Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Daniel J. Grundy"'
Publikováno v:
Chembiochem
Terpene synthases catalyse the first step in the conversion of prenyl diphosphates to terpenoids. They act as templates for their substrates to generate a reactive conformation, from which a Mg2+‐dependent reaction creates a carbocation–PPi ion p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16b73e1c6cdcc4e2dd6406adc49c6e62
https://pubmed.ncbi.nlm.nih.gov/29802753
https://pubmed.ncbi.nlm.nih.gov/29802753
Autor:
Juan A. Faraldos, Stefano Leoni, Rudolf Konrad Allemann, Oscar Cascón, Daniel J. Grundy, Marc W. van der Kamp
Publikováno v:
Faraldos, J A, Grundy, D J, Cascon, O, Leoni, S, Van der Kamp, M & Allemann, R K 2016, ' Enzymatic synthesis of natural (+)-aristolochene from a non-natural substrate ', Chemical Communications, vol. 52, no. 97, pp. 14027-14030 . https://doi.org/10.1039/C6CC08164A
The sesquiterpene cyclase aristolochene synthase from Penicillium roquefortii (PR-AS) has evolved to catalyse with high specificity (92%) the conversion of farnesyl diphosphate (FDP) to the bicyclic hydrocarbon (+)-aristolochene, the natural precurso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8736a0640154411912fe2c708589bb70
https://hdl.handle.net/1983/bb5d886d-e1b0-4cf1-9765-cae7eaea0092
https://hdl.handle.net/1983/bb5d886d-e1b0-4cf1-9765-cae7eaea0092
Despite its distance from the active site the flexible amino-terminal segment (NTS) in the β-domain of the plant sesquiterpene cyclase δ-cadinene synthase (DCS) is essential for active site closure and desolvation events during catalysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21a70e7e06252fe057a9541faf8e062
https://orca.cardiff.ac.uk/id/eprint/94402/3/Manu-NTS-Final-REV.pdf
https://orca.cardiff.ac.uk/id/eprint/94402/3/Manu-NTS-Final-REV.pdf
Autor:
Daniel J, Grundy, Mengbin, Chen, Verónica, González, Stefano, Leoni, David J, Miller, David W, Christianson, Rudolf K, Allemann
Publikováno v:
Biochemistry
The sesquiterpene synthase germacradiene-4-ol synthase (GdolS) from Streptomyces citricolor is one of only a few known high-fidelity terpene synthases that convert farnesyl diphosphate (FDP) into a single hydroxylated product. Crystals of unliganded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::264c316ad5ca99f2f2be03aeb3c84c38
https://pubmed.ncbi.nlm.nih.gov/26998816
https://pubmed.ncbi.nlm.nih.gov/26998816
Autor:
Rudolf Konrad Allemann, Veronica Gonzalez, Sabrina Touchet, Daniel J. Grundy, Juan A. Faraldos
Germacrene A synthase (GAS) from Solidago canadensis catalyzes the conversion of farnesyl diphosphate (FDP) to the plant sesquiterpene (+)-germacrene A. After diphosphate expulsion, farnesyl cation reacts with the distal 10,11-double bond to afford g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f369dd789d4a43306adfa116b7a8c5
https://orca.cardiff.ac.uk/id/eprint/66255/1/OA-20142015-53.pdf
https://orca.cardiff.ac.uk/id/eprint/66255/1/OA-20142015-53.pdf
Publikováno v:
Biomaterials. 31(29)
The design of self-assembling fibers presents challenges in basic science, and has potential for developing materials for applications in areas such as tissue engineering. A contemporary issue in the field is the construction of multi-component, func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5124cd3b3e94832a32808d9e9c5543af
https://pubmed.ncbi.nlm.nih.gov/20638122
https://pubmed.ncbi.nlm.nih.gov/20638122