Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Daniel J. Pasula"'
Autor:
Shugo Sasaki, Cuilan Nian, Eric E. Xu, Daniel J. Pasula, Helena Winata, Sanya Grover, Dan S. Luciani, Francis C. Lynn
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107311- (2023)
Summary: Restoring functional β cell mass is a potential therapy for those with diabetes. However, the pathways regulating β cell mass are not fully understood. Previously, we demonstrated that Sox4 is required for β cell proliferation during pred
Externí odkaz:
https://doaj.org/article/4b4e9944c9d2462ca5dbfa7c24f73e0c
Autor:
Aline Daniel, Cassandra L. McDonald, Brad G. Hoffman, Nina Maeshima, Dan S. Luciani, Ben Vanderkruk, Daniel J. Pasula, Meilin An, Priya Suresh
Publikováno v:
Diabetologia. 66:1097-1115
Aims/hypothesis Beta cells control glucose homeostasis via regulated production and secretion of insulin. This function arises from a highly specialised gene expression programme that is established during development and then sustained, with limited
Autor:
Shugo Sasaki, Cuilan Nian, Eric E. Xu, Daniel J. Pasula, Helena Winata, Sanya Grover, Dan S. Luciani, Francis C. Lynn
ObjectiveDiabetes onset is accompanied with β-cell deficiency, and thus restoring functional β-cell mass is a promising therapy for those with diabetes. However, the regulatory mechanisms controlling β-cell mass are not fully understood. Previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb725225f32dfb659cbd0f108cd8ac6
https://doi.org/10.1101/2022.12.23.521810
https://doi.org/10.1101/2022.12.23.521810
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
ER stress and apoptosis contribute to the loss of pancreatic β-cells under pro-diabetic conditions of glucolipotoxicity. Although activation of canonical intrinsic apoptosis is known to require pro-apoptotic Bcl-2 family proteins Bax and Bak, their
Autor:
Daniel J. Pasula, Ahsen Chaudhry, Rocky Shi, Yuanjie Zou, Dan S. Luciani, Alexis Z.L. Shih, Ben Vanderkruk, Brad Hoffman
In the progression of diabetes, pancreatic islet β-cells respond to increased metabolic demand with functional compensation, followed by pathogenic decompensation of mitochondria-dependent insulin secretion. It is not clear what mechanisms drive, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58daa21e10dd2c046b87e514db5e3a00
https://doi.org/10.1101/2021.10.25.465491
https://doi.org/10.1101/2021.10.25.465491
Publikováno v:
Diabetes. 70
Proinsulin (PI) is processed to mature insulin by prohormone convertases 1/3 (Pcsk1) and 2 (Pcsk2). In individuals with T1D and T2D, there is an increase in the circulating PI:insulin ratio. We hypothesized that β-cell Pcsk1 and Pcsk2 deletion would
Publikováno v:
Diabetes. 70
Autophagy can help protect stressed β-cells. We investigated if disruption of Transcription Factor EB (Tfeb), a transcriptional master-regulator of lysosomes and autophagy, contributes to β-cell failure and death under various ER stress-inducing co
Autor:
Alexis Z. L. Shih, Daniel J. Pasula, Ben Vanderkruk, Brad G. Hoffman, Rocky Shi, Ahsen Chaudhry, Dan S. Luciani
Publikováno v:
Canadian Journal of Diabetes. 45:S35
Autor:
Brad G. Hoffman, Ahsen Chaudry, Alexis Z. L. Shih, Ben Vanderkruk, Dan S. Luciani, Rocky Shi, Daniel J. Pasula
Publikováno v:
Canadian Journal of Diabetes. 44:S31
Autor:
Jahdiel Larraguibel, Daniel J. Pasula, Terence J. Van Raay, Rasmeet Singh Dhaliwal, Alexander R. E. Weiss, Roman Kondra
Publikováno v:
Molecular Biology of the Cell
Nkd1, a negative feedback regulator of the Wnt pathway, localizes with Dvl2 to the putative Wnt signalosome, where it becomes activated by Wnt. Activated Nkd1 moves away from the membrane to become more cytosolic, where it interacts with β-catenin t