Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Daniel J. Hodson"'
Autor:
Mark Roschewski, Daniel J. Hodson
Publikováno v:
Haematologica, Vol 109, Iss 2 (2023)
Diffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell lymphoma curable even in advanced stages. DLBCL involving the central nervous system (CNS) is more difficult to cure and fewer treatment options exist. Primary CNS lymphoma (PCNSL) refers
Externí odkaz:
https://doaj.org/article/012360ca010441eea0efdc525a2f6980
Autor:
Simon J. Bulley, Anna Santarsieri, Isabel C. Lentell, Brendan O'Sullivan, Andrew Hodson, Oliver Firth, Shalal Sadullah, Annabel M. Follows, Mamatha Karanth, Sandra Young Min, Alexis Fowler, James Russell, Benjamin J. Uttenthal, Daniel J. Hodson, George A. Follows
Publikováno v:
eJHaem, Vol 3, Iss 4, Pp 1316-1320 (2022)
Abstract PEP‐C (prednisolone, etoposide, procarbazine and cyclophosphamide) is an orally administered daily chemotherapy regimen used with palliative intent in relapsed refractory lymphoma. To our knowledge, no data on PEP‐C have been reported si
Externí odkaz:
https://doaj.org/article/b0da25b3cbe54ba2bde7a8a9335c58f3
Autor:
Maurizio Mangolini, Alba Maiques-Diaz, Stella Charalampopoulou, Elena Gerhard-Hartmann, Johannes Bloehdorn, Andrew Moore, Giorgia Giachetti, Junyan Lu, Valar Nila Roamio Franklin, Chandra Sekkar Reddy Chilamakuri, Ilias Moutsopoulos, Andreas Rosenwald, Stephan Stilgenbauer, Thorsten Zenz, Irina Mohorianu, Clive D’Santos, Silvia Deaglio, Daniel J. Hodson, Jose I. Martin-Subero, Ingo Ringshausen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
NOTCH mutations are frequent in B cell malignancies. Here the authors use retroviral transduction of primary malignant B cells from Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL) patients to show that NOTCH1/2-mutations facilitate
Externí odkaz:
https://doaj.org/article/e779b836c8e440c8aa0f51dae36441ca
Autor:
Atish Kizhakeyil, Nurmahirah Binte Mohammed Zaini, Zhi Sheng Poh, Brandon Han Siang Wong, Xinpeng Loh, Aik Seng Ng, Zun Siong Low, Praseetha Prasannan, Chun Gong, Michelle Guet Khim Tan, Chandramouli Nagarajan, Dachuan Huang, Pang Wan Lu, Jing Quan Lim, Sharon Barrans, Choon Kiat Ong, Soon Thye Lim, Wee Joo Chng, George Follows, Daniel J. Hodson, Ming Qing Du, Yeow Tee Goh, Suat Hoon Tan, Nicholas Francis Grigoropoulos, Navin Kumar Verma
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-7 (2021)
Externí odkaz:
https://doaj.org/article/b9772dfe6e6c41dcb1618e30d5c691a1
Autor:
Rebecca Caeser, Miriam Di Re, Joanna A. Krupka, Jie Gao, Maribel Lara-Chica, João M. L. Dias, Susanna L. Cooke, Rachel Fenner, Zelvera Usheva, Hendrik F. P. Runge, Philip A. Beer, Hesham Eldaly, Hyo-Kyung Pak, Chan-Sik Park, George S. Vassiliou, Brian J. P. Huntly, Annalisa Mupo, Rachael J. M. Bashford-Rogers, Daniel J. Hodson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
A dearth of adequate preclinical models to faithfully mimic diffuse large B-cell lymphoma has hampered the identification of driver genes. Here, the authors present a co-culture system that enables ex vivo expansion, viral transduction and transforma
Externí odkaz:
https://doaj.org/article/d3c9bc11a5cc4cb39c1c847ddd0e75b2
Autor:
