Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Daniel J. Salamango"'
Autor:
Nicholas Saladino, Daniel J. Salamango
Publikováno v:
Frontiers in Virology, Vol 4 (2024)
Viruses are obligate intracellular pathogens that hijack a myriad of host cell processes to facilitate replication and suppress host antiviral defenses. In its essence, a virus is a segment of foreign nucleic acid that engages host cell machinery to
Externí odkaz:
https://doaj.org/article/03895b3141774db28cc86d2032946b90
Autor:
Daniel J. Salamango
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTThe severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak took the world by storm due to its rapid global spread and unpredictable disease outcomes. The extraordinary ascension of SARS-CoV-2 to pandemic status motivated a worl
Externí odkaz:
https://doaj.org/article/cf76bcdd511f453f818db35c3b235b9d
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011634 (2023)
Emerging evidence indicates that HIV-1 hijacks host DNA damage repair (DDR) pathways to facilitate multiple facets of virus replication. Canonically, HIV-1 engages proviral DDR responses through the accessory protein Vpr, which induces constitutive a
Externí odkaz:
https://doaj.org/article/3afa5a1c55574d4fab8c41257a419725
Autor:
Jonas N. Conde, Grace E. Himmler, Megan C. Mladinich, Yin Xiang Setoh, Alberto A. Amarilla, William R. Schutt, Nicholas Saladino, Elena E. Gorbunova, Daniel J. Salamango, Jorge Benach, Hwan Keun Kim, Erich R. Mackow
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Powassan virus (POWV) is an emerging tick-borne Flavivirus that causes lethal encephalitis and long-term neurologic damage. Currently, there are no POWV therapeutics, licensed vaccines, or reverse genetics systems for producing infectious PO
Externí odkaz:
https://doaj.org/article/f22f350794334089a5acab753f02c7f9
Autor:
Ashley A. Auerbach, Jordan T. Becker, Sofia N. Moraes, Seyed Arad Moghadasi, Jolene M. Duda, Daniel J. Salamango, Reuben S. Harris
Publikováno v:
mSphere, Vol 7, Iss 6 (2022)
ABSTRACT APOBEC3B is an innate immune effector enzyme capable of introducing mutations in viral genomes through DNA cytosine-to-uracil editing. Recent studies have shown that gamma-herpesviruses, such as Epstein-Barr virus (EBV), have evolved a poten
Externí odkaz:
https://doaj.org/article/a41bf03117264cc4867ed3105146f18f
Autor:
Veer Bhatt, Ke Shi, Daniel J. Salamango, Nicholas H. Moeller, Krishan K. Pandey, Sibes Bera, Thomas E. Bohl, Fredy Kurniawan, Kayo Orellana, Wei Zhang, Duane P. Grandgenett, Reuben S. Harris, Anna C. Sundborger-Lunna, Hideki Aihara
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Integration of the reverse-transcribed viral DNA into host chromosomes is a critical step in the life-cycle of retroviruses such as the human T-cell leukemia virus type-1 (HTLV-1). Here the authors describe the structural role of the host co-factor p
Externí odkaz:
https://doaj.org/article/aa9b53faafb14e34a356550f154c5e2f
Publikováno v:
Viruses, Vol 14, Iss 8, p 1701 (2022)
The canonical function of lentiviral Vif proteins is to counteract the mutagenic potential of APOBEC3 antiviral restriction factors. However, recent studies have discovered that Vif proteins from diverse HIV-1 and simian immunodeficiency virus (SIV)
Externí odkaz:
https://doaj.org/article/1dfecc85b7954c4f9e380bfbb2f85581
Autor:
Daniel J. Salamango, Reuben S. Harris
Publikováno v:
Frontiers in Microbiology, Vol 11 (2021)
Accessory proteins are a key feature that distinguishes primate immunodeficiency viruses such as human immunodeficiency virus type I (HIV-1) from other retroviruses. A prime example is the virion infectivity factor, Vif, which hijacks a cellular co-t
Externí odkaz:
https://doaj.org/article/9d6dc841fd82419cb920cfcab378dc6f
Autor:
Diako Ebrahimi, Christopher M. Richards, Michael A. Carpenter, Jiayi Wang, Terumasa Ikeda, Jordan T. Becker, Adam Z. Cheng, Jennifer L. McCann, Nadine M. Shaban, Daniel J. Salamango, Gabriel J. Starrett, Jairam R. Lingappa, Jeongsik Yong, William L. Brown, Reuben S. Harris
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Human APOBEC3H has several haplotypes and splice variants with distinct anti-HIV-1 activities, but the genetics underlying the expression of these variants are unclear. Here, the authors identify an intronic deletion in A3H haplotype II resulting in
Externí odkaz:
https://doaj.org/article/ea3b48a2ed974a7c8e6b38190a93470e
Autor:
Daniel J. Salamango, Terumasa Ikeda, Seyed Arad Moghadasi, Jiayi Wang, Jennifer L. McCann, Artur A. Serebrenik, Diako Ebrahimi, Matthew C. Jarvis, William L. Brown, Reuben S. Harris
Publikováno v:
Cell Reports, Vol 29, Iss 5, Pp 1057-1065.e4 (2019)
Summary: HIV-1 Vif hijacks a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 enzymes and PP2A phosphatase regulators (PPP2R5A–E). APOBEC3 counteraction is essential for viral pathogenesis. However, Vif also functions through an unkno
Externí odkaz:
https://doaj.org/article/c1e98fbb6c6d4901afc605ca1d57b854