Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Daniel J. Simpson"'
Autor:
Mahdi Moqri, Andrea Cipriano, Daniel J. Simpson, Sajede Rasouli, Tara Murty, Tineke Anna de Jong, Daniel Nachun, Guilherme de Sena Brandine, Kejun Ying, Andrei Tarkhov, Karolina A. Aberg, Edwin van den Oord, Wanding Zhou, Andrew Smith, Crystal Mackall, Vadim N. Gladyshev, Steve Horvath, Michael P. Snyder, Vittorio Sebastiano
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract DNA methylation (DNAm) is one of the most reliable biomarkers of aging across mammalian tissues. While the age-dependent global loss of DNAm has been well characterized, DNAm gain is less characterized. Studies have demonstrated that CpGs wh
Externí odkaz:
https://doaj.org/article/903dd1a324284990bb38ba6fe77d4c37
Autor:
Daniel J. Simpson, Qian Zhao, Nelly N. Olova, Jan Dabrowski, Xiaoxiao Xie, Eric Latorre Crespo, Tamir Chandra
Publikováno v:
Simpson, D, Zhao, Q, Olova, N, Dabrowski, J, Xie, X, Latorre Crespo, E & Chandra, T 2023, ' Region-based epigenetic clock design improves RRBS-based age prediction ', Aging Cell . https://doi.org/10.1111/acel.13866
Recent studies suggest that epigenetic rejuvenation can be achieved using drugs that mimic calorie restriction and techniques such as reprogramming induced rejuvenation. To effectively test rejuvenationin vivo, mouse models are the safest alternative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ae38761cd5e1b3a3ea58cb2fb59ae6
https://doi.org/10.1111/acel.13866
https://doi.org/10.1111/acel.13866
Autor:
Jan. K. Dabrowski, Emma. J. Yang, Samuel. J. C. Crofts, Robert. F. Hillary, Daniel. J. Simpson, Daniel. L. Mccartney, Riccardo. E. Marioni, Eric Latorre-Crespo, Tamir Chandra
The emergence of epigenetic predictors was a pivotal moment in geroscience, propelling the measurement and concept of biological ageing into a quantitative era. However, while current epigenetic clocks have shown strong predictive power, they do not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17c9e902fd8f38ccfdea27536d507a74
https://doi.org/10.1101/2023.03.01.530570
https://doi.org/10.1101/2023.03.01.530570
Autor:
Juan Carlos Lopez-Baez, Daniel J Simpson, Laura LLeras Forero, Zhiqiang Zeng, Hannah Brunsdon, Angela Salzano, Alessandro Brombin, Cameron Wyatt, Witold Rybski, Leonie F A Huitema, Rodney M Dale, Koichi Kawakami, Christoph Englert, Tamir Chandra, Stefan Schulte-Merker, Nicholas D Hastie, E Elizabeth Patton
Publikováno v:
eLife, Vol 7 (2018)
Regenerative therapy for degenerative spine disorders requires the identification of cells that can slow down and possibly reverse degenerative processes. Here, we identify an unanticipated wound-specific notochord sheath cell subpopulation that expr
Externí odkaz:
https://doaj.org/article/00683b5eb8b74856bfb9c33328c37974
Publikováno v:
Clinical Epigenetics
Simpson, D J, Olova, N N & Chandra, T 2021, ' Cellular reprogramming and epigenetic rejuvenation ', Clinical Epigenetics, vol. 13, no. 1, 170 . https://doi.org/10.1186/s13148-021-01158-7
Simpson, D J, Olova, N N & Chandra, T 2021, ' Cellular reprogramming and epigenetic rejuvenation ', Clinical Epigenetics, vol. 13, no. 1, 170 . https://doi.org/10.1186/s13148-021-01158-7
Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing the ageing process might be possible. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4642a68a4bb05faef036e40caed69097
http://europepmc.org/articles/PMC8419998
http://europepmc.org/articles/PMC8419998
Autor:
Tamir Chandra, Daniel J. Simpson
Publikováno v:
Aging Cell
Advanced age is the main common risk factor for cancer, cardiovascular disease and neurodegeneration. Yet, more is known about the molecular basis of any of these groups of diseases than the changes that accompany ageing itself. Progress in molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d095dbc0950ea89278676a6dd1e1ded
https://doi.org/10.1111/acel.13452
https://doi.org/10.1111/acel.13452
Autor:
Alessandro Brombin, Daniel J. Simpson, Jana Travnickova, Hannah Brunsdon, Zhiqiang Zeng, Yuting Lu, Adelaide I.J. Young, Tamir Chandra, E. Elizabeth Patton
SummaryMelanocytes, our pigment producing cells, are replenished from multiple stem cell niches in adult tissues. Although pigmentation traits are known risk-factors for melanoma, we know little about melanocyte stem cell (McSC) populations other tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62d8a3a0141fecd562dae66d2d731146
https://doi.org/10.1101/2021.06.18.448859
https://doi.org/10.1101/2021.06.18.448859
Autor:
Jana Travnickova, Yuting Lu, Hannah Brunsdon, Zhiqiang Zeng, Daniel J. Simpson, Alessandro Brombin, E. Elizabeth Patton, Tamir Chandra
Publikováno v:
SSRN Electronic Journal.
