An exercise physiologist's guide to metabolomics

Autor: Daniel J. Owens, Samuel Bennett

Publikováno v: Experimental Physiology, Vol 109, Iss 7, Pp 1066-1079 (2024)

Abstract The field of exercise physiology has undergone significant technological advancements since the pioneering works of exercise physiologists in the early to mid‐20th century. Historically, the ability to detect metabolites in biofluids from

Externí odkaz: https://doaj.org/article/49aa7d17ac3b4be3910438f3d5f627c0

Acute heat stress amplifies exercise‐induced metabolomic perturbations and reveals variation in circulating amino acids in endurance‐trained males

Autor: Samuel Bennett, Franck Brocherie, Marie M. Phelan, Eve Tiollier, Elodie Guibert, Antonio J. Morales‐Artacho, Paul Lalire, James P. Morton, Julien B. Louis, Daniel J. Owens

Publikováno v: Experimental Physiology, Vol 108, Iss 6, Pp 838-851 (2023)

Abstract Using untargeted metabolomics, we aimed to characterise the systemic impact of environmental heat stress during exercise. Twenty‐three trained male triathletes (V̇O2peak = 64.8 ± 9.2 ml kg min−1) completed a 30‐min exercise test in h

Externí odkaz: https://doaj.org/article/80a8421cd45249c285d71d11a735c79f

'Fuel for the Damage Induced': Untargeted Metabolomics in Elite Rugby Union Match Play

Autor: James F. Hudson, Marie M. Phelan, Daniel J. Owens, James P. Morton, Graeme L. Close, Claire E. Stewart

Publikováno v: Metabolites, Vol 11, Iss 8, p 544 (2021)

The metabolic perturbations caused by competitive rugby are not well characterized. Our aim is to utilize untargeted metabolomics to develop appropriate interventions, based on the metabolic fluctuations that occur in response to this collision-based

Externí odkaz: https://doaj.org/article/031ba62a60ff483797b80654380b4360

Lamin Mutations Cause Increased YAP Nuclear Entry in Muscle Stem Cells

Autor: Daniel J. Owens, Martina Fischer, Saline Jabre, Sophie Moog, Kamel Mamchaoui, Gillian Butler-Browne, Catherine Coirault

Publikováno v: Cells, Vol 9, Iss 4, p 816 (2020)

Mutations in the LMNA gene, encoding the nuclear envelope A-type lamins, are responsible for muscular dystrophies, the most severe form being the LMNA-related congenital muscular dystrophy (L-CMD), with severe defects in myonucleus integrity. We prev

Externí odkaz: https://doaj.org/article/cacc582cb6754e9ba0763b4b233ac557

PCM1 labelling reveals myonuclear and nuclear dynamics in skeletal muscle across species

Autor: Mark R. Viggars, Daniel J. Owens, Claire Stewart, Catherine Coirault, Abigail L. Mackey, Jonathan C. Jarvis

Publikováno v: American Journal of Physiology-Cell Physiology
American Journal of Physiology-Cell Physiology, 2022, Online ahead of print. ⟨10.1152/ajpcell.00285.2022⟩

Myonuclei transcriptionally regulate muscle fibers during homeostasis and adaptation to exercise. Their subcellular location and quantity are important when characterizing phenotypes of myopathies, the effect of treatments, and understanding the role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fee0ba25a946d75e99011e22a64573
https://pubmed.ncbi.nlm.nih.gov/36409178