Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer’s disease

Autor: Stuart M. Allan, J Scott Miners, Daniel J. Asby, Seth Love, Delphine Boche

Publikováno v: Brain
Asby, D, Boche, D, Allan, S, Love, S & Miners, J S 2021, ' Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer's disease ', Brain, vol. 144, no. 6, pp. 1869-1883 . https://doi.org/10.1093/brain/awab094

See Huuskonen et al. (doi:10.1093/brain/awab168) for a scientific commentary on this article. Systemic infection exacerbates Alzheimer’s disease. In this postmortem study, Asby et al. provide evidence that it does so by raising the levels of multip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caeba3f37bca895d276b2985a04358d9
http://europepmc.org/articles/PMC8320299

Combined use of CDK4/6 and mTOR inhibitors induce synergistic growth arrest of diffuse intrinsic pontine glioma cells via mutual downregulation of mTORC1 activity

Autor: Neil U Barua, Lisa J. Boulter, Steven S Gill, Daniel J. Asby, Alison Bienemann, Claire Asby, Marcella J Wyatt, Clare L Killick-Cole, William G B Singleton

Publikováno v: Asby, D, Killick-Cole, C, Boulter, L, Singleton, W, Asby, C, Wyatt, M, Barua, N, Bienemann, A & Gill, S 2018, ' Combined use of CDK4/6 and mTOR inhibitors induce synergistic growth arrest of diffuse intrinsic pontine glioma cells via mutual downregulation of mTORC1 activity ', Cancer Management and Research, vol. 10, pp. 3483-3500 . https://doi.org/10.2147/CMAR.S167095

Daniel J Asby,1 Clare L Killick-Cole,1 Lisa J Boulter,1 William GB Singleton,1,2 Claire A Asby,3 Marcella J Wyatt,1 Neil U Barua,1,2 Alison S Bienemann,1 Steven S Gill1,2 1Functional Neurosurgery Research Group, Translational Health Sciences, Bristol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdb65448a5314dd7979fcf12de3c849
https://www.dovepress.com/combined-use-of-cdk46-and-mtor-inhibitors-induce-synergistic-growth-ar-peer-reviewed-article-CMAR

TRTH-19. PRECLINICAL ANALYSIS OF SODIUM VALPROATE FOR THE TREATMENT OF DIPG BY CONVECTION ENHANCED DELIVERY

Autor: Clare L Killick-Cole, Marcella J Wyatt, A.S. Bienemann, Daniel J. Asby, William G B Singleton, Lisa J. Boulter, Neil U Barua, Steven S. Gill

There is a significant need to develop new treatment strategies to improve the prognosis of DIPG patients. We have previously shown that the HDAC inhibitor, sodium valproate (VPA), reduces the viability of DIPG cells in vitro. Whilst, VPA does cross

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d585b0f3a3e652a5e6b37ac61c8c44
https://europepmc.org/articles/PMC5475205/

Stereocontrol by Quaternary Centres: A Stereoselective Synthesis of (−)-Luminacin D

Autor: Daniel J. Asby, Matthew D. Selby, Ali Tavassoli, Bruno Linclau, Leona J. Gross, Florent Peron, Nathan Bartlett

Publikováno v: Chemistry - A European Journal. 20:3306-3310

Very high diastereoselectivity can be achieved by 1,3-chelation-controlled allylation of aldehydes that possess a non-chelating α-ether substituent, even if the α-position is a quaternary centre and/or a spiro-epoxide. This reaction was used as a k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6aa94167fc77d36c53fe88afbb1252
https://doi.org/10.1002/chem.201304776

Perenosins: a new class of anion transporter with anti-cancer activity

Autor: Ali Tavassoli, Philip A. Gale, Daniel J. Asby, Wim Van Rossom

Publikováno v: Organicbiomolecular chemistry. 14(9)

A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794f1939f8cac587860a6416b8ff4362
https://pubmed.ncbi.nlm.nih.gov/26905059