Melanocytes, our pigment producing cells, are replenished from multiple stem cell niches in adult tissues. Although pigmentation traits are known risk-factors for melanoma, we know little about melanocyte stem cell (MSC) populations other than hair f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db42b44da12f8b17ae47d49fafea7a9c
https://doi.org/10.2139/ssrn.3882135
https://doi.org/10.2139/ssrn.3882135
Autor:
Cécile Bénézech, Carolynn Cairns, Oliver Teenan, Katie Connor, James O’sullivan, Angela Salzano, David A. Ferenbach, Kevin Stewart, Eoin O'Sullivan, Neil C. Henderson, Peng Ding, Riinu Pius, Jeremy Hughes, Tamir Chandra, Laura Denby, Duncan Humphries, Prakash Ramachandran, Bryan R. Conway, Daniel J. Simpson
Publikováno v:
J Am Soc Nephrol
Conway, B R, O Sullivan, E, Cairns, C, O'Sullivan, J, Simpson, D, Salzano, A, Connor, K, Ding, P, Humphries, D, Stewart, K, Teenan, O, Pius, R, Henderson, N C, Benezech, C, Ramachandran, P, Ferenbach, D A, Hughes, J, Chandra, T & Denby, L 2020, ' Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease ', Journal of the American Society of Nephrology, vol. 31, no. 12, pp. 2833–2854 . https://doi.org/10.1681/ASN.2020060806
Conway, B R, O Sullivan, E, Cairns, C, O'Sullivan, J, Simpson, D, Salzano, A, Connor, K, Ding, P, Humphries, D, Stewart, K, Teenan, O, Pius, R, Henderson, N C, Benezech, C, Ramachandran, P, Ferenbach, D A, Hughes, J, Chandra, T & Denby, L 2020, ' Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease ', Journal of the American Society of Nephrology, vol. 31, no. 12, pp. 2833–2854 . https://doi.org/10.1681/ASN.2020060806
Background Little is known about the roles of myeloid cell subsets in kidney injury and in the limited ability of the organ to repair itself. Characterizing these cells based only on surface markers using flow cytometry might not provide a full pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c985622a807b7b39dbcfe20eb66ca7
https://pubmed.ncbi.nlm.nih.gov/32978267
https://pubmed.ncbi.nlm.nih.gov/32978267
Autor:
Angela Salzano, Katie Connor, Oliver Teenan, Carolynn Cairns, Peng Ding, Jeremy Hughes, Tamir Chandra, Duncan Humphries, David A. Ferenbach, James O’sullivan, Eoin O'Sullivan, Cécile Bénézech, Kevin Stewart, Bryan R. Conway, Neil C. Henderson, Prakash Ramachandran, Laura Denby, Daniel J. Simpson
The kidney has a limited capacity to repair following injury, however, the endogenous reparative pathways are not well understood. Here we employ integrated droplet- and plate-based scRNA-seq in the murine reversible unilateral ureteric obstruction m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3634dd208de10fa924991efa0e0544d4
https://doi.org/10.1101/2020.05.14.095166
https://doi.org/10.1101/2020.05.14.095166