Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Daniel J. Bernard"'
Autor:
Sen Qiao, Samer Alasmi, Amanda Wyatt, Philipp Wartenberg, Hongmei Wang, Michael Candlish, Debajyoti Das, Mari Aoki, Ramona Grünewald, Ziyue Zhou, Qinghai Tian, Qiang Yu, Viktoria Götz, Anouar Belkacemi, Ahsan Raza, Fabien Ectors, Kathrin Kattler, Gilles Gasparoni, Jörn Walter, Peter Lipp, Patrice Mollard, Daniel J. Bernard, Ersin Karatayli, Senem Ceren Karatayli, Frank Lammert, Ulrich Boehm
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Gonadotropes in the pituitary secrete follicle-stimulating hormone and luteinizing hormone to control gonadal function and fertility, but whether they exert actions on extra-gonadal organs is not fully understood. Here the authors report that gonadot
Externí odkaz:
https://doaj.org/article/36f657189b3d45d580354e8498eeb1f2
Autor:
Frederique Ruf-Zamojski, Zidong Zhang, Michel Zamojski, Gregory R. Smith, Natalia Mendelev, Hanqing Liu, German Nudelman, Mika Moriwaki, Hanna Pincas, Rosa Gomez Castanon, Venugopalan D. Nair, Nitish Seenarine, Mary Anne S. Amper, Xiang Zhou, Luisina Ongaro, Chirine Toufaily, Gauthier Schang, Joseph R. Nery, Anna Bartlett, Andrew Aldridge, Nimisha Jain, Gwen V. Childs, Olga G. Troyanskaya, Joseph R. Ecker, Judith L. Turgeon, Corrine K. Welt, Daniel J. Bernard, Stuart C. Sealfon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The pituitary gland plays important roles in the regulation of key physiological functions. Here the authors provide a multiomics atlas including transcriptome, chromatin accessibility, and methylation status of over 70,000 single nuclei (sn) from mo
Externí odkaz:
https://doaj.org/article/c782850ef40d4c03ac0d69ac797d06d6
Autor:
Zidong Zhang, Michel Zamojski, Gregory R. Smith, Thea L. Willis, Val Yianni, Natalia Mendelev, Hanna Pincas, Nitish Seenarine, Mary Anne S. Amper, Mital Vasoya, Wan Sze Cheng, Elena Zaslavsky, Venugopalan D. Nair, Judith L. Turgeon, Daniel J. Bernard, Olga G. Troyanskaya, Cynthia L. Andoniadou, Stuart C. Sealfon, Frederique Ruf-Zamojski
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110467- (2022)
Summary: Despite their importance in tissue homeostasis and renewal, human pituitary stem cells (PSCs) are incompletely characterized. We describe a human single nucleus RNA-seq and ATAC-seq resource from pediatric, adult, and aged postmortem pituita
Externí odkaz:
https://doaj.org/article/9778f6fbae6c4b3ebc1fa18a2a9f30e3
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Immunoglobulin superfamily, member 1 (IGSF1) is a transmembrane glycoprotein with high expression in the mammalian pituitary gland. Mutations in the IGSF1 gene cause congenital central hypothyroidism in humans. The IGSF1 protein is co-translationally
Externí odkaz:
https://doaj.org/article/a3c88e44bce24d6bb825da97b93c3eeb
Autor:
Emilie Brûlé, Xiang Zhou, Ying Wang, Evan R S Buddle, Luisina Ongaro, Mary Loka, Anita Boelen, Daniel J Bernard
Publikováno v:
European Thyroid Journal, Vol 13, Iss 1, Pp 1-9 (2024)
Objective: Loss of function mutations in the insulin receptor substrate 4 (IRS4) gene cause a rare form of X-linked congenital central hypothyroidism in boys and men. Affected individuals show decreased thyroid-stimulating hormone (TSH) secretion. Me
Externí odkaz:
https://doaj.org/article/4bb5a921b517487bbde883bb9523a9d5
Autor:
Erich J Goebel, Luisina Ongaro, Emily C Kappes, Kylie Vestal, Elitza Belcheva, Roselyne Castonguay, Ravindra Kumar, Daniel J Bernard, Thomas B Thompson
Publikováno v:
eLife, Vol 11 (2022)
Activin ligands are formed from two disulfide-linked inhibin β (Inhβ) subunit chains. They exist as homodimeric proteins, as in the case of activin A (ActA; InhβA/InhβA) or activin C (ActC; InhβC/InhβC), or as heterodimers, as with activin AC (
Externí odkaz:
https://doaj.org/article/45502bd4407a4075bf81ff99f93c4015
Autor:
Chirine Toufaily, Jérôme Fortin, Carlos AI Alonso, Evelyne Lapointe, Xiang Zhou, Yorgui Santiago-Andres, Yeu-Farn Lin, Yiming Cui, Ying Wang, Dominic Devost, Ferdinand Roelfsema, Frederik Steyn, Aylin C Hanyaloglu, Terence E Hébert, Tatiana Fiordelisio, Derek Boerboom, Daniel J Bernard
Publikováno v:
eLife, Vol 10 (2021)
Gonadotropin-releasing hormone (GnRH) is the primary neuropeptide controlling reproduction in vertebrates. GnRH stimulates follicle-stimulating hormone (FSH) and luteinizing hormone (LH) synthesis via a G-protein-coupled receptor, GnRHR, in the pitui
Externí odkaz:
https://doaj.org/article/67a8eb78b0ce46eab129601c15478f79
Autor:
Daniel J Bernard
Publikováno v:
Endocrine Abstracts.
Autor:
Carlos A I Alonso, Caroline D David, Chirine Toufaily, Ying Wang, Xiang Zhou, Luisina Ongaro, German Nudelman, Venugopalan D Nair, Frederique Ruf-Zamojski, Ulrich Boehm, Stuart C Sealfon, Daniel J Bernard
Publikováno v:
Endocrinology. 164
Follicle-stimulating hormone (FSH), a dimeric glycoprotein produced by pituitary gonadotrope cells, regulates spermatogenesis in males and ovarian follicle growth in females. Hypothalamic gonadotropin-releasing hormone (GnRH) stimulates FSHβ subunit
Autor:
Emily C Kappes, Chandramohan Kattamuri, Magdalena Czepnik, Alexander E Yarawsky, Emilie Brûlé, Ying Wang, Luisina Ongaro, Andrew B Herr, Kelly L Walton, Daniel J Bernard, Thomas B Thompson
Publikováno v:
Endocrinology
Inhibins are transforming growth factor-β family heterodimers that suppress follicle-stimulating hormone (FSH) secretion by antagonizing activin class ligands. Inhibins share a common β chain with activin ligands. Follistatin is another activin ant