Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Daniel J. Mason"'
Autor:
C. P. Baburajeev, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Daniel J. Mason, Julian E. Fuchs, Andreas Bender, Uri Barash, Israel Vlodavsky, Basappa, Kanchugarakoppal S. Rangappa
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-14 (2017)
Abstract Background Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target i
Externí odkaz:
https://doaj.org/article/e01302dd50ff4695a5fd63b691790625
Autor:
Daniel J. Mason, Richard T. Eastman, Richard P. I. Lewis, Ian P. Stott, Rajarshi Guha, Andreas Bender
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The parasite Plasmodium falciparum is the most lethal species of Plasmodium to cause serious malaria infection in humans, and with resistance developing rapidly novel treatment modalities are currently being sought, one of which being combinations of
Externí odkaz:
https://doaj.org/article/d46e12f59c654f68bd45ae12d75cc670
Autor:
Patricia Cogram, Richard Smith, Ian Roberts, Tim Guilliams, Clare Thibodeaux, Michael Tranfaglia, Daniel J. Mason, David R. Brown
Publikováno v:
Neuropharmacology. 147:74-86
Many available drugs have been repurposed as treatments for neurodevelopmental disorders. In the specific case of fragile X syndrome, many clinical trials of available drugs have been conducted with the goal of disease modification. In some cases, de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb02086c94908be44877ec3264bb4a74
https://doi.org/10.1016/j.neuropharm.2018.05.004
https://doi.org/10.1016/j.neuropharm.2018.05.004
Autor:
Hosadurga K Keerthy, Manoj Garg, Chakrabhavi D Mohan, Vikas Madan, Deepika Kanojia, Rangappa Shobith, Shivananju Nanjundaswamy, Daniel J Mason, Andreas Bender, Basappa, Kanchugarakoppal S Rangappa, H Phillip Koeffler
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107118 (2014)
The anti-apoptotic protein Bcl-2 is a well-known and attractive therapeutic target for cancer. In the present study the solution-phase T3P-DMSO mediated efficient synthesis of 2-amino-chromene-3-carbonitriles from alcohols, malanonitrile and phenols
Externí odkaz:
https://doaj.org/article/ec334f3735274b5a85eba3c8c2d4fc77
Combination effects of compounds are commonly discussed in relation to the treatment of complex and treatment resistance-prone illnesses like cancer, (auto-)immune disorders, and infectious diseases. However, traversing the whole combinatorial space
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d766a512fc1106a5efa9440c7b31465
https://doi.org/10.1016/b978-0-12-801238-3.11569-7
https://doi.org/10.1016/b978-0-12-801238-3.11569-7
Autor:
Zohar B. Weinstein, Idil Karakoc, Andreas Bender, Ian P. Stott, Daniel J. Mason, Nurdan Kuru, Selin Meral, Murat Cokol, Stephanie Kay Ashenden
Publikováno v:
Journal of Medicinal Chemistry. 60:3902-3912
Combination antibiotic therapies are clinically important in the fight against bacterial infections. However, the search space of drug combinations is large, making the identification of effective combinations a challenging task. Here, we present a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea6f9f5ce16b3615705ce258c52689a
https://doi.org/10.1021/acs.jmedchem.7b00204
https://doi.org/10.1021/acs.jmedchem.7b00204
Autor:
Richard J. Lewis, Krishna C. Bulusu, Andreas Bender, Daniel J. Mason, Yasaman Kalantar Motamedi, Rajarshi Guha, Eugene N. Muratov, Murat Cokol
Publikováno v:
Drug Discovery Today. 21(2):225-238
The development of treatments involving combinations of drugs is a promising approach towards combating complex or multifactorial disorders. However, the large number of compound combinations that can be generated, even from small compound collection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51b4abc747c1c1fdd15763baab1fc7e
Autor:
Shardul Paricharak, Mahabaleshwaraiah Neelgundmath, Obelannavar Kotresh, Koragere Rajashekar Dinesh, Xiaoyun Dai, Gautam Sethi, Andreas Bender, Kodappully Sivaraman Siveen, Basappa, Kanchugarakoppal S. Rangappa, Daniel J. Mason, Chakrabhavi Dhananjaya Mohan, Julian E. Fuchs, Feng Li
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:893-897
Hepatocellular carcinoma (HCC) is the fifth most common malignant tumor worldwide, and is the third most common cause of cancer related death. Constitutive activation of NF-κB is the underlying mechanism behind tumorigenesis and this protein regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29b07b05215984b0d4dd23666c2e1fe
https://doi.org/10.1016/j.bmcl.2014.12.065
https://doi.org/10.1016/j.bmcl.2014.12.065
Autor:
Andreas Bender, Israel Vlodavsky, Kanchugarakoppal S. Rangappa, Chakrabhavi Dhananjaya Mohan, C. P. Baburajeev, Shobith Rangappa, Uri Barash, Daniel J. Mason, Julian E. Fuchs, Basappa
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-14 (2017)
BMC Cancer
BMC Cancer
Background Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target in cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d1ba6c068796c11fcfd7602fb6dd16
https://www.repository.cam.ac.uk/handle/1810/264074
https://www.repository.cam.ac.uk/handle/1810/264074
Autor:
Kothanahally S. Sharath Kumar, Chakrabhavi Dhananjaya Mohan, Andreas Bender, Basappa, Daniel J. Mason, Julian E. Fuchs, C. P. Baburajeev, Kanchugarakoppal S. Rangappa, Shobith Rangappa, Alexey Yu. Sukhorukov, Mahendra Madegowda, Chandra, V. Srinivas, Swamy Jagadish
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(15)
In the present study, we used solution combustion synthesis-bismuth oxide (Bi2O3) as catalyst for the simple and efficient synthesis of 1,2-oxazine based derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazoles, 1-arylpiperazine and carbazoles. (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303ac58a6e4309ed7aae5cdd437191e7
https://pubmed.ncbi.nlm.nih.gov/26048794
https://pubmed.ncbi.nlm.nih.gov/26048794