Maurizio Mangolini, Frederik Götte, Andrew Moore, Tim Ammon, Madlen Oelsner, Gloria Lutzny-Geier, Ludger Klein-Hitpass, James C. Williamson, Paul J. Lehner, Jan Dürig, Michael Möllmann, Lívia Rásó-Barnett, Katherine Hughes, Antonella Santoro, Simón Méndez-Ferrer, Robert A. J. Oostendorp, Ursula Zimber-Strobl, Christian Peschel, Daniel J. Hodson, Marc Schmidt-Supprian, Ingo Ringshausen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The Wnt pathway is one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL) and is activated in only a subset of patients; however, no universal drivers of the disease have been identified. Here the authors show that Notch2 and β
Externí odkaz:
https://doaj.org/article/c4f9c099f3104cabbf026773512a17d1
Publikováno v:
Open Biology, Vol 6, Iss 9 (2016)
Both B and T lymphocytes have signature traits that set them apart from other cell types. They actively and repeatedly rearrange their DNA in order to produce a unique and functional antigen receptor, they have potential for massive clonal expansion
Externí odkaz:
https://doaj.org/article/583c2385b4da4e30b293c4ae5a6800a3
Autor:
Michal Marek Hoppe, Patrick Jaynes, Fan Shuangyi, Yanfen Peng, Shruti Sridhar, Phuong Mai Hoang, Clementine Xin Liu, Sanjay De Mel, Limei Poon, Esther Hian Li Chan, Joanne Lee, Choon Kiat Ong, Tiffany Tang, Soon Thye Lim, Chandramouli Nagarajan, Nicholas F. Grigoropoulos, Soo-Yong Tan, Susan Swee-Shan Hue, Sheng-Tsung Chang, Shih-Sung Chuang, Shaoying Li, Joseph D. Khoury, Hyungwon Choi, Carl Harris, Alessia Bottos, Laura J. Gay, Hendrik F.P. Runge, Ilias Moutsopoulos, Irina Mohorianu, Daniel J. Hodson, Pedro Farinha, Anja Mottok, David W. Scott, Jason J. Pitt, Jinmiao Chen, Gayatri Kumar, Kasthuri Kannan, Wee Joo Chng, Yen Lin Chee, Siok-Bian Ng, Claudio Tripodo, Anand D. Jeyasekharan
Publikováno v:
Cancer Discovery. 13:1144-1163
Cancers often overexpress multiple clinically relevant oncogenes, but it is not known if combinations of oncogenes in cellular subpopulations within a cancer influence clinical outcomes. Using quantitative multispectral imaging of the prognostically
Autor:
Findlay Bewicke-Copley, Koorosh Korfi, Shamzah Araf, Brendan Hodkinson, Emil Kumar, Thomas Cummin, Margaret Ashton-Key, Sharon Barrans, Suzan van Hoppe, Cathy Burton, Mohamed Elshiekh, Simon Rule, Nicola Crosbie, Andrew Clear, Maria Calaminici, Hendrik Runge, Robert K. Hills, David W. Scott, Lisa M. Rimsza, Geetha Menon, Chulin Sha, John R. Davies, Ai Nagano, Andrew Davies, Daniel Painter, Alexandra Smith, John Gribben, Kikkeri N. Naresh, David R. Westhead, Jessica Okosun, Andrew Steele, Daniel J. Hodson, Sriram Balasubramanian, Peter Johnson, Jun Wang, Jude Fitzgibbon
Publikováno v:
Blood Advances. 7:845-855
Despite the effectiveness of immuno-chemotherapy, 40% of patients with diffuse large B-cell lymphoma (DLBCL) experience relapse or refractory disease. Longitudinal studies have previously focused on the mutational landscape of relapse but fell short
Autor:
Simon Crouch, Daniel Painter, Sharon L. Barrans, Eve Roman, Philip A. Beer, Susanna L. Cooke, Paul Glover, Suzan J.L. Van Hoppe, Nichola Webster, Stuart E. Lacy, Camilo Ruiz, Peter J. Campbell, Daniel J. Hodson, Russell Patmore, Cathy Burton, Alexandra Smith, Reuben M. Tooze
Publikováno v:
Blood Advances. 6:5716-5731
Follicular lymphoma (FL) is morphologically and clinically diverse, with mutations in epigenetic regulators alongside t(14;18) identified as disease-initiating events. Identification of additional mutational entities confirms this cancer’s heteroge