Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Daniel J. Atwood"'
Autor:
Ozgur A. Oto, Daniel J. Atwood, Anjana Chaudhary, Zhibin He, Amy S. Li, Michael F. Wempe, Charles L. Edelstein
Publikováno v:
Physiological Reports, Vol 11, Iss 17, Pp n/a-n/a (2023)
Abstract Metformin (MET) has the potential to activate p‐AMPK and block mTORC1‐induced proliferation of tubular cells in PKD kidneys. The aim of this study was to determine the effects of MET on cyst growth, kidney function, AMPK and mTOR signali
Externí odkaz:
https://doaj.org/article/37f78461b061403ab45d555a577cbf8f
Autor:
Ryan C. Hill, Daniel J. Atwood, Andrew M. Lombardi, Deepak Pokhrel, Katharina Hopp, Carolyn N. Brown, Sara E Brown, Khoa N. Nguyen, Charles L. Edelstein, Mary C.M. Weiser-Evans, Miguel A. Lanaspa, Sara J. Holditch
Publikováno v:
Hum Mol Genet
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease, characterized by cyst formation and growth. Hyperproliferation is a major contributor to cyst growth. At the nexus of regulating proliferation, is 4E-BP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54eddd93f6b9e7697ba0e0d56ce94e0b
https://doi.org/10.1093/hmg/ddz244
https://doi.org/10.1093/hmg/ddz244
Autor:
Charles L. Edelstein, Khoa N. Nguyen, Daniel J. Atwood, Sara J. Holditch, Andrew M. Lombardi, Carolyn N. Brown, Harrison W. Toll, Katharina Hopp
Publikováno v:
American Journal of Physiology-Renal Physiology. 317:F187-F196
Autosomal dominant polycystic kidney disease (PKD) is characterized by cyst formation and growth, which are partially driven by abnormal proliferation of tubular cells. Proproliferative mechanistic target of rapamycin (mTOR) complexes 1 and 2 (mTORC1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a36bfb153ea5ecf809f17850c4fbe46e
https://doi.org/10.1152/ajprenal.00051.2019
https://doi.org/10.1152/ajprenal.00051.2019
Autor:
Carolyn N. Brown, Charles L. Edelstein, Daniel J. Atwood, Christopher Altmann, Sarah Faubel, Andrew Thorburn, Nataliya I. Skrypnyk, Sara J. Holditch, Judith Blaine, Jelena Klawitter, Jennifer N. Bourne, Deepak Pokhrel
Publikováno v:
Cell Death and Disease, Vol 12, Iss 3, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Many surgical models are used to study kidney and other diseases in mice, yet the effects of the surgical procedure itself on the kidney and other tissues have not been elucidated. In the present study, we found that both sham surgery and unilateral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e31818e45b6f5983555b94e7cfa9d9
https://doi.org/10.1038/s41419-021-03518-w
https://doi.org/10.1038/s41419-021-03518-w
Autor:
Deepak Pokhrel, Andrew Thorburn, Sara J. Holditch, Charles L. Edelstein, Katharina Hopp, Daniel J. Atwood, Dheevena M. Bachu, Carolyn N. Brown
Publikováno v:
Cellular signalling. 74
Cardiac hypertrophy is common in autosomal dominant polycystic kidney disease (ADPKD) patients. We found increased heart weight in Pkd1RC/RC and Pkd2WS25/+ mouse models of ADPKD. As there is a link between increased heart weight and mammalian target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810e1fe73edd06925cc9446763c8b6c3
https://pubmed.ncbi.nlm.nih.gov/32730856
https://pubmed.ncbi.nlm.nih.gov/32730856
Autor:
Sanskriti Saxena, Kameswaran Ravichandran, Carolyn N. Brown, Mary C.M. Weiser-Evans, Danica Galešić Ljubanović, Deepak Pokhrel, Melanie S. Joy, Raphael A. Nemenoff, Charles L. Edelstein, Daniel J. Atwood, Sara J. Holditch, Makoto Miyazaki
Publikováno v:
Cell Signal
In a clinically-relevant model of 4 week, low-dose cisplatin-induced AKI, mice were injected subcutaneously with non small cell lung cancer (NSCLC) cells that harbor an activating Kirsten rat sarcoma viral oncogene homolog (KRAS)G12V mutation. Phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8a28b7ee4b0487d6d2f77ac7214199
https://doi.org/10.1016/j.cellsig.2020.109605
https://doi.org/10.1016/j.cellsig.2020.109605
Autor:
Sara J, Holditch, Carolyn N, Brown, Daniel J, Atwood, Andrew M, Lombardi, Khoa N, Nguyen, Harrison W, Toll, Katharina, Hopp, Charles L, Edelstein
Publikováno v:
Am J Physiol Renal Physiol
Autosomal dominant polycystic kidney disease (PKD) is characterized by cyst formation and growth, which are partially driven by abnormal proliferation of tubular cells. Proproliferative mechanistic target of rapamycin (mTOR) complexes 1 and 2 (mTORC1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c7a178fd449de63b456e0fa3a1cb73d
https://pubmed.ncbi.nlm.nih.gov/31042058
https://pubmed.ncbi.nlm.nih.gov/31042058
Autor:
Daniel J. Atwood, Andrew Thorburn, Carolyn N. Brown, Katharina Hopp, Charles L. Edelstein, Sara J. Holditch, Deepak Pokhrel
Publikováno v:
Cellular Signalling. 75:109760
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder characterized by kidney cyst growth often resulting in end-stage renal disease. There is growing attention on understanding the role of impaired autophagy in ADPKD. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde2ab09f76b2643d3b5a25570cb468c
https://doi.org/10.1016/j.cellsig.2020.109760
https://doi.org/10.1016/j.cellsig.2020.109760