Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Daniel J Lodge"'
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0232200 (2020)
Schizophrenia is a debilitating disorder affecting just under 1% of the population. While the symptoms of this disorder do not appear until late adolescence, pathological alterations likely occur earlier, during development in utero. While there is a
Externí odkaz:
https://doaj.org/article/366b584898644c75b6a035c42249e47f
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract People with schizophrenia show hyperactivity in the ventral hippocampus (vHipp) and we have previously demonstrated distinct behavioral roles for vHipp cell populations. Here, we test the hypothesis that parvalbumin (PV) and somatostatin (SS
Externí odkaz:
https://doaj.org/article/9cb46bcbd8d64c4d93b79eae514b9fce
Autor:
Stephanie M. Perez, Alexandra M. McCoy, Thomas D. Prevot, Md Yeunus Mian, Flavia R. Carreno, Alan Frazer, James M. Cook, Etienne Sibille, Daniel J. Lodge
Publikováno v:
Biological Psychiatry Global Open Science, Vol 3, Iss 1, Pp 78-86 (2023)
Background: Aberrant dopamine neuron activity is attributable to hyperactivity in hippocampal subfields driving a pathological increase in dopamine neuron activity, which is positively correlated with psychosis in humans. Evidence indicates that hipp
Externí odkaz:
https://doaj.org/article/084ff4c6137d42009c20604b31e46173
Autor:
Nicole E. Eassa, Stephanie M. Perez, Angela M. Boley, Hannah B. Elam, Dishary Sharmin, James M. Cook, Daniel J. Lodge
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11788 (2023)
Of the 35 million people in the world suffering from Alzheimer’s Disease (AD), up to half experience comorbid psychosis. Antipsychotics, used to treat psychosis, are contraindicated in elderly patients because they increase the risk of premature de
Externí odkaz:
https://doaj.org/article/86f2d1d11a914dcd8372a503eeba27c9
Autor:
Alexandra M. McCoy, Thomas D. Prevot, Dishary Sharmin, James M. Cook, Etienne L. Sibille, Daniel J. Lodge
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11588 (2023)
Although seizures are a hallmark feature of temporal lobe epilepsy (TLE), psychiatric comorbidities, including psychosis, are frequently associated with TLE and contribute to decreased quality of life. Currently, there are no defined therapeutic prot
Externí odkaz:
https://doaj.org/article/5431d54356ae4830ad503389385e3291
Autor:
Vanesa Nieto-Estévez, Jennifer J. Donegan, Courtney L. McMahon, Hannah B. Elam, Teresa A. Chavera, Parul Varma, Kelly A. Berg, Daniel J. Lodge, Jenny Hsieh
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
The misuse of opioids has reached epidemic proportions over the last decade, with over 2.1 million people in the United States suffering from substance use disorders related to prescription opioid pain relievers. This increase in opioid misuse affect
Externí odkaz:
https://doaj.org/article/5d598ba3976948a182a2ad66fbdf3076
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Post-traumatic stress disorder (PTSD) is a prevalent condition affecting approximately 8% of the United States population and 20% of United States combat veterans. In addition to core symptoms of the disorder, up to 64% of individuals diagno
Externí odkaz:
https://doaj.org/article/98cbb80306624c4e97396c531721d1e7
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7196 (2023)
Antipsychotics increase the risk of death in elderly patients with Alzheimer’s disease (AD). Thus, there is an immediate need for novel therapies to treat comorbid psychosis in AD. Psychosis has been attributed to a dysregulation of the dopamine sy
Externí odkaz:
https://doaj.org/article/ff527e54049240c5a08f2ec03f5e3661
Autor:
Ameet S. Nagpal, Daniel J. Lodge, Jennifer S. Potter, Alan Frazer, Robin Tragus, Megan E. Curtis, Angela M. Boley, Maxim Eckmann
Publikováno v:
Frontiers in Pain Research, Vol 3 (2022)
Background and ObjectivesPatients taking opioids are at risk of developing dependence and possibly abuse. Given the role of the mesolimbic dopamine system in opioid reward, blocking dopamine D2 receptors should limit the abuse liability of opioid ana
Externí odkaz:
https://doaj.org/article/3debbd027fb049a0a307577c43d0e983
Autor:
Daniel J. Lodge
Publikováno v:
Biological Psychiatry Global Open Science, Vol 1, Iss 2, Pp 83-84 (2021)
Externí odkaz:
https://doaj.org/article/67da06a2442844fc9fc86eb275eefbd6