Zobrazeno 1 - 10
of 302
pro vyhledávání: '"Daniel J Rigden"'
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0220754 (2020)
IntroductionAdverse drug reactions have been linked with HLA alleles in different studies. These HLA proteins play an essential role in the adaptive immune response for the presentation of self and non-self peptides. Anti-thyroid drugs methimazole an
Externí odkaz:
https://doaj.org/article/d9638b62b60e4f18b4e1aeb9e880ca1d
Autor:
Quentin M Nunes, Dunhao Su, Philip J Brownridge, Deborah M Simpson, Changye Sun, Yong Li, Thao P Bui, Xiaoying Zhang, Wei Huang, Daniel J Rigden, Robert J Beynon, Robert Sutton, David G Fernig
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0217633 (2019)
Acute pancreatitis (AP) is acute inflammation of the pancreas, mainly caused by gallstones and alcohol, driven by changes in communication between cells. Heparin-binding proteins (HBPs) play a central role in health and diseases. Therefore, we used h
Externí odkaz:
https://doaj.org/article/42f521e277b448e89cb95674604e666f
Autor:
Filomeno Sánchez Rodríguez, Adam J. Simpkin, Grzegorz Chojnowski, Ronan M. Keegan, Daniel J. Rigden
Publikováno v:
IUCrJ, Vol 11, Iss 6, Pp 938-950 (2024)
The accuracy of the information in the Protein Data Bank (PDB) is of great importance for the myriad downstream applications that make use of protein structural information. Despite best efforts, the occasional introduction of errors is inevitable, e
Externí odkaz:
https://doaj.org/article/5e6b06cec2dd4c3b99bbba3590a1c3f6
Autor:
Ana Brennand, Eva Rico, Daniel J Rigden, Patrick Van Der Smissen, Pierre J Courtoy, Paul A M Michels
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130365 (2015)
We have previously identified homologs for nearly half of the approximately 30 known yeast Atg's in the genome database of the human sleeping sickness parasite Trypanosoma brucei. So far, only a few of these homologs have their role in autophagy expe
Externí odkaz:
https://doaj.org/article/ff22d48921f949e789c164470e9f6d98
Autor:
Rong Xia, Xiangyu Yin, Jiaming Huang, Kunqi Chen, Jiongming Ma, Zhen Wei, Jionglong Su, Neil Blake, Daniel J. Rigden, Jia Meng, Bowen Song
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102376- (2024)
Cancer is a complex and multifaceted group of diseases characterized by uncontrolled cell growth that leads to the formation of malignant tumors. Recent studies suggest that N6-methyladenosine (m6A) RNA methylation plays pivotal roles in cancer patho
Externí odkaz:
https://doaj.org/article/da176ee8742f429abfdbe1de4a69633b
Autor:
Sara N Mitchell, Daniel J Rigden, Andrew J Dowd, Fang Lu, Craig S Wilding, David Weetman, Samuel Dadzie, Adam M Jenkins, Kimberly Regna, Pelagie Boko, Luc Djogbenou, Marc A T Muskavitch, Hilary Ranson, Mark J I Paine, Olga Mayans, Martin J Donnelly
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92662 (2014)
The development of resistance to insecticides has become a classic exemplar of evolution occurring within human time scales. In this study we demonstrate how resistance to DDT in the major African malaria vector Anopheles gambiae is a result of both
Externí odkaz:
https://doaj.org/article/dbee75b9f6e1498c894fa8f58f3b00b3
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103026 (2014)
Classically viewed as a cytosolic pathway, glycolysis is increasingly recognized as a metabolic pathway exhibiting surprisingly wide-ranging variations in compartmentalization within eukaryotic cells. Trypanosomatid parasites provide an extreme view
Externí odkaz:
https://doaj.org/article/06c965b9b5394303b32c7c1d6788a3e4
Autor:
Daniel J Rigden, Qingping Xu, Yuanyuan Chang, Ruth Y Eberhardt, Robert D Finn, Neil D Rawlings
Publikováno v:
F1000Research, Vol 2 (2013)
We report the crystal structure solution of the Intracellular Protease Inhibitor (IPI) protein from Bacillus subtilis, which has been reported to be an inhibitor of the intracellular subtilisin Isp1 from the same organism. The structure of IPI is a v
Externí odkaz:
https://doaj.org/article/02c05be0a31e4a3c9482a0ff912c3a51
Publikováno v:
PLoS ONE, Vol 8, Iss 2 (2013)
[This corrects the article DOI: 10.1371/journal.pone.0044879.].
Externí odkaz:
https://doaj.org/article/666ca942461f475dba0259de40318dec
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44879 (2012)
Caveolins are coat proteins of caveolae, small flask-shaped pits of the plasma membranes of most cells. Aside from roles in caveolae formation, caveolins recruit, retain and regulate many caveolae-associated signalling molecules. Caveolin-protein int
Externí odkaz:
https://doaj.org/article/a0e1933e0e814d0da8b2894c6552fc30