Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Daniel J. Ho"'
Autor:
Chaoyang Ye, Daniel J. Ho, Marilisa Neri, Chian Yang, Tripti Kulkarni, Ranjit Randhawa, Martin Henault, Nadezda Mostacci, Pierre Farmer, Steffen Renner, Robert Ihry, Leandra Mansur, Caroline Gubser Keller, Gregory McAllister, Marc Hild, Jeremy Jenkins, Ajamete Kaykas
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
RNA-seq is a powerful tool to investigate how drugs affect the transcriptome but library construction can be costly. Here the authors introduce DRUG-seq, an automated platform for high-throughput transcriptome profiling.
Externí odkaz:
https://doaj.org/article/7b7edf1cccfe4d95aaa258f27cffc83f
Autor:
Robert J. Ihry, Max R. Salick, Daniel J. Ho, Marie Sondey, Sravya Kommineni, Steven Paula, Joe Raymond, Beata Henry, Elizabeth Frias, Qiong Wang, Kathleen A. Worringer, Chaoyang Ye, Carsten Russ, John S. Reece-Hoyes, Robert C. Altshuler, Ranjit Randhawa, Zinger Yang, Gregory McAllister, Gregory R. Hoffman, Ricardo Dolmetsch, Ajamete Kaykas
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 616-630.e6 (2019)
Summary: Human pluripotent stem cells (hPSCs) generate a variety of disease-relevant cells that can be used to improve the translation of preclinical research. Despite the potential of hPSCs, their use for genetic screening has been limited by techni
Externí odkaz:
https://doaj.org/article/39ad2f3ea8e94904a721c8785edecb36
Autor:
Lichuan Yang, Qingli Shi, Daniel J. Ho, Anatoly A. Starkov, Elizabeth J. Wille, Hui Xu, H.L. Chen, Steven Zhang, Cliona M. Stack, Noel Y. Calingasan, Gary E. Gibson, M. Flint Beal
Publikováno v:
Neurobiology of Disease, Vol 36, Iss 2, Pp 320-330 (2009)
The activity of a key mitochondrial tricarboxylic acid cycle enzyme, α-ketoglutarate dehydrogenase complex (KGDHC), declines in many neurodegenerative diseases. KGDHC consists of three subunits. The dihydrolipoyl succinyl transferase (DLST) componen
Externí odkaz:
https://doaj.org/article/e589e19bf5b940afab0ecdf08e74249c
Autor:
Jingyao Li, Daniel J. Ho, Martin Henault, Chian Yang, Marilisa Neri, Robin Ge, Steffen Renner, Leandra Mansur, Alicia Lindeman, Brian Kelly, Tayfun Tumkaya, Xiaoling Ke, Gilberto Soler-Llavina, Gopi Shanker, Carsten Russ, Marc Hild, Caroline Gubser Keller, Jeremy L. Jenkins, Kathleen A. Worringer, Frederic D. Sigoillot, Robert J. Ihry
Publikováno v:
ACS chemical biology. 17(6)
Unbiased transcriptomic RNA-seq data has provided deep insights into biological processes. However, its impact in drug discovery has been narrow given high costs and low throughput. Proof-of-concept studies with Digital RNA with pertUrbation of Genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84df92c55bb23f5e3de70243ffd28703
https://pubmed.ncbi.nlm.nih.gov/35508359
https://pubmed.ncbi.nlm.nih.gov/35508359
Autor:
Matthew Tegtmeyer, Karrie Chan, Curtis J. Mello, Brant K. Peterson, Daniel J. Ho, Steven A. McCarroll, Jana M. Mitchell, Sulagna Ghosh, Federica Piccioni, Kathleen A. Worringer, Sravya Kommineni, Kavya Raghunathan, Kevin Eggan, Joseph J. Raymond, Michael F. Wells, James Nemesh, Ralda Nehme, Derek C. Hawes, Anna Neumann, Daniel Meyer
SUMMARYVariation in the human genome contributes to abundant diversity in human traits and vulnerabilities, but the underlying molecular and cellular mechanisms are not yet known, and will need scalable approaches to accelerate their recognition. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9cf85eb4e39a5f2090d1f73abd85148
https://doi.org/10.1101/2021.11.08.467815
https://doi.org/10.1101/2021.11.08.467815
Autor:
