Cell-to-cell variation and specialization in sugar metabolism in clonal bacterial populations.

Autor: Nela Nikolic, Frank Schreiber, Alma Dal Co, Daniel J Kiviet, Tobias Bergmiller, Sten Littmann, Marcel M M Kuypers, Martin Ackermann

Publikováno v: PLoS Genetics, Vol 13, Iss 12, p e1007122 (2017)

While we have good understanding of bacterial metabolism at the population level, we know little about the metabolic behavior of individual cells: do single cells in clonal populations sometimes specialize on different metabolic pathways? Such metabo

Externí odkaz: https://doaj.org/article/e3bf80cf6fab46c7977f843347ab8d04

Wide lag time distributions break a trade-off between reproduction and survival in bacteria

Autor: Stefany Moreno-Gámez, Martin Ackermann, Susan Schlegel, Clément Vulin, Kim Schlegel, G. Sander van Doorn, Daniel J. Kiviet

Publikováno v: Proceedings of the National Academy of Science of the United States of America, 117(31), 18729-18736. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America, 117 (31)
Proc Natl Acad Sci U S A

Many microorganisms face a fundamental trade-off between reproduction and survival: Rapid growth boosts population size but makes microorganisms sensitive to external stressors. Here, we show that starved bacteria encountering new resources can break

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0151bd18ffbb68a602faa17973e8914
https://research.rug.nl/en/publications/c448e49f-a113-4cc1-a9b4-afb83c506c33

Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity

Autor: Enrique Balleza, Anna Mc Andersson, Robert Hauschild, Călin C. Guet, Gašper Tkačik, Daniel J. Kiviet, Tobias Bergmiller, Kathrin Tomasek

Publikováno v: Science

Drug efflux machinery inherited asymmetrically In dividing bacterial cells, asymmetric distribution of cell wall constituents occurs between mother cells and their progeny. Asymmetric distribution of efflux machinery in a growing population of bacter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20cd5bf175b0657d7c76aa6cb5b1453
https://doi.org/10.1126/science.aaf4762

Short-range interactions govern cellular dynamics in microbial multi-genotype systems

Autor: Martin Ackermann, Susan Schlegel, S. van Vliet, A. Dal Co, Daniel J. Kiviet

Ecosystem processes result from interaction between organisms. When interactions are local, the spatial organization of organisms defines their network of interactions, and thus influences the system’s functioning. This can be especially relevant f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ecfc2247928057c0350001df800c3a

Effective polyploidy causes phenotypic delay and influences bacterial evolvability

Autor: Martin Ackermann, Balázs Bogos, Daniel J. Kiviet, Lei Sun, Helen K. Alexander, Sebastian Bonhoeffer

Publikováno v: PLoS Biology, 16 (2)
Sun, L, Alexander, H K, Bogos, B, Kiviet, D J, Ackermann, M & Bonhoeffer, S 2018, ' Effective polyploidy causes phenotypic delay and influences bacterial evolvability ', PLoS Biology, vol. 16, no. 2, e2004644 . https://doi.org/10.1371/journal.pbio.2004644
PLoS Biology
PLoS Biology, Vol 16, Iss 2, p e2004644 (2018)

Whether mutations in bacteria exhibit a noticeable delay before expressing their corresponding mutant phenotype was discussed intensively in the 1940s to 1950s, but the discussion eventually waned for lack of supportive evidence and perceived incompa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0dbc2fdb475aa501434a670b957912a
https://doi.org/10.1101/226654