Pedunculopontine glutamatergic neurons control spike patterning in substantia nigra dopaminergic neurons

Autor: Daniel J Galtieri, Chad M Estep, David L Wokosin, Stephen Traynelis, D James Surmeier

Publikováno v: eLife, Vol 6 (2017)

Burst spiking in substantia nigra pars compacta (SNc) dopaminergic neurons is a key signaling event in the circuitry controlling goal-directed behavior. It is widely believed that this spiking mode depends upon an interaction between synaptic activat

Externí odkaz: https://doaj.org/article/4560a5b3996748758ac4985a347bc5db

A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of CaV1.3 L-Type Calcium Channels

Autor: Daniel J. Galtieri, Zhong Xie, Soosung Kang, Tamara Perez-Rosello, Richard B. Silverman, Jyothisri Kondapalli, Jaime N. Guzman, D. James Surmeier, Garry Cooper, Jack Mordell

Publikováno v: ACS Chem Biol

Ca(2+) channels with a Ca(V)1.3 pore-forming α(1) subunit have been implicated in both neurodegenerative and neuropsychiatric disorders, motivating the development of selective and potent inhibitors of Ca(V)1.3 vs Ca(V)1.2 channels, the calcium chan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33dfedbe893854b0294388501ad4af10
https://doi.org/10.1021/acschembio.0c00577

The pedunclopontine nucleus and Parkinson's disease

Autor: D. James Surmeier, Daniel J. Galtieri, Cecilia Tubert

Publikováno v: Neurobiol Dis
Neurobiology of Disease, Vol 128, Iss, Pp 3-8 (2019)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

In the last decade, scientific and clinical interest in the pedunculopontine nucleus (PPN) has grown dramatically. This growth is largely a consequence of experimental work demonstrating its connection to the control of gait and of clinical work impl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd0a720cba678c6d37fb5e78263594c
https://www.sciencedirect.com/science/article/pii/S0969996118304935

Pedunculopontine glutamatergic neurons control spike patterning in substantia nigra dopaminergic neurons

Autor: D. James Surmeier, Daniel J. Galtieri, Chad M Estep, David L. Wokosin, Stephen F. Traynelis

Publikováno v: eLife, Vol 6 (2017)
eLife

Burst spiking in substantia nigra pars compacta (SNc) dopaminergic neurons is a key signaling event in the circuitry controlling goal-directed behavior. It is widely believed that this spiking mode depends upon an interaction between synaptic activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e69d93e4d9b2cbcd81289815b3d4902
https://elifesciences.org/articles/30352

Life on the Edge: Determinants of Selective Neuronal Vulnerability in Parkinson’s Disease

Autor: Paul T. Schumacker, Daniel J. Galtieri, James D. Surmeier, Enrico Zampese

Publikováno v: Mitochondrial Dysfunction in Neurodegenerative Disorders ISBN: 9783319286358

One of the defining features of Parkinson’s disease (PD) is its sparsely distributed pathology. This chapter explores the hypothesis that this selective vulnerability can be traced back to an unusual neuronal phenotype. This phenotype is best exemp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6570a1f90ed3f76ad62f8c966ceea036
https://doi.org/10.1007/978-3-319-28637-2_6