Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Daniel J Krosky"'
Autor:
Yun Ding, Lisa M. Shewchuk, Martin Brandt, Ami L. Shaw, David I. Israel, Stephen A. Douglas, Gregory D. Brown, Dennis A. Holt, Christine G. Schnackenberg, Rusty E. Fries, Jeffrey W. Gross, Larry J. Jolivette, Tracy Mandichak, Jason W. Dodson, Melissa H. Costell, Mark R. Harpel, Steve H. Eisennagel, Jeff J. McAtee, Theresa J. Roethke, Reema K. Thalji, Svetlana L. Belyanskaya, Hu Li, Wensheng Xie, Joseph P. Marino, Quinn Lu, Benjamin Schwartz, David J. Behm, Daniel J. Krosky
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3584-3588
1-(1,3,5-Triazin-yl)piperidine-4-carboxamide inhibitors of soluble epoxide hydrolase were identified from high through-put screening using encoded library technology. The triazine heterocycle proved to be a critical functional group, essential for hi
Autor:
L. Mario Amzel, James T. Stivers, Mario A. Bianchet, Daniel J. Krosky, Jared B. Parker, Joshua I. Friedman
Publikováno v:
Nature. 449:433-437
The enzyme uracil DNA glycosylase (UNG) excises unwanted uracil bases in the genome using an extrahelical base recognition mechanism. Efficient removal of uracil is essential for prevention of C-to-T transition mutations arising from cytosine deamina
Autor:
Suhman Chung, James T. Stivers, Lauren Seiple, L. Mario Amzel, Mario A. Bianchet, Daniel J. Krosky
Publikováno v:
Nucleic Acids Research
Human nuclear uracil DNA glycosylase (UNG2) is a cellular DNA repair enzyme that is essential for a number of diverse biological phenomena ranging from antibody diversification to B-cell lymphomas and type-1 human immunodeficiency virus infectivity.
Publikováno v:
Nature Structural Biology. 9:659-664
The Escherichia coli enzyme 3-methyladenine DNA glycosylase I (TAG) hydrolyzes the glycosidic bond of 3-methyladenine (3-MeA) in DNA and is found in many bacteria and some higher eukaryotes. TAG shows little primary sequence identity with members of
Autor:
Richard A. Alm, Mikael Berg, Bo Xu, Wei Yang, Peter J. Tummino, Daniel J Krosky, Gilles Carmel
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1594:297-306
3-Deoxy- D - manno -2-octulosonate-8-phosphate (KDO-8-P) synthase catalyzes the aldol-type condensation of phosphoenolpyruvate and D -arabinose-5-phosphate (A-5-P) to produce KDO-8-P and inorganic phosphate. All KDO-8-P synthases, as exemplified by t
Autor:
Mark R. Harpel, Robert N. Willette, Daniel J. Krosky, Jianqi Cui, Christine G. Schnackenberg, Charlene W. Wu, Tian-Li Yue, Melissa H. Costell, Victor S. Hong
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2013 (2013)
BioMed Research International, Vol 2013 (2013)
Metabolic syndrome is a constellation of risk factors including hypertension, dyslipidemia, insulin resistance, and obesity that promote the development of cardiovascular disease. Metabolic syndrome has been associated with changes in the secretion o
Autor:
Da-Yuan Wang, Stacey L. Walsh, Martin J. Scott, Robert S. Ames, Quinn Lu, Daniel J. Krosky, Hu Li, Thomas D. Sweitzer, Sundip Modha, Lisa A. Payne
Publikováno v:
Molecular biotechnology. 39(2)
Cortisol is an important glucocorticoid in humans that regulates many physiological processes. Human 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone to cortisol in vivo and has emerged as an appealing therapeutic target fo
Publikováno v:
Journal of the American Chemical Society. 128(40)
Uracil DNA glycosylase (UNG) locates uracil and its structural congener thymine in the context of duplex DNA using a base flipping mechanism. NMR imino proton exchange measurements were performed on free and UNG-bound DNA duplexes in which a single t