Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Daniel J Lindner"'
Autor:
Katarzyna Bialkowska, Lamyae El Khalki, Priyanka S. Rana, Wei Wang, Daniel J. Lindner, Yvonne Parker, Lucia R. Languino, Dario C. Altieri, Elzbieta Pluskota, Khalid Sossey-Alaoui, Edward F. Plow
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Kindlin-2 is a cytoskeletal adapter protein that is present in many different cell types. By virtue of its interaction with multiple binding partners, Kindlin-2 intercalates into numerous signaling pathways and cytoskeletal nodes. A specific
Externí odkaz:
https://doaj.org/article/5573cad98044439ab462d68666ca541d
Autor:
Aaron Petty, Eugene Myshkin, Haina Qin, Hong Guo, Hui Miao, Gregory P Tochtrop, Jer-Tsong Hsieh, Phillip Page, Lili Liu, Daniel J Lindner, Chayan Acharya, Alexander D MacKerell, Eckhard Ficker, Jianxing Song, Bingcheng Wang
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42120 (2012)
During tumor progression, EphA2 receptor can gain ligand-independent pro-oncogenic functions due to Akt activation and reduced ephrin-A ligand engagement. The effects can be reversed by ligand stimulation, which triggers the intrinsic tumor suppressi
Externí odkaz:
https://doaj.org/article/d179e54248b847f4955532d762afd815
Autor:
Joseph A Bauer, Joseph A Lupica, Heidi Schmidt, Bei H Morrison, Rebecca M Haney, Rhonda K Masci, Rebecca M Lee, Joseph A Didonato, Daniel J Lindner
Publikováno v:
PLoS ONE, Vol 2, Iss 12, p e1313 (2007)
Nitrosylcobalamin (NO-Cbl) is a chemotherapeutic pro-drug derived from vitamin B12 that preferentially delivers nitric oxide (NO) to tumor cells, based upon increased receptor expression. NO-Cbl induces Apo2L/TRAIL-mediated apoptosis and inhibits sur
Externí odkaz:
https://doaj.org/article/cb9a3846182e4721a2012c84d91d423b
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-8 (2024)
Abstract Background The current generation of radiolabeled PSMA-targeting therapeutic agents is limited by prominent salivary gland binding, which results in dose-limiting xerostomia from radiation exposure. JB-1498 is a urea-based small molecule wit
Externí odkaz:
https://doaj.org/article/a2cf72a7ba264a219fd6e22305160176
Autor:
Sudipta Biswas, Kai Kang, Kwok Peng Ng, Tomas Radivoyevitch, Kurt Schalper, Hua Zhang, Daniel J. Lindner, Anish Thomas, David MacPherson, Brian Gastman, David S. Schrump, Kwok-Kin Wong, Vamsidhar Velcheti, Yogen Saunthararajah
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 113016- (2023)
Summary: Small cell lung cancers (SCLCs) rapidly resist cytotoxic chemotherapy and immune checkpoint inhibitor (ICI) treatments. New, non-cross-resistant therapies are thus needed. SCLC cells are committed into neuroendocrine lineage then maturation
Externí odkaz:
https://doaj.org/article/6e798291ce2a49cb8119368cddc4ce46
Autor:
Hong Qiu, Vladimir Makarov, Jennifer K. Bolzenius, Angela Halstead, Yvonne Parker, Allen Wang, Gopakumar V. Iyer, Hannah Wise, Daniel Kim, Varna Thayaparan, Daniel J. Lindner, Georges-Pascal Haber, Angela H. Ting, Bing Ren, Timothy A. Chan, Vivek Arora, David B. Solit, Byron H. Lee
Publikováno v:
Cancer Research. 83:814-829
Disruption of KDM6A, a histone lysine demethylase, is one of the most common somatic alternations in bladder cancer. Insights into how KDM6A mutations affect the epigenetic landscape to promote carcinogenesis could help reveal potential new treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::932224665dba79258c263921a78af005
https://doi.org/10.1158/0008-5472.can-22-1444
https://doi.org/10.1158/0008-5472.can-22-1444
Autor:
Reizes, Mariam M. AlHilli, Emily E. Rhoades, Danielle Chau, Surabhi Tewari, Adrian Reich, Alex Myers, Daniel J. Lindner, Justin D. Lathia, Renliang Zhang, Belinda Willard, Gail Cresci, Nathan A. Berger, Ofer
Publikováno v:
Nutrients; Volume 15; Issue 12; Pages: 2730
The ketogenic diet (KD) is hypothesized to impact tumor progression by altering tumor metabolism. In this study, we assessed the impact of an unrestricted KD on epithelial ovarian cancer (EOC) tumor growth, gene expression, and metabolite concentrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::6436f80cd1668c236d9f8e9ae9a55f6c
Autor:
Sanjay Gupta, Firouz Daneshgari, Yvonne Parker, Daniel J. Lindner, Chris A. Flask, Gregory T. MacLennan, Christine Z. Oak, Joseph P. Molter, Michelle A. Puchowicz, Edwin J. Vazquez, Pingfu Fu, Sanjeev Shukla, Melissa A. Babcook
Figure S1. HMG-CoAR protein is over-expressed and its degradation dysregulated in omCRPC cell lines. Figure S2. Total cholesterol significantly increased in omCRPC cell lines. Figure S3. Cellular free-to-total cholesterol ratio minimally affected by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010329ed8e26cb4a48e0d4b1279a3c3d
https://doi.org/10.1158/1535-7163.22502677
https://doi.org/10.1158/1535-7163.22502677
Autor:
Sanjay Gupta, Firouz Daneshgari, Yvonne Parker, Daniel J. Lindner, Chris A. Flask, Gregory T. MacLennan, Christine Z. Oak, Joseph P. Molter, Michelle A. Puchowicz, Edwin J. Vazquez, Pingfu Fu, Sanjeev Shukla, Melissa A. Babcook
Docetaxel chemotherapy remains a standard of care for metastatic castration-resistant prostate cancer (CRPC). Docetaxel modestly increases survival, yet results in frequent occurrence of side effects and resistant disease. An alternate chemotherapy w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499e853c27b0ea49356e290d5c9d45f6
https://doi.org/10.1158/1535-7163.c.6537145
https://doi.org/10.1158/1535-7163.c.6537145
Autor:
Byron H. Lee, David B. Solit, Vivek Arora, Timothy A. Chan, Bing Ren, Angela H. Ting, Georges-Pascal Haber, Daniel J. Lindner, Varna Thayaparan, Daniel Kim, Hannah Wise, Gopakumar V. Iyer, Allen Wang, Yvonne Parker, Angela Halstead, Jennifer K. Bolzenius, Vladimir Makarov, Hong Qiu
Supplementary Figure 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d304016580f9014b1a843d9aa4fa9be
https://doi.org/10.1158/0008-5472.22433423
https://doi.org/10.1158/0008-5472.22433423