111/1523-1747.ep12499788
https://doi.org/10.1111/1523-1747.ep12499788
Autor:
Donald K. MacCallum, Daniel J. Waldon, Garland A. Johnson, Karen A. Knight, Thomas T. Kawabe, Allen E. Buhl
Publikováno v:
Skin Pharmacology and Physiology. 5:114-123
To identify minoxidil target cells in hair follicles we followed the uptake of radiolabeled drug in mouse vibrissae follicles both in vitro and in vivo. Autoradiography showed that both 3H-minoxidil and 3H-minoxidil sulfate accumulated in the differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64704e26f69fab061c98212907034490
https://doi.org/10.1159/000211028
https://doi.org/10.1159/000211028
Autor:
Vince Groppi, Gabriel Vogeli, Daniel J. Waldon, Thomas J. Rea, Paula Andrus, Thomas E. Wagner, Allen E. Buhl, Alistair R. McNab, Thomas K. Kawabe
Publikováno v:
Proceedings of the National Academy of Sciences. 87:6848-6852
We have generated a transgenic mouse line by microinjection of a chimeric DNA fragment (KER-CAT) containing a hair-specific, murine ultra-high-sulfur keratin promoter (KER) fused to the coding region of the bacterial chloramphenicol acetyltransferase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b90d3bcf7d00c3db618a61acaac38bc
https://doi.org/10.1073/pnas.87.17.6848
https://doi.org/10.1073/pnas.87.17.6848
Autor:
June M. Lull, Daniel J. Waldon, W. Rodney Mathews, Joseph W. Leone, William G. McDonald, Carol A. Bannow, Eric T. Lund, Jerry R. Colca
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 286(2)
Thiazolidinediones address underlying causes of type 2 diabetes, although their mechanism of action is not clearly understood. The compounds are thought to function as direct activators of the nuclear receptor PPARγ (peroxisome proliferator-activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9c2250527805b800351aa8f695aa05
https://pubmed.ncbi.nlm.nih.gov/14570702
https://pubmed.ncbi.nlm.nih.gov/14570702
Publikováno v:
The Journal of investigative dermatology. 101
The opening of intracellular potassium channels is a common mechanism of action for a set of anti-hypertensive drugs that includes the hair-growth-inducing agent minoxidil. Recent work suggests potassium channel openers (PCOs) also influence hair gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0038cf3a111275e4ad2a1d73b7463c18
https://pubmed.ncbi.nlm.nih.gov/8326149
https://pubmed.ncbi.nlm.nih.gov/8326149