Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Daniel J. Kosman"'
Autor:
Frances M. Smith, Daniel J. Kosman
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2024)
Introduction: Friedreich’s Ataxia (FRDA) is the most prevalent inherited ataxia. FRDA results from loss of Frataxin (FXN), an essential mitochondrial iron trafficking protein. FRDA starts with an early burst of neurodegeneration of the dorsal root
Externí odkaz:
https://doaj.org/article/8e199e6a8765432d8c515d9c602cb58c
Autor:
Shaina L. Rosenblum, Daniel J. Kosman
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
The redox properties that make iron an essential nutrient also make iron an efficient pro-oxidant. Given this nascent cytotoxicity, iron homeostasis relies on a combination of iron transporters, chaperones, and redox buffers to manage the non-physiol
Externí odkaz:
https://doaj.org/article/0acb44878e1c4ca2b3f8d1d7aa624fdb
Autor:
Frances M. Smith, Daniel J. Kosman
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Friedreich’s ataxia (FRDA) is a multi-faceted disease characterized by progressive sensory–motor loss, neurodegeneration, brain iron accumulation, and eventual death by hypertrophic cardiomyopathy. FRDA follows loss of frataxin (FXN), a mitochond
Externí odkaz:
https://doaj.org/article/2c214e683eb84dd48afba7a187c32286
Autor:
Elisa Flávia Luiz Cardoso Bailão, Patrícia de Sousa Lima, Mirelle Garcia Silva-Bailão, Alexandre Melo Bailão, Gabriel da Rocha Fernandes, Daniel J. Kosman, Célia Maria de Almeida Soares
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
Iron is an essential micronutrient for almost all organisms, including fungi. Usually, fungi can uptake iron through receptor-mediated internalization of a siderophore or heme, and/or reductive iron assimilation (RIA). Traditionally, the RIA pathway
Externí odkaz:
https://doaj.org/article/cce0ec757f184485b0e0c6769400cd21
Autor:
Ryan C. McCarthy, Daniel J. Kosman
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 8 (2015)
The transcellular trafficking of iron from the blood into the brain interstitium depends on iron uptake proteins in the apical membrane of brain microvascular capillary endothelial cells and efflux proteins at the basolateral, abluminal membrane. In
Externí odkaz:
https://doaj.org/article/6807eff6f9ea4ae99b1a222ed78193d1
Autor:
Frances M. Smith, Daniel J Kosman
Publikováno v:
bioRxiv
BackgroundFriedreich’s Ataxia (FRDA) is the most prevalent inherited ataxia; the disease results from loss of Frataxin, an essential mitochondrial iron trafficking protein. FRDA presents as neurodegeneration of the dorsal root ganglion and cerebell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfeae8b77590ec7079d7350e5ee58f5
https://doi.org/10.1101/2023.02.09.527936
https://doi.org/10.1101/2023.02.09.527936
Autor:
Daniel J. Kosman
Publikováno v:
Metallomics
Cell iron uptake in mammals is commonly distinguished by whether the iron is presented to the cell as transferrin-bound or not: TBI or NTBI. This generic perspective conflates TBI with canonical transferrin receptor, endosomal iron uptake, and NTBI w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674e463c9899ec123c050e6bbbc355b7
https://doi.org/10.1039/d0mt00065e
https://doi.org/10.1039/d0mt00065e
Autor:
Brittany L. Steimle, Danielle K. Bailey, Frances M. Smith, Shaina L. Rosenblum, Daniel J. Kosman
Publikováno v:
The Journal of biological chemistry. 298(8)
Manganese (II) accumulation in human brain microvascular endothelial cells is mediated by the metal-ion transporters ZRT IRT-like protein 8 (ZIP8) and ZRT IRT-like protein 14 (ZIP14). The plasma membrane occupancy of ZIP14, in particular, is increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06e2d662775828030aedd127ac13031
https://pubmed.ncbi.nlm.nih.gov/35787370
https://pubmed.ncbi.nlm.nih.gov/35787370
Publikováno v:
J Biol Chem
Manganese supports numerous neuronal functions but in excess is neurotoxic. Consequently, regulation of manganese flux at the blood–brain barrier (BBB) is critical to brain homeostasis. However, the molecular pathways supporting the transcellular t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d2c610ab05445711fa0657deff2b4b
https://doi.org/10.1074/jbc.ra119.009371
https://doi.org/10.1074/jbc.ra119.009371
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254794 (2021)
PLoS ONE
PLoS ONE
Iron and other transition metals, such as copper and manganese, are essential for supporting brain function, yet over-accumulation is cytotoxic. This over-accumulation of metals, particularly iron, is common to several neurological disorders; these i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7a7aee4b2a997d5c26ede3f44e2c00
https://doaj.org/article/8a2ce6d16ed64ce897df7e728b055785
https://doaj.org/article/8a2ce6d16ed64ce897df7e728b055785