Region‐based epigenetic clock design improves RRBS‐based age prediction

Autor: Daniel J. Simpson, Qian Zhao, Nelly N. Olova, Jan Dabrowski, Xiaoxiao Xie, Eric Latorre Crespo, Tamir Chandra

Publikováno v: Simpson, D, Zhao, Q, Olova, N, Dabrowski, J, Xie, X, Latorre Crespo, E & Chandra, T 2023, ' Region-based epigenetic clock design improves RRBS-based age prediction ', Aging Cell . https://doi.org/10.1111/acel.13866

Recent studies suggest that epigenetic rejuvenation can be achieved using drugs that mimic calorie restriction and techniques such as reprogramming induced rejuvenation. To effectively test rejuvenationin vivo, mouse models are the safest alternative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ae38761cd5e1b3a3ea58cb2fb59ae6
https://doi.org/10.1111/acel.13866

Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair

Autor: Juan Carlos Lopez-Baez, Daniel J Simpson, Laura LLeras Forero, Zhiqiang Zeng, Hannah Brunsdon, Angela Salzano, Alessandro Brombin, Cameron Wyatt, Witold Rybski, Leonie F A Huitema, Rodney M Dale, Koichi Kawakami, Christoph Englert, Tamir Chandra, Stefan Schulte-Merker, Nicholas D Hastie, E Elizabeth Patton

Publikováno v: eLife, Vol 7 (2018)

Regenerative therapy for degenerative spine disorders requires the identification of cells that can slow down and possibly reverse degenerative processes. Here, we identify an unanticipated wound-specific notochord sheath cell subpopulation that expr

Externí odkaz: https://doaj.org/article/00683b5eb8b74856bfb9c33328c37974

Cellular reprogramming and epigenetic rejuvenation

Autor: Daniel J. Simpson, Nelly Olova, Tamir Chandra

Publikováno v: Clinical Epigenetics
Simpson, D J, Olova, N N & Chandra, T 2021, ' Cellular reprogramming and epigenetic rejuvenation ', Clinical Epigenetics, vol. 13, no. 1, 170 . https://doi.org/10.1186/s13148-021-01158-7

Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing the ageing process might be possible. Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4642a68a4bb05faef036e40caed69097
http://europepmc.org/articles/PMC8419998

Tfap2b specifies an embryonic melanocyte stem cell that retains adult multi-fate potential

Autor: Alessandro Brombin, Daniel J. Simpson, Jana Travnickova, Hannah Brunsdon, Zhiqiang Zeng, Yuting Lu, Adelaide I.J. Young, Tamir Chandra, E. Elizabeth Patton

SummaryMelanocytes, our pigment producing cells, are replenished from multiple stem cell niches in adult tissues. Although pigmentation traits are known risk-factors for melanoma, we know little about melanocyte stem cell (McSC) populations other tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62d8a3a0141fecd562dae66d2d731146
https://doi.org/10.1101/2021.06.18.448859

Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease

Autor: Cécile Bénézech, Carolynn Cairns, Oliver Teenan, Katie Connor, James O’sullivan, Angela Salzano, David A. Ferenbach, Kevin Stewart, Eoin O'Sullivan, Neil C. Henderson, Peng Ding, Riinu Pius, Jeremy Hughes, Tamir Chandra, Laura Denby, Duncan Humphries, Prakash Ramachandran, Bryan R. Conway, Daniel J. Simpson

Publikováno v: J Am Soc Nephrol
Conway, B R, O Sullivan, E, Cairns, C, O'Sullivan, J, Simpson, D, Salzano, A, Connor, K, Ding, P, Humphries, D, Stewart, K, Teenan, O, Pius, R, Henderson, N C, Benezech, C, Ramachandran, P, Ferenbach, D A, Hughes, J, Chandra, T & Denby, L 2020, ' Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease ', Journal of the American Society of Nephrology, vol. 31, no. 12, pp. 2833–2854 . https://doi.org/10.1681/ASN.2020060806

Background Little is known about the roles of myeloid cell subsets in kidney injury and in the limited ability of the organ to repair itself. Characterizing these cells based only on surface markers using flow cytometry might not provide a full pheno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c985622a807b7b39dbcfe20eb66ca7
https://pubmed.ncbi.nlm.nih.gov/32978267