Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Daniel J. Deer"'
Autor:
Courtney Woolsey, Robert W. Cross, Abhishek N. Prasad, Krystle N. Agans, Viktoriya Borisevich, Daniel J. Deer, Natalie S. Dobias, Alyssa C. Fears, Mack B. Harrison, Megan L. Heinrich, Karla A. Fenton, Robert F. Garry, Luis M. Branco, Thomas W. Geisbert
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTLassa virus (LASV) is a World Health Organization (WHO) priority pathogen that causes high morbidity and mortality. Recently, we showed that a combination of three broadly neutralizing human monoclonal antibodies known as Arevirumab-3 (8.9F,
Externí odkaz:
https://doaj.org/article/055f26a5860147ff8cc66a9db9b3c6b4
Autor:
Robert W. Cross, Abhishek N. Prasad, Courtney B. Woolsey, Krystle N. Agans, Viktoriya Borisevich, Natalie S. Dobias, Jason E. Comer, Daniel J. Deer, Joan B. Geisbert, Angela L. Rasmussen, Walter Ian Lipkin, Karla A. Fenton, Thomas W. Geisbert
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Transmission of Ebola virus (EBOV) primarily occurs via contact exposure of mucosal surfaces with infected body fluids. Historically, nonhuman primate (NHP) challenge studies have employed intramuscular (i.m.) or small particle aerosol expos
Externí odkaz:
https://doaj.org/article/e50fc8bae44c4bac9ac933f1779af9f9
Autor:
Courtney Woolsey, Alyssa C. Fears, Viktoriya Borisevich, Krystle N. Agans, Natalie S. Dobias, Abhishek N. Prasad, Daniel J. Deer, Joan B. Geisbert, Karla A. Fenton, Thomas W. Geisbert, Robert W. Cross
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1635-1646 (2022)
Due to its high mortality rate and continued re-emergence, Ebolavirus disease (EVD) continues to pose a serious threat to global health. A group of viruses within the genus Ebolavirus causes this severe hemorrhagic disease in humans: Ebola virus (EBO
Externí odkaz:
https://doaj.org/article/4ba14efe32f140fb83a7c614da4e3f7b
Autor:
Robert W. Cross, Christopher M. Wiethoff, Patricia Brown-Augsburger, Shawn Berens, Jamie Blackbourne, Ling Liu, Xiaohua Wu, Jonathan Tetreault, Carter Dodd, Ramtin Sina, Derrick R. Witcher, Deanna Newcomb, Denzil Frost, Angela Wilcox, Viktoriya Borisevich, Krystle N. Agans, Courtney Woolsey, Abhishek N. Prasad, Daniel J. Deer, Joan B. Geisbert, Natalie S. Dobias, Karla A. Fenton, Beth Strifler, Philip Ebert, Richard Higgs, Anne Beall, Sumit Chanda, Laura Riva, Xin Yin, Thomas W. Geisbert
Publikováno v:
Pathogens, Vol 12, Iss 12, p 1408 (2023)
As part of the non-clinical safety package characterizing bamlanivimab (SARS-CoV-2 neutralizing monoclonal antibody), the risk profile for antibody-dependent enhancement of infection (ADE) was evaluated in vitro and in an African green monkey (AGM) m
Externí odkaz:
https://doaj.org/article/f7f4761387234185a8923bd4c6b15ef6
Autor:
Courtney Woolsey, Viktoriya Borisevich, Alyssa C. Fears, Krystle N. Agans, Daniel J. Deer, Abhishek N. Prasad, Rachel O’Toole, Stephanie L. Foster, Natalie S. Dobias, Joan B. Geisbert, Karla A. Fenton, Robert W. Cross, Thomas W. Geisbert
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
The emergence of the novel henipavirus, Langya virus, received global attention after the virus sickened over three dozen people in China. There is heightened concern that henipaviruses, as respiratory pathogens, could spark another pandemic, most no
Externí odkaz:
https://doaj.org/article/6fae00c584d04cfdac053badea1f2c59
Autor:
Robert W. Cross, Zachary A. Bornholdt, Abhishek N. Prasad, Viktoriya Borisevich, Krystle N. Agans, Daniel J. Deer, Dafna M. Abelson, Do H. Kim, William S. Shestowsky, Lioudmila A. Campbell, Elaine Bunyan, Joan B. Geisbert, Karla A. Fenton, Larry Zeitlin, Danielle P. Porter, Thomas W. Geisbert
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Extending the therapeutic window for acute viral infections could save lives. Here, the authors show that combination treatment with a human monoclonal antibody and remdesivir initiated at 6 days post infection with Marburg virus provides 80% protect
Externí odkaz:
https://doaj.org/article/d0f0bff00c684416a81ac789aecee0a8
Autor:
Robert W. Cross, Zachary A. Bornholdt, Abhishek N. Prasad, Courtney Woolsey, Viktoriya Borisevich, Krystle N. Agans, Daniel J. Deer, Dafna M. Abelson, Do H. Kim, William S. Shestowsky, Lioudmila A. Campbell, Elaine Bunyan, Joan B. Geisbert, Natalie S. Dobias, Karla A. Fenton, Danielle P. Porter, Larry Zeitlin, Thomas W. Geisbert
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
A major challenge in managing acute viral infections is ameliorating disease when treatment is delayed. Previously, we reported the success of a 2-pronged mAb and antiviral remdesivir therapeutic approach to treat advanced illness in rhesus monkeys i
Externí odkaz:
https://doaj.org/article/c92d002b9f334e558178cd3717ce240a
Autor:
Robert W. Cross, Krystle N. Agans, Abhishek N. Prasad, Viktoriya Borisevich, Courtney Woolsey, Daniel J. Deer, Natalie S. Dobias, Joan B. Geisbert, Karla A. Fenton, Thomas W. Geisbert
Publikováno v:
Virology Journal, Vol 17, Iss 1, Pp 1-12 (2020)
Abstract We recently reported the development of the first African green monkey (AGM) model for COVID-19 based on a combined liquid intranasal (i.n.) and intratracheal (i.t.) exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). H
Externí odkaz:
https://doaj.org/article/d35178455309467e835c2985b53f471c
Autor:
Robert W. Cross, Zachary A. Bornholdt, Abhishek N. Prasad, Joan B. Geisbert, Viktoriya Borisevich, Krystle N. Agans, Daniel J. Deer, Kevin Melody, Karla A. Fenton, Heinz Feldmann, Armand Sprecher, Larry Zeitlin, Thomas W. Geisbert
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
During an ongoing Ebola virus outbreak, infection before onset of protective immunity from vaccination is a possible scenario. Here the authors show in non-human primates that vaccination shortly before treatment with a monoclonal antibody does not n
Externí odkaz:
https://doaj.org/article/f42ceaff066b4e269cda66de8d4403a1
Autor:
Chad E. Mire, Joan B. Geisbert, Krystle N. Agans, Krista M. Versteeg, Daniel J. Deer, Benjamin A. Satterfield, Karla A. Fenton, Thomas W. Geisbert
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 6, Pp 1144-1152 (2019)
Nipah virus (NiV) is a zoonotic pathogen that causes high case-fatality rates (CFRs) in humans. Two NiV strains have caused outbreaks: the Malaysia strain (NiVM), discovered in 1998–1999 in Malaysia and Singapore (≈40% CFR); and the Bangladesh st
Externí odkaz:
https://doaj.org/article/905c55550047474687afb439b9e77458