Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Daniel J. Jagger"'
Autor:
Katie E. Smith, Jonathan Lezmy, I. Lorena Arancibia-Cárcamo, Anwen Bullen, Daniel J. Jagger, David Attwell
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114651- (2024)
Summary: Sound is encoded by action potentials in spiral ganglion neurons (SGNs), the auditory afferents from the cochlea. Rapid action potential transmission along SGNs is crucial for quick reactions to sounds, and binaural differences in action pot
Externí odkaz:
https://doaj.org/article/dbbb34c60cfe4b869f366b5bf8bd2259
Autor:
Dale Bryant, Valda Pauzuolyte, Neil J. Ingham, Aara Patel, Waheeda Pagarkar, Lucy A. Anderson, Katie E. Smith, Dale A. Moulding, Yeh C. Leong, Daniyal J. Jafree, David A. Long, Amina Al-Yassin, Karen P. Steel, Daniel J. Jagger, Andrew Forge, Wolfgang Berger, Jane C. Sowden, Maria Bitner-Glindzicz
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Norrie disease is caused by mutation of the NDP gene, presenting as congenital blindness followed by later onset of hearing loss. Protecting patients from hearing loss is critical for maintaining their quality of life. This study aimed to understand
Externí odkaz:
https://doaj.org/article/c0067fb493e84e5eb2bb68d97a3e6a6d
Autor:
Zakia A. Abdelhamed, Subaashini Natarajan, Gabrielle Wheway, Christopher F. Inglehearn, Carmel Toomes, Colin A. Johnson, Daniel J. Jagger
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 6, Pp 527-541 (2015)
Ciliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert syndromes. In this study we describe multi-organ develop
Externí odkaz:
https://doaj.org/article/c2ccea26d47b400d98e3ee479bab47c3
Autor:
Jimena Ballestero, Matthieu Recugnat, Jonathan Laudanski, Katie E. Smith, Daniel J. Jagger, Daniel Gnansia, David McAlpine
Publikováno v:
Trends in Hearing, Vol 19 (2015)
Improving the electrode-neuron interface to reduce current spread between individual electrodes has been identified as one of the main objectives in the search for future improvements in cochlear-implant performance. Here, we address this problem by
Externí odkaz:
https://doaj.org/article/59933af14d234bdaa435dbbb011a3574
Autor:
Daniel J. Jagger, Silvia Prades, Jonathan E. Gale, Gregory Heard, Robin Kopp, Annette Nicke, Katie E. Smith, Tobias Engel
Publikováno v:
The Journal of Neuroscience. 41:2615-2629
P2X7receptors (P2X7Rs) are associated with numerous pathophysiological mechanisms, and this promotes them as therapeutic targets for certain neurodegenerative conditions. However, the identity of P2X7R-expressing cells in the nervous system remains c
Autor:
Liyam Laraba, Lily Hillson, Julio Grimm de Guibert, Amy Hewitt, Maisie R Jaques, Tracy T Tang, Leonard Post, Emanuela Ercolano, Ganesha Rai, Shyh-Ming Yang, Daniel J Jagger, Waldemar Woznica, Philip Edwards, Aditya G Shivane, C Oliver Hanemann, David B Parkinson
Publikováno v:
Brain : a journal of neurology.
Schwannoma tumours typically arise on the eighth cranial nerve and are mostly caused by loss of the tumour suppressor Merlin (NF2). There are no approved chemotherapies for these tumours and the surgical removal of the tumour carries a high risk of d
Autor:
Cindy Yukimi Sonoda, João Paulo Kitajima, Ellen Ouyang, Gleiciele Alice Vieira-Silva, Debora Levy, Daniel J. Jagger, Laura Garcia E. Vasconcelos, Roberto Miquelino de Oliveira Beck, Regina Célia Mingroni-Netto, Navid Zebarjadi, Vinícius Magalhães Borges, Juliana Sampaio-Silva, Jeanne Oiticica, Ana Carla Batissoco, Larissa Tiburcio Rodrigues do Nascimento, Vinicius Pedroso-Campos, Ricardo Ferreira Bento, Alix Trouillet, Nicolas Grillet, Karina Lezirovitz, Signe Schuster Grasel
Publikováno v:
Hum Mol Genet
Here we define a ~200 Kb genomic duplication in 2p14 as the genetic signature that segregates with postlingual progressive sensorineural autosomal dominant hearing loss (HL) in 20 affected individuals from the DFNA58 family, first reported in 2009. T
Publikováno v:
Current Opinion in Physiology. 14:35-40
Loss of the sensory ‘hair cells’ (HCs) from the vestibular (balance) system of the inner ear results in dizziness and balance dysfunction contributing to falls. In the inner ears of non-mammalian vertebrates, there is spontaneous and complete rep
Publikováno v:
Journal of Neuroscience Research. 98:888-901
Transplantation of olfactory ensheathing cells (OECs) is a potential therapy for the regeneration of damaged neurons. While they maintain tissue homeostasis in the olfactory mucosa (OM) and olfactory bulb (OB), their regenerative properties also supp
Autor:
Dale Bryant, Valda Pauzuolyte, Neil J. Ingham, Aara Patel, Waheeda Pagarkar, Lucy A. Anderson, Katie E. Smith, Dale A. Moulding, Yeh C. Leong, Daniyal J. Jafree, David A. Long, Amina Al-Yassin, Karen P. Steel, Daniel J. Jagger, Andrew Forge, Wolfgang Berger, Jane C. Sowden, Maria Bitner-Glindzicz
Publikováno v:
JCI Insight, 7 (3)
Norrie disease is caused by mutation of the NDP gene, presenting as congenital blindness followed by later onset of hearing loss. Protecting patients from hearing loss is critical for maintaining their quality of life. This study aimed to understand