Kathleen A. Worringer, Robert J. Ihry, Marc Hild, Carsten Russ, Marilisa Neri, Leandra Mansur, Alicia Lindeman, Frederic Sigoillot, Chian Yang, Robin Ge, Jeremy L. Jenkins, Daniel J. Ho, Caroline Gubser Keller, Tayfun Tumkaya, Jingyao Li, Steffen Renner, Martin Henault
Unbiased transcriptomic RNA-seq data has provided deep insights about biological processes. However, its impact in drug discovery has been narrow given high costs and low throughput. Proof-of-concept studies with Digital RNA with pertUrbation of Gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4d7c984cbca815756ba3415d0008b95
https://doi.org/10.1101/2021.06.07.447456
https://doi.org/10.1101/2021.06.07.447456
Autor:
Joseph S. Rabaey, Meredith A. Holgerson, David C. Richardson, Mikkel R. Andersen, Sheel Bansal, Lauren E. Bortolotti, James B. Cotner, Daniel J. Hornbach, Kenneth T. Martinsen, Eric K. Moody, Olivia F. Schloegel
Publikováno v:
Geophysical Research Letters, Vol 51, Iss 15, Pp n/a-n/a (2024)
Abstract Ponds, wetlands, and shallow lakes (collectively “shallow waterbodies”) are among the most biogeochemically active freshwater ecosystems. Measurements of gross primary production (GPP), respiration (R), and net ecosystem production (NEP)
Externí odkaz:
https://doaj.org/article/643e0c4a79104481a906fd311df80d97
Publikováno v:
Animals, Vol 14, Iss 13, p 1967 (2024)
Research into cognition in cats and the impact of nutrition on cat cognitive health lags behind that in dogs but is receiving increased attention. In this review, we discuss the evolutionary history of the domesticated cat, describe possible drivers
Externí odkaz:
https://doaj.org/article/d42baf5cdd5e4475a6e8c02421a58c32
Autor:
ManyDogs Project, Julia Espinosa, Jeffrey R. Stevens, Daniela Alberghina, Harley E. E. Alway, Jessica D. Barela, Michael Bogese, Emily E. Bray, Daphna Buchsbaum, Sarah-Elizabeth Byosiere, Molly Byrne, Camila M. Cavalli, Leah M. Chaudoir, Courtney Collins-Pisano, Hunter J. DeBoer, Laura E. L. C. Douglas, Shany Dror, Marina V. Dzik, Beverly Ferguson, Laura Fisher, Hannah C. Fitzpatrick, Marianne S. Freeman, Shayla N. Frinton, Maeve K. Glover, Gitanjali E. Gnanadesikan, Joshua E. P. Goacher, Marta Golańska, C. N. Alexandrina Guran, Elizabeth Hare, Brian Hare, Mia Hickey, Daniel J. Horschler, Ludwig Huber, Hoi-Lam Jim, Angie M. Johnston, Juliane Kaminski, Debbie M. Kelly, Valerie A. Kuhlmeier, Lily Lassiter, Lucia Lazarowski, Jennifer Leighton-Birch, Evan L. MacLean, Kamila Maliszewska, Vito Marra, Lane I. Montgomery, Madison S. Murray, Emma K. Nelson, Ljerka Ostojić, Shennai G. Palermo, Anya E. Parks Russell, Madeline H. Pelgrim, Sarita D. Pellowe, Anna Reinholz, Laura A. Rial, Emily M. Richards, Miriam A. Ross, Liza G. Rothkoff, Hannah Salomons, Joelle K. Sanger, Laurie Santos, Angelina R. Schirle, Shania J. Shearer, Zachary A. Silver, Jessica M. Silverman, Andrea Sommese, Tiziana Srdoc, Hannah St. John-Mosse, Angelica C. Vega, Kata Vékony, Christoph J. Völter, Carolyn J. Walsh, Yasmin A. Worth, Lena M. I. Zipperling, Bianka Żołędziewska, Sarah G. Zylberfuden
Publikováno v:
Animal Behavior and Cognition, Vol 10, Iss 3, Pp 232-286 (2023)
To promote collaboration across canine science, address replicability issues, and advance open science practices within animal cognition, we have launched the ManyDogs consortium, modeled on similar ManyX projects in other fields. We aimed to create
Externí odkaz:
https://doaj.org/article/17a2d3719f7e4c918b5c7769864af007
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Melatonin (N-acetyl-5-methoxytryptamine) is an indolamine hormone with many physiological and biological roles. Melatonin is an antioxidant, anti-inflammatory, free radical scavenger, circadian rhythm regulator, and sleep hormone. However, its most p
Externí odkaz:
https://doaj.org/article/7dbba42321894b66a406b17eded75fa6