Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Daniel J Pennington"'
Autor:
Claudia P Cabrera, Joanna Manson, Joanna M Shepherd, Hew D Torrance, David Watson, M Paula Longhi, Mimoza Hoti, Minal B Patel, Michael O'Dwyer, Sussan Nourshargh, Daniel J Pennington, Michael R Barnes, Karim Brohi
Publikováno v:
PLoS Medicine, Vol 15, Iss 10, p e1002694 (2018)
[This corrects the article DOI: 10.1371/journal.pmed.1002352.].
Externí odkaz:
https://doaj.org/article/61e2b804978145a38aa7b03ae88490e9
Autor:
Claudia P Cabrera, Joanna Manson, Joanna M Shepherd, Hew D Torrance, David Watson, M Paula Longhi, Mimoza Hoti, Minal B Patel, Michael O'Dwyer, Sussan Nourshargh, Daniel J Pennington, Michael R Barnes, Karim Brohi
Publikováno v:
PLoS Medicine, Vol 14, Iss 7, p e1002352 (2017)
BackgroundSevere trauma induces a widespread response of the immune system. This "genomic storm" can lead to poor outcomes, including Multiple Organ Dysfunction Syndrome (MODS). MODS carries a high mortality and morbidity rate and adversely affects l
Externí odkaz:
https://doaj.org/article/3f0abdb9e3cd47acb82ce46235ff8606
Autor:
Karoline Fechter, Akaitz Dorronsoro, Emma Jakobsson, Izaskun Ferrin, Valérie Lang, Pilar Sepulveda, Daniel J Pennington, César Trigueros
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169362 (2017)
γδ T cells play a role in a wide range of diseases such as autoimmunity and cancer. The majority of circulating human γδ T lymphocytes express a Vγ9Vδ2+ (Vδ2+) T cell receptor (TCR) and following activation release pro-inflammatory cytokines.
Externí odkaz:
https://doaj.org/article/801e592cab1f4c2a95beb4f8aba11376
Autor:
Stephen Murtough, Deepak Babu, Catherine M. Webb, Hélène Louis dit Picard, Lisa A. McGinty, Jennifer Chao-Chu, Ryan Pink, Andrew R. Silver, Howard L. Smart, John K. Field, Philip Woodland, Janet M. Risk, Diana C. Blaydon, Daniel J. Pennington, David P. Kelsell
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 3, Pp 385-395 (2024)
Background and Aims: Survival rates for esophageal squamous cell carcinoma (ESCC) are extremely low due to the late diagnosis of most cases. An understanding of the early molecular processes that lead to ESCC may facilitate opportunities for early di
Externí odkaz:
https://doaj.org/article/a85cc09e91124fee910a8d340d8707ab
Autor:
Marta Sanz, Brendan T. Mann, Paul L. Ryan, Alberto Bosque, Daniel J. Pennington, Holger Hackstein, Natalia Soriano-Sarabia
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Under non-pathological conditions, human γδ T cells represent a small fraction of CD3+ T cells in peripheral blood (1-10%). They constitute a unique subset of T lymphocytes that recognize stress ligands or non-peptide antigens through MHC-independe
Externí odkaz:
https://doaj.org/article/9fed376318a4488d8eed264cc84fc1bb
Autor:
Priyanka Hirani, Kimberly M. Alonge, Daniel J. Pennington, Pedro R. Cutillas, Thomas N. Wight, Oliver M. Pearce
Publikováno v:
Cancer Research. 83:5841-5841
Immunotherapy has found limited success in solid tumors such as triple negative breast cancer (TNBC). The poor response can be attributed to the presence of the extracellular matrix (ECM) that can act biochemically or physically to interfere with cyt
Autor:
Ser Sue Ng, SoFong Cam Ngan, Gnanasekaran JebaMercy, Wei Meng, Xue Guo, Jung Eun Park, Dominique de Kleijn, Kalailingam Pazhanchamy, Siu Kwan Sze, Vitaly Sorokin, Daniel J. Pennington, A. Mark Richards, Ken Cheng Kang Liou, Neil E. McCarthy, Hee Hwa Ho, Melvin Khee-Shing Leow, Soe EinSi Lynn, Su Chi Lim
Publikováno v:
Atherosclerosis. 324:58-68
Background and aims: Aging is the primary risk factor for cardiovascular disease (CVD), but the mechanisms underlying age-linked atherosclerosis remain unclear. We previously observed that long-lived vascular matrix proteins can acquire 'gain-of-func
Publikováno v:
Frontiers in Genetics. 13
The assessment of the cellular heterogeneity and abundance in bulk tissue samples is essential for characterising cellular and organismal states. Computational approaches to estimate cellular abundance from bulk RNA-Seq datasets have variable perform
Autor:
N. Zaman, S.L.M. Walker, Keat-Eng Ng, Joseph Westaby, G. Mastroianni, Ryan C. Pink, S. Murtough, Paul J. Delaney, D. Thenet, Elena Tsisanova, Daniel J. Pennington, C.M. Webb, Andrew Tinker, David P. Kelsell
Publikováno v:
Cell and Tissue Research
The study of a desmoglein 2 murine model of arrhythmogenic cardiomyopathy revealed cardiac inflammation as a key early event leading to fibrosis. Arrhythmogenic cardiomyopathy (AC) is an inherited heart muscle disorder leading to ventricular arrhythm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac543c2bf4bb7d609238d5df700e92a
https://openaccess.sgul.ac.uk/id/eprint/113449/35/Ng2021_Article_EarlyInflammationPrecedesCardi.pdf
https://openaccess.sgul.ac.uk/id/eprint/113449/35/Ng2021_Article_EarlyInflammationPrecedesCardi.pdf
Publikováno v:
Science Signaling. 14
Murine γδ17 cells, which are T cells that bear the γδ T cell receptor (TCRγδ) and secrete interleukin-17A (IL-17A), are generated in the thymus and are critical for various immune responses. Although strong TCRγδ signals are required for the