Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Daniel J. Spade"'
Autor:
Maha A. Alhasnani, Skylar Loeb, Susan J. Hall, Zachary Caruolo, Faith Simmonds, Amanda E. Solano, Daniel J. Spade
Publikováno v:
Current Research in Toxicology, Vol 3, Iss , Pp 100087- (2022)
Phthalic acid esters (phthalates) are a class of industrial chemicals that cause developmental and reproductive toxicity, but there are significant gaps in knowledge of phthalate toxicity mechanisms. There is evidence that phthalates disrupt retinoic
Externí odkaz:
https://doaj.org/article/fc51fd5ec487471cba10cb8f94e91f54
Publikováno v:
Frontiers in Genetics, Vol 3 (2012)
The new technologies for next-generation sequencing and global gene expression analyses that are widely used in molecular medicine are increasingly applied to the field of fish biology. This has facilitated new directions to address research areas th
Externí odkaz:
https://doaj.org/article/0660a674e4024748b7b68a5c0b52c5ec
Autor:
Hui Li, Daniel J. Spade
Publikováno v:
Reproduction
Fetal development of the mammalian testis relies on a series of interrelated cellular processes: commitment of somatic progenitor cells to Sertoli and Leydig cell fate, migration of endothelial cells and Sertoli cells, differentiation of germ cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8fde7f38c0ff2bc69be1d5fe318d79
https://doi.org/10.1530/rep-20-0592
https://doi.org/10.1530/rep-20-0592
Publikováno v:
Toxicological Sciences. 168:149-159
Humans are universally exposed to low levels of phthalate esters (phthalates), which are used to plasticize polyvinyl chloride. Phthalates exert adverse effects on the development of seminiferous cords in the fetal testis through unknown toxicity pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6662cbae28fed3dc885b9d95b64178
https://doi.org/10.1093/toxsci/kfy283
https://doi.org/10.1093/toxsci/kfy283
Autor:
Christoph Schorl, Daniel J. Spade, Kim Boekelheide, Edward Dere, Richard N. Freiman, Susan J. Hall
Publikováno v:
Toxicological Sciences. 167:546-558
Exposure to excess retinoic acid (RA) disrupts the development of the mammalian testicular seminiferous cord. However, the molecular events surrounding RA-driven loss of cord structure have not previously been examined. To investigate the mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fdbaed0cb7296bc02f4a7bc9489fb6
https://doi.org/10.1093/toxsci/kfy260
https://doi.org/10.1093/toxsci/kfy260
Autor:
Kim Boekelheide, Michelle Vanlandingham, Sherry M. Lewis, Edward Dere, Susan J. Hall, Samantha J. Madnick, Daniel J. Spade, Linnea M. Anderson, Luísa Camacho, Susan M. Huse, Elizabeth V. McDonnell-Clark
Publikováno v:
Toxicology and Applied Pharmacology. 347:1-9
Bisphenol A (BPA) is a ubiquitous industrial chemical that has been identified as an endocrine disrupting compound (EDC). There is growing concern that early life exposures to EDCs, such as BPA, can adversely affect the male reproductive tract and fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c5ba281948862fc6f9377c1a135972
https://doi.org/10.1016/j.taap.2018.03.021
https://doi.org/10.1016/j.taap.2018.03.021
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0229967 (2020)
PLoS ONE, Vol 15, Iss 7, p e0229967 (2020)
Phthalic acid esters (phthalates) are male reproductive toxicants, which exert their most potent toxicity during a critical window of sensitivity in fetal development. In the fetal rat, exposure to phthalates reduces testosterone biosynthesis, alters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1a1ac2de34404d26daff6ead372908
https://doi.org/10.1371/journal.pone.0229967
https://doi.org/10.1371/journal.pone.0229967
Autor:
Kim Boekelheide, Daniel J. Spade, L. Earl Gray, Justin M. Conley, Cathy Yue Bai, Christy S. Lambright
In utero exposure to certain phthalate esters results in testicular toxicity, characterized at the tissue level by induction of multinucleated germ cells (MNGs) in rat, mouse, and human fetal testis. Phthalate exposures also result in a decrease in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec26945bd8b6e592e873cb18a441984
https://europepmc.org/articles/PMC5921076/
https://europepmc.org/articles/PMC5921076/
Autor:
Daniel J. Spade, Monique E. De Paepe, Kim Boekelheide, Philip A. Gruppuso, Jennifer A. Sanders, Elizabeth V. McDonnell, Camelia M. Saffarini, Nicholas E. Heger
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 101:410-422
Many diseases that manifest throughout the lifetime are influenced by factors affecting fetal development. Fetal exposure to xenobiotics, in particular, may influence the development of adult diseases. Established animal models provide systems for ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f1dc598ae28abb5dfa455479c358438
https://doi.org/10.1002/bdrb.21131
https://doi.org/10.1002/bdrb.21131