Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Daniel J Roberts"'
Autor:
Stephen D. Dertinger, Dingzhou Li, Carol Beevers, George R. Douglas, Robert H. Heflich, David P. Lovell, Daniel J. Roberts, Robert Smith, Yoshifumi Uno, Andrew Williams, Kristine L. Witt, Andreas Zeller, Changhui Zhou
Publikováno v:
Environmental and Molecular Mutagenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98ed77f417ad4664c6907cb385e09df2
https://doi.org/10.1002/em.22541
https://doi.org/10.1002/em.22541
Autor:
Nikolai Chepelev, Alexandra S. Long, Marc Beal, Tara Barton‐Maclaren, George Johnson, Kerry L. Dearfield, Daniel J. Roberts, Jan van Benthem, Paul White
Quantitative relationships between carcinogenic potency and mutagenic potency have been previously examined using a benchmark dose (BMD)-based approach. We extended those analyses by using human exposure data for 48 compounds to calculate carcinogeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec5f7d5e1443e48322025cbee9a0143
https://cronfa.swan.ac.uk/Record/cronfa62130/Download/62130__26212__b5e6e4c6d8ed456f8c5505a0ef5d6079.pdf
https://cronfa.swan.ac.uk/Record/cronfa62130/Download/62130__26212__b5e6e4c6d8ed456f8c5505a0ef5d6079.pdf
Autor:
Eunnara Cho, Ashley Allemang, Marc Audebert, Vinita Chauhan, Stephen Dertinger, Giel Hendriks, Mirjam Luijten, Francesco Marchetti, Sheroy Minocherhomji, Stefan Pfuhler, Daniel J. Roberts, Kristina Trenz, Carole L. Yauk
Publikováno v:
Environmental and molecular mutagenesis. 63(3)
The Genetic Toxicology Technical Committee (GTTC) of the Health and Environmental Sciences Institute (HESI) is developing adverse outcome pathways (AOPs) that describe modes of action leading to potentially heritable genomic damage. The goal was to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31bcf3d293d3e20b55c24947b6967ef
https://pubmed.ncbi.nlm.nih.gov/35315142
https://pubmed.ncbi.nlm.nih.gov/35315142
Autor:
Robert H. Heflich, Takafumi Kimoto, David P. Lovell, Daniel J Roberts, Stephen D. Dertinger, Leon F. Stankowski, Daishiro Miura, B. Bhaskar Gollapudi, Javed A. Bhalli, Leslie Recio
Publikováno v:
Environmental and Molecular Mutagenesis
The rodent Pig‐a assay is a flow cytometric, phenotype‐based method used to measure in vivo somatic cell mutation. An Organization for Economic Co‐operation and Development (OECD) test guideline is currently being developed to support routine u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f979d14c500f49c002289aed7729062
https://pubmed.ncbi.nlm.nih.gov/33608913
https://pubmed.ncbi.nlm.nih.gov/33608913
Autor:
Tiefu Shen, Brittany T Watkins, Frank D Groves, Thomas C. Tucker, Timothy J Flood, Daniel J Roberts
Publikováno v:
Southern Medical Journal. 111:579-584
Objective To confirm the previously reported increased risk of leukemia among macrosomic children (those with birth weight >4 kg). Methods Birth certificates of Arizona, Illinois, and Kentucky children diagnosed as having acute lymphoblastic leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b95f8defc8774f215beabeebcd67c6ab
https://doi.org/10.14423/smj.0000000000000873
https://doi.org/10.14423/smj.0000000000000873
Autor:
Svetlana L. Avlasevich, Demetria Thomas, Cameron C. Tebbe, Brett Schneider, Mary Richardson, Matthew Barragato, B. Bhaskar Gollapudi, Dorothea K. Torous, Daniel J. Roberts, John Prattico, Jessica Noteboom, Stephen D. Dertinger, Jeffrey C. Bemis, Javed A. Bhalli
Publikováno v:
Environmental and Molecular Mutagenesis. 60:47-55
The rodent blood Pig-a assay has been undergoing international validation for use as an in vivo hematopoietic cell gene mutation assay, and given the promising results an Organization for Economic Co-operation and Development (OECD) Test Guideline is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fdd5ea96e6a730c7d9e1e662dcac020
https://doi.org/10.1002/em.22249
https://doi.org/10.1002/em.22249
Autor:
Daniel J Roberts, Azra Dad, Javier R. Revollo, Dayton M. Petibone, Mason G. Pearce, Vasily N. Dobrovolsky, Timothy W. Robison
Publikováno v:
Environmental and Molecular Mutagenesis. 59:722-732
We have established a flow cytometry-based Pig-a assay for rat bone marrow erythroid cells (BMEs). The BME Pig-a assay uses a DNA-specific stain and two antibodies: one against the transmembrane transferrin receptor (CD71 marker) and the other agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07e28bbd35e53512dcab35615b581ff4
https://doi.org/10.1002/em.22211
https://doi.org/10.1002/em.22211
Autor:
Steven M. Bryce, Laura Custer, Kerry L. Dearfield, Carole L. Yauk, Giel Hendriks, Ashley Allemang, Sheila M. Galloway, Maik Schuler, Stefan Pfuhler, Patricia A Escobar, Azeddine Elhajouji, Gladys Ouedraogo, Albert J. Fornace, Heng-Hong Li, Jennifer C. Sasaki, Daniel J Roberts, Yasmin Dietz, Ulrike Hemmann, Jan van Benthem, Véronique Thybaud, Roland Froetschl, Lauren Peel, Mirjam Luijten
In May 2017, the Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee hosted a workshop to discuss whether mode of action (MOA) investigation is enhanced through the application of the adverse outcome pathway (AOP) fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94120698a05b8acf2acfae209b20a2b1
http://hdl.handle.net/10029/623463
http://hdl.handle.net/10029/623463
Autor:
Véronique Thybaud, Christopher S Farabaugh, Frank Le Curieux, John Nicolette, Javed A. Bhalli, Melanie Guérard, Marilyn J. Aardema, George R. Douglas, David P. Lovell, Leon F. Stankowski, George E. Johnson, Andrew Williams, Mirjam Luijten, Sandy Weiner, Kristine L. Witt, Carol Beevers, Jasmin Lott, Francesco Marchetti, Patricia A. Escobar, Alexandra S. Long, Daniel J Roberts, Robert R. Young, David Kirkland, Rohan Kulkarni, Stefan Pfuhler, Matthew J. LeBaron, Dan D. Levy
A database of 91 chemicals with published data from both transgenic rodent mutation (TGR) and rodent comet assays has been compiled. The objective was to compare the sensitivity of the two assays for detecting genotoxicity. Critical aspects of study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5685a1dd3e8efa3d80cab9943695dcf
https://openaccess.sgul.ac.uk/id/eprint/110683/1/1-s2.0-S1383571818304169-main.pdf
https://openaccess.sgul.ac.uk/id/eprint/110683/1/1-s2.0-S1383571818304169-main.pdf
Publikováno v:
Environmental and Molecular Mutagenesis. 57:17-27
During interlaboratory validation trials for the Pig-a gene mutation assay we assessed the genotoxicity of 4-nitroquinoline-1-oxide (4NQO) across endpoints in multiple tissues: induction of Pig-a mutant red blood cells (RBCs) and reticulocytes (RETs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::458e70de72201973205045d86524fc0e
https://doi.org/10.1002/em.21981
https://doi.org/10.1002/em.21981