Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Daniel J. Perry"'
Autor:
Daniel J. Perry, Melanie R. Shapiro, Sonya W. Chamberlain, Irina Kusmartseva, Srikar Chamala, Leandro Balzano-Nogueira, Mingder Yang, Jason O. Brant, Maigan Brusko, MacKenzie D. Williams, Kieran M. McGrail, James McNichols, Leeana D. Peters, Amanda L. Posgai, John S. Kaddis, Clayton E. Mathews, Clive H. Wasserfall, Bobbie-Jo M. Webb-Robertson, Martha Campbell-Thompson, Desmond Schatz, Carmella Evans-Molina, Alberto Pugliese, Patrick Concannon, Mark S. Anderson, Michael S. German, Chester E. Chamberlain, Mark A. Atkinson, Todd M. Brusko
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-16 (2023)
Abstract The Network for Pancreatic Organ donors with Diabetes (nPOD) is the largest biorepository of human pancreata and associated immune organs from donors with type 1 diabetes (T1D), maturity-onset diabetes of the young (MODY), cystic fibrosis-re
Externí odkaz:
https://doaj.org/article/0ad4cb66140840c5abd02c69201bad7b
Autor:
Melanie R. Shapiro, Xiaoru Dong, Daniel J. Perry, James M. McNichols, Puchong Thirawatananond, Amanda L. Posgai, Leeana D. Peters, Keshav Motwani, Richard S. Musca, Andrew Muir, Patrick Concannon, Laura M. Jacobsen, Clayton E. Mathews, Clive H. Wasserfall, Michael J. Haller, Desmond A. Schatz, Mark A. Atkinson, Maigan A. Brusko, Rhonda Bacher, Todd M. Brusko
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
The proportions and phenotypes of immune cell subsets in peripheral blood undergo continual and dramatic remodeling throughout the human life span, which complicates efforts to identify disease-associated immune signatures in type 1 diabetes (T1D). W
Externí odkaz:
https://doaj.org/article/637333e5554a47dcb1444963f6436280
Autor:
Laura M. Jacobsen, Kirsten Diggins, Lori Blanchfield, James McNichols, Daniel J. Perry, Jason Brant, Xiaoru Dong, Rhonda Bacher, Vivian H. Gersuk, Desmond A. Schatz, Mark A. Atkinson, Clayton E. Mathews, Michael J. Haller, S. Alice Long, Peter S. Linsley, Todd M. Brusko
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
BACKGROUND Low-dose anti–thymocyte globulin (ATG) transiently preserves C-peptide and lowers HbA1c in individuals with recent-onset type 1 diabetes (T1D); however, the mechanisms of action and features of the response remain unclear. Here, we chara
Externí odkaz:
https://doaj.org/article/ad46bb6a2d254bafb3f6b3213915a443
Autor:
Lucas H. Armitage, Scott E. Stimpson, Katherine E. Santostefano, Lina Sui, Similoluwa Ogundare, Brittney N. Newby, Roberto Castro-Gutierrez, Mollie K. Huber, Jared P. Taylor, Prerana Sharma, Ilian A. Radichev, Daniel J. Perry, Natalie C. Fredette, Alexei Y. Savinov, Mark A. Wallet, Naohiro Terada, Todd M. Brusko, Holger A. Russ, Jing Chen, Dieter Egli, Clayton E. Mathews
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Type 1 diabetes (T1D) is a disease that arises due to complex immunogenetic mechanisms. Key cell-cell interactions involved in the pathogenesis of T1D are activation of autoreactive T cells by dendritic cells (DC), migration of T cells across endothe
Externí odkaz:
https://doaj.org/article/4cc69f69404e4a1aa049c8589a0add98
Autor:
Keshav Motwani, Leeana D. Peters, Willem H. Vliegen, Ahmed Gomaa El-sayed, Howard R. Seay, M. Cecilia Lopez, Henry V. Baker, Amanda L. Posgai, Maigan A. Brusko, Daniel J. Perry, Rhonda Bacher, Joseph Larkin, Michael J. Haller, Todd M. Brusko
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The human T lymphocyte compartment is highly dynamic over the course of a lifetime. Of the many changes, perhaps most notable is the transition from a predominantly naïve T cell state at birth to the acquisition of antigen-experienced memory and eff
Externí odkaz:
https://doaj.org/article/99b03748c4ef44f296bba8a3bcfeb3b1
Autor:
Guillermo E. Marcial, Amanda L. Ford, Michael J. Haller, Salvador A. Gezan, Natalie A. Harrison, Dan Cai, Julie L. Meyer, Daniel J. Perry, Mark A. Atkinson, Clive H. Wasserfall, Timothy Garrett, Claudio F. Gonzalez, Todd M. Brusko, Wendy J. Dahl, Graciela L. Lorca
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Lactobacillus johnsonii N6.2 mitigates the onset of type 1 diabetes (T1D) in biobreeding diabetes-prone rats, in part, through changes in kynurenine:tryptophan (K:T) ratios. The goal of this pilot study was to determine the safety, tolerance, and gen
Externí odkaz:
https://doaj.org/article/2a3a8162db964ba2ab6dcd6da5e46c3d
Autor:
Brent A. Hanks, Jared R. Lowe, Daniel J. Perry, April K. S. Salama, Clayton E. Mathews, Larry G. Moss
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 4, Iss 1 (2016)
Background Checkpoint inhibitor immunotherapy is becoming an effective treatment modality for an increasing number of malignancies. As a result, autoinflammatory side-effects are also being observed more commonly in the clinic. We are currently unabl
Externí odkaz:
https://doaj.org/article/acd0943baabb42c8a52f1269cf663b34
Publikováno v:
Diseases, Vol 5, Iss 4, p 29 (2017)
Since the American Heart Association’s recommendation for familial screening of adults with congenital heart disease for bicuspid aortic valve, similar recommendations for other left-sided heart defects, such as hypoplastic left heart syndrome (HLH
Externí odkaz:
https://doaj.org/article/365de641096d4ce6b2bfa06988ec7d23
CAR- and TRuC-redirected regulatory T cells differ in capacity to control adaptive immunity to FVIII
Autor:
Jyoti Rana, Sandeep R. P. Kumar, Todd M. Brusko, Rania Saboungi, Moanaro Biswas, Maite Muñoz-Melero, Daniel J. Perry
Publikováno v:
Molecular Therapy. 29:2660-2676
Regulatory T cells (Tregs) control immune responses in autoimmune disease, transplantation, and enable antigen-specific tolerance induction in protein-replacement therapies. Tregs can exert a broad array of suppressive functions through their T cell
Autor:
Leeana D. Peters, Daniel J. Perry, Zhao Han, Clive Wasserfall, Mark A. Atkinson, Lin Zhang, Clayton E. Mathews, Todd M. Brusko, Priya Saikumar Lakshmi
Publikováno v:
J Immunol
A missense mutation (R620W) of protein tyrosine phosphatase nonreceptor type 22 (PTPN22), which encodes lymphoid-tyrosine phosphatase (LYP), confers genetic risk for multiple autoimmune diseases including type 1 diabetes. LYP has been putatively demo