Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Daniel J. Sillence"'
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 8, Pp 1252-1260 (2000)
In the present study, 2,2,6,6-tetramethylpiperidinooxy nitroxide (TEMPO) has been applied successfully to discriminate between glucosylceramide in the outer and inner leaflets of closed membrane bilayers. The nitroxyl radicals TEMPO and carboxy-TEMPO
Externí odkaz:
https://doaj.org/article/1ebb73878dc74d05a078f59f09100187
Autor:
Tyra S.C. Zetterström, Tiziana Sgamma, Jinit Masania, Eva Masiero, Randolph R.J. Arroo, Estabraq Jaddoa, Daniel J. Sillence
Publikováno v:
Journal of Psychopharmacology. 34:716-725
Background:Major depression is a common mood disorder and the central sphingolipid system has been identified as a possible drug target of this condition. Here we investigated the action of antidepressant drugs on sphingolipid levels in rat brain reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcccf635138c8d82011fe8fec8857eea
https://doi.org/10.1177/0269881120915412
https://doi.org/10.1177/0269881120915412
Autor:
Simon Wheeler, Daniel J. Sillence
Publikováno v:
Journal of Neurochemistry. 153:674-692
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Niemann-Pick type C disease (NPCD) was first described in 1914 and affects approximately 1 in 150,000
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d382ffc7e287989f00253d70648fc262
https://doi.org/10.1111/jnc.14895
https://doi.org/10.1111/jnc.14895
Autor:
David Halter, Johannes M. F. G. Aerts, Daniel J. Sillence, Hein Sprong, Maria J. Ferraz, Meenakshi Bhardwaj, Per Haberkant, Simon Wheeler, Ralf Schmid, Paige Tongue, Nikol Sullo
Publikováno v:
Neurobiology of Disease, Vol 127, Iss, Pp 242-252 (2019)
A new paradigm for Niemann-Pick C disease is presented where lysosomal storage leads to a deficit in cytoplasmic glucosylceramide (GlcCer) where it performs important functions. Previously it had been reported that Gaucher cells have defective endoly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc20e61e0a111f8fd0b3a459259b6fa
http://hdl.handle.net/10029/622921
http://hdl.handle.net/10029/622921
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 3
International Journal of Molecular Sciences, Vol 20, Iss 3, p 717 (2019)
Volume 20
Issue 3
International Journal of Molecular Sciences, Vol 20, Iss 3, p 717 (2019)
The accumulation of lipids in the late endosomes and lysosomes of Niemann&ndash
Pick type C disease (NPCD) cells is a consequence of the dysfunction of one protein (usually NPC1) but induces dysfunction in many proteins. We used molecular dockin
Pick type C disease (NPCD) cells is a consequence of the dysfunction of one protein (usually NPC1) but induces dysfunction in many proteins. We used molecular dockin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9bf57dfe10586a4df4339fd42998b3
Autor:
Martin Grootveld, Daniel J. Sillence, Victor Ruiz-Rodado, Peter E. Clayton, Jackie Imrie, Frances M. Platt, D te Vruchte, Robin H. Lachmann, David Elizondo, Christian J. Hendriksz, James E. Wraith, Rafael Marcos Luque-Baena, Fay Probert
Publikováno v:
Current Metabolomics. 2:88-121
Niemann-Pick Class 1 (NPC1) disease is a rare, debilitating neurodegenerative lysosomal storage disease; however, urinary biomarkers available for it and its prognosis are currently limited. In order to identify and establish such biomarkers, we empl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8fe0effac540d5121dd9ae43bf641f
https://doi.org/10.2174/2213235x02666141112215616
https://doi.org/10.2174/2213235x02666141112215616
Autor:
Daniel J. Sillence, Frances M. Platt
Studying human diseases can help us to uncover important processes in normal cells. Cell biologists have recently focused on inherited sphingolipid-storage diseases. Eukaryotic life is characterized by internal membranes of various compositions, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3a919d1bb364acff799d4bc794b465
https://doi.org/10.1016/s0962-8924(03)00033-3
https://doi.org/10.1016/s0962-8924(03)00033-3
Autor:
Kate Riddick, Clare Taylor, Yasmina Amraoui, Uma Ramaswami, Frances M. Platt, Xuntian Jiang, Daniel S. Ory, David Smith, Robin H. Lachmann, Daniel J. Sillence, Heiko Runz, Rohini Sidhu, Florian Rimmele, Caroline A. Hastings, Naomi Wright, Begona Arias, Anneliese O. Speak, Alison Cousins, Kerri L. Wallom, Michael Beck, Mylvaganam Jeyakumar, Louise Simmons, R. Hartung, Eugen Mengel, Christopher A. Wassif, Timothy M. Cox, Nicole M. Yanjanin, Danielle te Vruchte, Jackie Imrie, Christian J. Hendriksz, Nada Al Eisa, James E. Wraith, Arndt Rolfs, Mario Cortina-Borja, Elizabeth Jacklin, Forbes D. Porter
Lysosomal storage disorders (LSDs) occur at a frequency of 1 in every 5,000 live births and are a common cause of pediatric neurodegenerative disease. The relatively small number of patients with LSDs and lack of validated biomarkers are substantial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5488da15647e4ba656436a6876745a
http://hdl.handle.net/2086/9855
http://hdl.handle.net/2086/9855
Autor:
David Allan, Daniel J. Sillence
Publikováno v:
Biochemical Journal. 331:251-256
1. After the degradation of cell-surface sphingomyelin (SM) by exogenous sphingomyelinase (SMase), the resynthesis of SM by baby-hamster kidney (BHK) and human leukaemia-60 (HL-60) cells was examined in relation to utilization of substrate phosphatid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4bae5f1809282c508eca5eaf6f7c1d
https://doi.org/10.1042/bj3310251
https://doi.org/10.1042/bj3310251
Autor:
Daniel J. Sillence
GlcCer accumulation causes Gaucher disease where GlcCer breakdown is inhibited due to a hereditary deficiency in glucocerebrosidase. Glycolipids are endocytosed and targeted to the Golgi apparatus in normal cells but in Gaucher disease they are mista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e672652695c0c0a498e3e38f1117cd40
https://doi.org/10.1016/j.ymgme.2013.03.015
https://doi.org/10.1016/j.ymgme.2013.03.015